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An in vitro comparison of the effect of some antibacterial, antifungal and antiprotozoal agents on various strains of Mycoplasma (pleuropneumonia–like organisms: P.P.L.O.)

Published online by Cambridge University Press:  15 May 2009

Audrey G. Newnham  and
H. P. Chu
Audrey G. Newnham
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Madingley Road, Cambridge
H. P. Chu
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Madingley Road, Cambridge
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A study was made in liquid medium over 7 days at 37° C. of the inhibitory action of nineteen antibacterial, antifungal and antiprotozoal drugs on twenty strains of M. gallisepticum, eight other avian mycoplasmata, six mammalian mycoplasmata, two saprophytic mycoplasmata and the L-form of Streptobacillus moniliformis (L–1).

The twenty strains of M. gallisepticum from Britain and other countries showed a similar range of drug sensitivity except where resistant strains were included. Tylosin and demethylchlortetracycline appeared to have the highest inhibitory action, followed by erythromycin, spiramycin, tetracycline, chlortetracycline, oxytetracycline and ethidium bromide. A ‘Zone Phenomenon’ frequently occurred with sodium aurothiomalate, inhibition often being observed between 0·1 and 2·0 μg./ml. Polymixin and nystatin had no inhibitory effect on the growth of any mycoplasmata tested. With the exception of erythromycin and streptomycin in some cases, the pattern of sensitivity observed with the mycoplasmata of diverse origin was similar to that of M. gallisepticum, most strains, however, being somewhat more resistant than M. gallisepticum to many of the drugs.

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 1 , March 1965 , pp. 1 - 23
Copyright
Copyright © Cambridge University Press 1965

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