Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-22T15:37:20.704Z Has data issue: false hasContentIssue false
  • English
  • Français

Allergy in experimental rat tuberculosis

Published online by Cambridge University Press:  15 May 2009

David F. Gray ,
John L. Noble  and
Mary O'Hara
David F. Gray
Affiliation:
From the school of Microbiology, University of Melbourne, Parkville, N. 2, Victoria, Australia
John L. Noble
Affiliation:
From the school of Microbiology, University of Melbourne, Parkville, N. 2, Victoria, Australia
Mary O'Hara
Affiliation:
From the school of Microbiology, University of Melbourne, Parkville, N. 2, Victoria, Australia
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. This paper confirms and extends several observations during the past 20 years that, despite many reports to the contrary, the rat is not unduly resistant to initial infection with tubercle bacilli provided they lodge in the lungs.

2. The pattern of pathogenesis in the rat is probably closest to the now classical picture in the mouse, i.e. the response of a species with a low hypersensitivity potential. The pathology of the lesions agreed closely with the descriptions of Wessels (1941) and Kumashiro (1958b) resembling the mouse in most respects but, unlike the mouse, including the production of giant cells.

3. When tested by footpad inoculation with 1/3·5 Old Tuberculin a positive reaction was demonstrated, commencing between 2 and 5 weeks after infection and persisting for several weeks. A fatal systemic reaction could often be induced with large doses of tuberculin given intraperitoneally.

4. In a few cases loss of allergy was shown to be associated with a terminal anergic flare of the type observed previously in mice and guinea-pigs.

Type
Research Article
Information
Journal of Hygiene , Volume 59 , Issue 4 , December 1961 , pp. 427 - 436
Copyright
Copyright © Cambridge University Press 1961

References

Dougherty, T. F. (1952). Allergy in mice. Recent Progr. Hormone Res. 7, 307.Google Scholar
Gloyne, S. R. & Page, D. S. (1923). Reaction to B. tuberculosis in the albino rat. J. Path. Bact. 26, 224.CrossRefGoogle Scholar
Gray, D. F. (1958). Immunity, natural anergy and artificial desentization in experimental tuberculosis. Amer. Rev. Tuberc. 78, 235.Google Scholar
Gray, D. F. (1959). Fate of tubercle bacilli in early experimental infection of the mouse. J. Hyg. Camb., 57, 473Google ScholarPubMed
Gray, D. F. (1961). The relative natural resistance of rats and mice to experimental pulmonary tuberculosis. J. Hyg. Camb., 59, 471.Google ScholarPubMed
Gray, D. F. & Affleck, M. N. (1958). Relationship of allergy to gross lung disease and culturable bacilli in tuberculous mice. Amer. Rev. Tuberc. 78, 226.Google ScholarPubMed
Gray, D. F., Graham-Smith, H. & Noble, J. L. (1960). Variations in natural resistance to tuberculosis. J. Hyg., Camb., 58, 215.CrossRefGoogle ScholarPubMed
Gray, D. F. & Jennings, P. A. (1955). Allergy in experimental mouse tuberculosis. Amer. Rev. Tuberc. 72, 171.Google ScholarPubMed
Gray, D. F. & Mattinson, M. W. (1952). Detection of small numbers of tubercle bacilli from dispersed cultures. Amer. Rev. Tuberc. 65, 572.Google ScholarPubMed
Hehre, E. & Freund, J. (1939). Sensitization, antibody formation and lesions produced by tubercle bacilli in the albino rat. Arch. Path. (Lab. Med.) 27, 289.Google Scholar
Kumashiro, A. (1958 a). Growth of mycobacteria in rats and gross organ changes. Acta tuberc. Japon. 8, 1.Google ScholarPubMed
Kumashiro, A. (1958 b). Histological examination of rats infected with various strains of mycobacteria. Acta tuberc. Japon. 8, 10.Google ScholarPubMed
Ornstein, G. G. & Steinbach, M. M. (1925). The resistance of the albino rat to infection with tubercle bacilli. Amer. Rev. Tuberc. 12, 77.Google Scholar
Perla, D. (1936). Protective action of copper against infection with Mycobacterium tuberculosis (bovine) in albino rats. Proc. Soc. exp. Biol., N.Y. 34, 365.CrossRefGoogle Scholar
Ratcliffe, H. L. & Palladino, V. S. (1953). Tuberculosis induced by droplet nuclei infection. J. exp. Med. 97, 61.CrossRefGoogle ScholarPubMed
Rich, A. R. (1951). The Pathogenesis of Tuberculosis, p. 306, 2nd ed.Oxford: Blackwell.Google Scholar
Smith, M. I. (1925–1926). Experimental tuberculosis in albino rats and the influence of vitamin deficient diets thereon. J. Lab. clin. Med. 11, 712.Google Scholar
Trethewie, E. R. (1947). Histamine and phosgene poisoning. Med. J. Aust. (21 June), p. 746.CrossRefGoogle ScholarPubMed
Wessels, C. C. (1941). Tuberculosis in the rat. Amer. Rev. Tuberc. 43, 449.Google Scholar