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Profiles of Human Enteroviruses Associated with Hand, Foot, and Mouth Disease in Nanjing, China

Published online by Cambridge University Press:  01 February 2019

Qian Chen ,
Qihua Zhang  and
Zheng Hu
Qian Chen
Affiliation:
Institute of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Qihua Zhang
Affiliation:
Institute of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Zheng Hu*
Affiliation:
Institute of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
*
Correspondence and reprint requests to Zheng Hu, Institute of Pediatrics, Children’s Hospital of Nanjing Medical University, No.72 Guangzhou Road, Nanjing, Jiangsu 210008, China (e-mail: [email protected]).
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Abstract

Objective

Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by a group of viruses. The causative viruses have changed over time, and there is a need for a more effective protective vaccine. In this study, we investigated the profiles of human enteroviruses that caused HFMD outbreaks in Nanjing in 2015, with the goal of guiding the future prevention and treatment of HFMD.

Methods

Specimens were collected from 1097 patients admitted to our hospital and diagnosed with HFMD. Enteroviruses in the specimens were identified by real-time polymerase chain reaction and epidemiological patterns were analyzed with the clinical data.

Results

Among the 1097 clinically diagnosed HFMD cases, 916 cases were confirmed by laboratory tests. The results showed that the main infectious virus was coxsackievirus A6 (CVA6) (41.75%), followed by enterovirus 71 (EV71) (27.48%), coxsackievirus A16 (7.43%), coxsackievirus A10 (6.84%), and others (16.51%). Further investigation indicated that CVA6 caused mild cases of HFMD, while EV71 caused severe cases. More enterovirus positive cases were reported from rural areas than from urban areas.

Conclusions

CA6 and EV71 were the chief pathogenic viruses of HFMD cases in the present study. Schools, childcare centers, and families from rural areas should be the major targets for prevention and awareness of HFMD. This study will provide information useful in the prevention and management of HFMD and the development of relevant vaccines for HFMD in the future. (Disaster Med Public Health Preparedness. 2019;13:740–744).

Keywords

hand, foot, and mouth diseasecoxsackievirus A6enterovirus 71epidemiological monitoring
Type
Original Research
Information
Disaster Medicine and Public Health Preparedness , Volume 13 , Issue 4 , August 2019 , pp. 740 - 744
Copyright
Copyright © 2019 Society for Disaster Medicine and Public Health, Inc. 

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