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Amino-acid change on the antigenic region B1 of H3 haemagglutinin may be a trigger for the emergence of drift strain of influenza A virus

Published online by Cambridge University Press:  12 May 2004

K. SATO ,
T. MORISHITA ,
E. NOBUSAWA ,
K. TONEGAWA ,
K. SAKAE ,
S. NAKAJIMA  and
K. NAKAJIMA
K. SATO
Affiliation:
Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya 462-8576, Japan
T. MORISHITA
Affiliation:
Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya 462-8576, Japan
E. NOBUSAWA
Affiliation:
Department of Virology, Medical School, Nagoya City University, Nagoya 467-8601, Japan
K. TONEGAWA
Affiliation:
Department of Virology, Medical School, Nagoya City University, Nagoya 467-8601, Japan
K. SAKAE
Affiliation:
Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya 462-8576, Japan
S. NAKAJIMA
Affiliation:
Department of Virology, Medical School, Nagoya City University, Nagoya 467-8601, Japan
K. NAKAJIMA
Affiliation:
Department of Virology, Medical School, Nagoya City University, Nagoya 467-8601, Japan
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Abstract

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Sera from 27 children and eight older persons, which had been collected in 1998 and 1999 and showed haemagglutination–inhibition (HI) activity against influenza A/Sydney/5/97 (H3N2) strain, were characterized with a binding assay using chimeric haemagglutinin (HA) proteins between A/Aichi/2/68 (A/AI/68) and A/Sydney/5/97 (A/SD/97) strains. Sera from the young children had a tendency to recognize only the antigenic site B1 of the HA1 region. On the other hand, sera of the older individuals were fully reactive to all antigenic sites of HA1 except antigenic site D. Recent epidemic strains, A/Panama/2007/99 (A/PM/99)-like viruses have differences in amino acids in antigenic sites A, C, and B2 but not B1. However, human antisera obtained even from young children had HI activity to Panama-like viruses. The limited epidemic of A/PM/99-like viruses may have been due to the existence of antibody against B1, which had been produced in response to infection by the A/SD/97-like viruses.

Type
Research Article
Information
Epidemiology & Infection , Volume 132 , Issue 3 , June 2004 , pp. 399 - 406
Copyright
© 2004 Cambridge University Press