The genus Campylanthus (Scrophulariaceae) is revised and 15 species are recognized. The genus shows a markedly disjunct pattern of distribution, with two species in Macaronesia, 12 in northeastern Africa and Arabia, and one in western Pakistan. With few exceptions all have very restricted distributions. The position of the genus within the Scrophulariaceae is discussed, and it is concluded that Campylanthus is best placed as incertae sedis. Morphological aspects of the genus are discussed and a cladistic analysis including all species is presented. The analysis indicates a basal split between western and eastern species in the genus. A key, descriptions and distribution maps for all species are provided, and some lectotypes and neotypes are selected.