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Age-dependent prevalence of BK virus IgG and IgM antibodies measured by enzyme-linked immunosorbent assays (ELISA)

Published online by Cambridge University Press:  19 October 2009

Trond Flaegstad ,
Terje Traavik  and
Bjørn-Erik Kristiansen
Trond Flaegstad
Affiliation:
Departments of Microbiology, (Institute of Medical Biology), and Paediatrics (Institute of Clinical Medicine)
Terje Traavik
Affiliation:
Department of Microbiology, (Institute of Medical Biology) University of Tromsø, N–9012 Tromsø, Norway
Bjørn-Erik Kristiansen
Affiliation:
Department of Microbiology, (Institute of Medical Biology) University of Tromsø, N–9012 Tromsø, Norway
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Summary

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Enzyme immunoassays (ELISA) have been developed for the detection of BK virus IgG- and IgM-antibodies. Specific IgG is detected by an antigen-coated solid phase test; IgM by an antibody capture method.

These methods have been used to study the age-distribution of BK virus antibodies in Troms county in Northern Norway. The serum panels tested were: (a) 60 sera from paediatric patients aged 0–1 year; (b) 220 sera from healthy persons aged 1–82 years; (c) 74 sera from healthy blood donors; (d) 107 sera from healthy pregnant women.

The age-distribution of BKV-IgG antibodies showed that primary infections took place predominantly between the ages of 1 and 6 years, and that there were no sex differences, either in the age-specific prevalence or in the level of BKV-IgG.

We found no significant differences in the prevalence of BKV-IgM antibodies in healthy children and adults and pregnant women. BKV-IgM was detected in 26 of the 461 sera tested (5·6%).

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 3 , June 1986 , pp. 523 - 528
Copyright
Copyright © Cambridge University Press 1986

References

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