The problem addressed in this paper is to test the null hypothesis that a time series process is uncorrelated up to lag K in the presence of statistical dependence. We propose an extension of the Box–Pierce Q-test that is asymptotically distributed as chi-square when the null is true for a very general class of dependent processes that includes non-martingale difference sequences. The test is based on a consistent estimator of the asymptotic covariance matrix of the sample autocorrelations under the null. The finite sample performance of this extension is investigated in a Monte Carlo study.