Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-29T08:56:10.764Z Has data issue: false hasContentIssue false
  • English
  • Français

An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs

Published online by Cambridge University Press:  15 May 2009

L. L. Shu ,
N. N. Zhou ,
G. B. Sharp ,
S. Q. He ,
T. J. Zhang ,
W. W. Zou  and
R. G. Webster
L. L. Shu
Affiliation:
Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA
N. N. Zhou
Affiliation:
Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China
G. B. Sharp
Affiliation:
Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA Department of Hematology/ Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA
S. Q. He
Affiliation:
Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China
T. J. Zhang
Affiliation:
Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China
W. W. Zou
Affiliation:
Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China
R. G. Webster*
Affiliation:
Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA
*
* Corresponding author.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.

Type
Research Article
Information
Epidemiology & Infection , Volume 117 , Issue 1 , August 1996 , pp. 179 - 188
Copyright
Copyright © Cambridge University Press 1996

References

1.Lamb, RA. The influenza virus RNA segments and their encoded proteins. In: Palese, P, Kingsbury, DW, ed. Genetics of influenza viruses. New York: Springer-Verlag, 1983: 21–69.Google Scholar
2.Hinshaw, VS, Webster, RG. The natural history of influenza A viruses. In: Beare, AS, ed. Basic and applied influenza research. Boca Raton, FL: CRC press, 1982: 79–104.Google Scholar
3.Webster, RG, Guo, YJ. New influenza virus in horses. Nature 1991; 351: 527.CrossRefGoogle ScholarPubMed
4.Kundin, WD. Hong Kong A-2 influenza virus infection among swine during a human epidemic in Taiwan. Nature 1970; 228: 857.CrossRefGoogle ScholarPubMed
5.Hinshaw, VS, Bean, WJ, Geraci, J, Fiorelli, P, Early, G, Webster, RG. Characterization of two influenza A viruses from a pilot whale. J Virol 1986;58: 655–6.CrossRefGoogle ScholarPubMed
6.Webster, RG, Laver, WG. The origin of pandemic influenza. Bull WHO 1972; 47: 449–52.Google ScholarPubMed
7.Scholtissek, C, Rohde, W, Von Hoyningen, V, Rott, R. On the origin of the human influenza virus subtypes H2N2 and H3N2. Virol 1978; 87: 13–20.CrossRefGoogle ScholarPubMed
8.Kawaoka, Y, Krauss, S, Webster, RG. Avian-to-human transmission of the PBI gene of influenza A viruses in the 1957 and 1968 pandemic. J Virol 1989; 63: 4603–8.CrossRefGoogle Scholar
9.Webster, RG, Bean, WJ, Gorman, OT, Chambers, TM, Kawaoka, Y. Evolution and ecology of influenza A viruses. Microbiol Rev 1992; 56: 152–79.CrossRefGoogle ScholarPubMed
10.Castrucci, MR, Donatelli, I, Sidoli, L, Giuseppe, B, Kawaoka, Y, Webster, RG. Genetic reassortment between avian and human influenza A virus in Italian pigs. Virol 1993 193: 503–6.CrossRefGoogle ScholarPubMed
11.Hinshaw, VS, Bean, WJ, Webster, RG. The prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine. Virol 1978; 84: 51–62.CrossRefGoogle ScholarPubMed
12.Rota, PA, Rocha, EP, Harmon, MW. Laboratory characterization of a swine influenza virus isolated from a fatal case of human influenza. J Clin Microbiol 1989; 27: 1413–6.CrossRefGoogle ScholarPubMed
13.Wells, DL, Hopfensperger, DJ, Arden, NH. Swine influenza virus infections: Transmission from ill pigs to humans at a Wisconsin Agricultural Fair and subsequent probable person-to-person transmission. J AMA 1991; 265: 478–81.Google Scholar
14.Shortridge, KF, Stuart-Harris, CH. An influenza epicenter? Lancet 1982; 9: 812–13.CrossRefGoogle Scholar
15.Kendal, AP, Pereira, MS, Skehel, JJ. Concepts and procedures for laboratory-based influenza surveillance. U.S. Public Health Service, 1982.Google Scholar
16.Wright, SM, Kawaoka, Y, Sharp, GB, Senne, DA, Webster, RG. Interspecies transmission and reassortment of influenza A viruses in pigs and turkeys in the United States. Am J Epidemiol 1992; 136: 488–97.CrossRefGoogle ScholarPubMed
17.Krisnan, BR, Blakesley, RW, Berg, DE. Linear amplification DNA sequencing from single phage plaques and bacterial colonies. Nucl Acids Res 1991; 19: 1153.CrossRefGoogle Scholar
18.Gorman, OT, Bean, WJ, Webster, RG. Evolutionary processes in influenza viruses: Divergene, rapid evolution, and stasis. Curr Top Microbiol Immunol 1992; 176: 75–97.Google Scholar
19.Shu, LL, Lin, YP, Wright, SM, Shortridge, KF, Webster, RG. Evidence for interspecies transmission and reassortment of influenza A viruses in pigs in Southern China. Virol 1994; 202: 825–33.CrossRefGoogle ScholarPubMed
20.Reichelderfer, PS, Kendal, AP, Shortridge, KF, Hampson, A, and collaborators. Influenza surveillance in the Pacific Basin. Seasonality of virus occurrence: A preliminary report. In: Chan, YC, Doraisingham, S, Ling, AE, eds., Curr topics in med virol, First Asia-PacificCongress of Medical Virology, 1988: 412–37.Google Scholar
21.Fox, JP, Cooney, MK, Hall, CE, Foy, HM. Rhinovirus infections in Seattle families, 1975–1979. Am J Epidemiol 1985; 122: 830–46.CrossRefGoogle ScholarPubMed
22.Parkinson, AJ, Muchmore, HG, Scott, LV, Kalmakoff, J, Miles, JA. Parainfluenza virus upper respiratory tract illnesses in partially immune adult human subjects: a study at an Antarctic station. Am J Epidemiol 1979; 110: 753–63.CrossRefGoogle ScholarPubMed
23.Shortridge, KF. Pandemic influenza: a zoonosis? Semin Respir Infect 1992; 7: 11–25.Google ScholarPubMed
24.Beare, AS, Webster, RG. Replication of avian influenza viruses in humans. Arch Virol 1991; 119: 37–42.CrossRefGoogle ScholarPubMed
25.Guo, YJ, Wang, M, Kawaoka, Y, et al. Characterization of a new avian-like influenza A virus from horses in China. Virology 1992; 188: 245–55.CrossRefGoogle ScholarPubMed
26.Webster, RG, Geraci, JR, Petursson, G, Skirnisson, K. Conjunctivitis in human beings caused by influenza A virus of seals. N Engl J Med 1981; 304: 911.Google ScholarPubMed
27.Hinshaw, VS, Bean, WJ, Webster, RG, et al. Are seals frequently infected with avian influenza viruses? J Virol 1984; 51: 863–5.CrossRefGoogle ScholarPubMed
28.Lvov, DK, Zhdanov, VM, Sazonov, AA, et al. Comparison of influenza viruses isolated from man and from whales. Bull WHO 1978; 56: 923–30.Google ScholarPubMed
29.Lin, YP, Shu, LL, Wright, SM, et al. Analysis of the influenza virus gene pool in avian species from Southern China. Virol 1994; 198: 557–66.CrossRefGoogle ScholarPubMed
30.Gorman, OT, Bean, WJ, Kawaoka, Y, Donatelli, I, Guo, Y, Webster, RG. Evolution of influenza A virus nucleoprotein genes: Implications for the origins of H1N1 human and classical swine viruses. J Virol 1991; 65: 3704–14.CrossRefGoogle ScholarPubMed