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An inherited mild middle-aged adiposity in wild mice

Published online by Cambridge University Press:  15 May 2009

Margaret E. Wallace  and
Felicity M. Macswiney
Margaret E. Wallace
Affiliation:
Department of Genetics, University of Cambridge
Felicity M. Macswiney
Affiliation:
Department of Genetics, University of Cambridge
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Summary

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In a warfarin-resistant population of wild mice reared in the laboratory, a dominant gene for adiposity, Ad, was found to segregate. The onset of obesity is at 4–6 months, and adipose mice suffer from hyperinsulinaemia; the sexes differ in penetrance, males having greater penetrance then females. Linkage backcrosses show the gene to be situated on chromosome 7 with about 25% recombination with the closely linked warfarin-resistance genes War, and frizzy, fr. The finding of adipose in two other wild populations also carrying War is discussed as an ecological and physiological problem.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 2 , April 1979 , pp. 309 - 317
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Bailey, N. T. J. (1961). Introduction to the Mathematical Theory of Genetic Linkage. Oxford: Clarendon Press.Google Scholar
Coleman, D. L. (1973). Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294–8.CrossRefGoogle ScholarPubMed
Coleman, D. L. & Hummel, K. P. (1973). The influence of genetic background on the expression of the obese (ob) gene in the mouse. Diabetologia 9, 287–93.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1973). Allelism of adipose (ad) and diabetes (db). Mouse News Letter 48, 27.Google Scholar
James, W. P. T. & Trayhurn, P. (1976). An integrated view of the metabolic and genetic basis for obesity. Lancet ii, 770–73.CrossRefGoogle Scholar
MacSwiney, F. J. & Wallace, M. E. (1978). Genetics of warfarin-resistance in house mice of three separate localities. Journal of Hygiene 80, 69–75.CrossRefGoogle ScholarPubMed
Trayhurn, P., Hawkins, R. A., James, W. P. T., Gurr, M., MacSwiney, F. J. & Wallace, M. E (1978). Ad – a new obese mutant. International Journal of Obesity 2, 75.Google Scholar
Trayhurn, P., James, W. P. T. & Gurr, M. I. (1979). Studies on the body composition, fat distribution and fat cell size and number, of Ad, a new obese mutant mouse. British Journal of Nutrition 41 (in the press).CrossRefGoogle Scholar
Wallace, M. E. & MacSwiney, F. J. (1975). Warfarin resistance and a new gene for obesity. Mouse News Letter 53, 20.Google Scholar
Wallace, M. E. & MacSwiney, F. J. (1976). A major gene controlling warfarin-resistance in the house mouse. Journal of Hygiene 76, 173–81.CrossRefGoogle Scholar