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An assessment of methods for routine local monitoring of vaccine efficacy, with particular reference to measles and pertussis

Published online by Cambridge University Press:  19 October 2009

J. A. Clarkson  and
P. E. M. Fine
J. A. Clarkson
Affiliation:
Ross Insitute, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
P. E. M. Fine
Affiliation:
Ross Insitute, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
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Summary

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The efficacy of measles and pertussis vaccines was investigated using several different procedures based upon data routinely available at Local Health Authority level in England and Wales. It is demonstrated that such estimates can be derived by methods which can be carried out simply and routinely by local health department staff. Several theoretical and practical difficulties in the procedures are discussed. It is recommended that Health Authorities consider monitoring by a routine procedure based on crude case-control analysis of recorded vaccination status of notified cases compared with that of the population in the Child Health computer file, or of matched controls drawn from Child Health Registers. A simple protocol for such studies is provided.

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 2 , October 1987 , pp. 485 - 499
Copyright
Copyright © Cambridge University Press 1987

References

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