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The adverse effect of dilution on the infectivity of Fusobacterium necrophorum culture

Published online by Cambridge University Press:  19 October 2009

G. R. Smith  and
Ann Turner
G. R. Smith
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY, UK
Ann Turner
Affiliation:
Nuffield Laboratories of Comparative Medicine, Institute of Zoology, The Zoological Society of London, Regent's Park, London NW1 4RY, UK
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Summary

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Dilution had an adverse effect on the infectivity of 24 h cultures of a strain of Fusobacterium necrophorum, which became apparent at or near the minimum lethal dose. Thus in mice inoculated subcutaneously the mortality produced by 0·01 ml of undiluted culture was almost invariably greater than that produced by 0·1 ml of a 1 in 10 dilution. The explanation appeared to lie in the increased physical separation of bacterial cells that was the inevitable consequence of dilution.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 2 , April 1986 , pp. 199 - 203
Copyright
Copyright © Cambridge University Press 1986

References

REFERENCES

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