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Effect of Inactivated Vaccines Against SARS-CoV-2 on Immunogenicity Outcome

Published online by Cambridge University Press:  04 March 2025

Yuke Ma ,
Yukuan Du ,
Jingnan Yang ,
Huichao Wang  and
Xuhong Lin
Yuke Ma
Affiliation:
School of Clinical Medicine, Henan University, Kaifeng, China
Yukuan Du
Affiliation:
Department of Clinical Laboratory, Huaihe Hospital of Henan University, Kaifeng, China
Jingnan Yang
Affiliation:
Department of Clinical Laboratory, Huaihe Hospital of Henan University, Kaifeng, China
Huichao Wang
Affiliation:
Department of Nephrology, The First Affiliated Hospital of Henan University, Kaifeng, China
Xuhong Lin*
Affiliation:
Department of Clinical Laboratory, Huaihe Hospital of Henan University, Kaifeng, China
*
Corresponding author: Xuhong Lin; Email: [email protected]
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Abstract

Objectives

The purpose of this study was to measure and examine the levels of IgG, IgM, and Spike antibody induced by inactivated vaccines, including CoronaVac and BBIBP-CorV.

Methods

Two groups of healthy adults over 18 years old (50 participants per group), who had previously received 1 dose of either BBIBP-CorV or CoronaVac and receiving either a homologous booster of BBIBP-CorV or a heterologous booster of CoronaVac. Serum IgG, IgM, and Spike antibody levels against SARS-COV-2 were measured using magnetic particle chemiluminescence immunoassay and the ELISA method.

Results

The results showed that both spike antibody and IgG/IgM antibodies elicited by a CoronaVac booster following 1 dose of BBIBP-CorV were significantly higher than those elicited by either a homologous BBIBP-CorV booster or a heterologous BBIBP-CorV booster. The Spike antibody against SARS-COV-2 induced by the heterologous CoronaVac booster reached 200.3, which is substantially greater than that induced by the homologous BBIBP-CorV booster (127.5 pg/mL). Conversely, the Spike antibody against SARS-COV-2 induced by the heterologous BBIBP-CorV booster reached 53.93 pg/mL, which is substantially greater than that induced by the homologous CoronaVac booster (9.60 pg/mL).

Conclusions

In summary, CoronaVac is immunogenic as a booster dose following 1 dose of BBIBP-CorV and is immunogenically superior to both the homologous booster and the heterologous BBIBP-CorV booster.

Keywords

COVID-19SARS-COV-2IgG antibodyvaccinationSpike protein
Type
Original Research
Information
Disaster Medicine and Public Health Preparedness , Volume 19 , 2025 , e50
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Society for Disaster Medicine and Public Health, Inc

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References

Deng, S-Q, Peng, H-J. Characteristics of and public health responses to the Coronavirus Disease 2019 outbreak in China. J Clin Med. 2020;9(2):575. doi: 10.3390/jcm9020575CrossRefGoogle Scholar
Huang, C, Wang, Y, Li, X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497–506. doi: 10.1016/s0140-6736(20)30183-5CrossRefGoogle ScholarPubMed
WHO. (2020). WHO Coronavirus (COVID-19) Dashboard[J/OL]. Published December 2020. Accessed April 22, 2022. https://covid19.who.int/.Google Scholar
Rio, CD, Malani, PN, Omer, SB. Confronting the Delta Variant of SARS-CoV-2, Summer 2021. JAMA. 2021;326(11):1001–1002. doi: 10.1001/jama.2021.14811Google ScholarPubMed
Mallapaty, S. China’s COVID vaccines have been crucial - now immunity is waning. Nature. 2021;598(7881):398–399. doi: 10.1038/d41586-021-02796-wCrossRefGoogle ScholarPubMed
Gao, Q, Bao, L, Mao, H, et al. Development of an inactivated vaccine candidate for SARS-CoV-2. Science (New York, N.Y.). 2020;369(6499):77–81. doi: 10.1126/science.abc1932CrossRefGoogle ScholarPubMed
Wu, Z, Hu, Y, Xu, M, et al. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. Lancet. 2021;21(6):803–812. doi: 10.1016/s1473-3099(20)30987-7CrossRefGoogle Scholar
Wang, H, Zhang, Y, Huang, B, et al. Development of an inactivated vaccine candidate, BBIBP-CorV, with potent protection against SARS-CoV-2. Cell. 2020;182(3):713–721.e719. doi: 10.1016/j.cell.2020.06.008CrossRefGoogle ScholarPubMed
Noda, K, Matsuda, K, Yagishita, S, et al. A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies. Sci Rep. 2021;11(1):5198. doi: 10.1038/s41598-021-84387-3CrossRefGoogle ScholarPubMed
Al Kaabi, N, Zhang, Y, Xia, S, et al. Effect of 2 inactivated SARS-CoV-2 vaccines on symptomatic COVID-19 infection in adults: a randomized clinical trial. JAMA. 2021;326(1):35–45. doi: 10.1001/jama.2021.8565CrossRefGoogle ScholarPubMed
Ismail AlHosani, F, Eduardo Stanciole, A, Aden, B, et al. Impact of the Sinopharm’s BBIBP-CorV vaccine in preventing hospital admissions and death in infected vaccinees: results from a retrospective study in the emirate of Abu Dhabi, United Arab Emirates (UAE). Vaccine. 2022;40(13):2003–2010. doi: 10.1016/j.vaccine.2022.02.039CrossRefGoogle ScholarPubMed
Jeewandara, C, Aberathna, IS, Pushpakumara, PD, et al. Persistence of immune responses to the Sinopharm/BBIBP-CorV vaccine. Immun Inflamm Dis. 2022;10(6):e621.CrossRefGoogle Scholar
Palacios, R, Patiño, EG, de Oliveira Piorelli, R, et al. Double-blind, randomized, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of treating healthcare professionals with the adsorbed COVID-19 (inactivated) vaccine manufactured by Sinovac - PROFISCOV: a structured summary of a study protocol for a randomised controlled trial. Trials. 2020;21(1):853. doi: 10.1186/s13063-020-04775-4CrossRefGoogle ScholarPubMed
Chen, Y, Shen, H, Huang, R, et al. Serum neutralising activity against SARS-CoV-2 variants elicited by CoronaVac. Lancet Infect Dis. 2021;21(8):1071–1072. doi: 10.1016/s1473-3099(21)00287-5CrossRefGoogle ScholarPubMed
Wang, GL, Wang, ZY, Duan, LJ, et al. Susceptibility of circulating SARS-CoV-2 variants to neutralization. N Engl J Med. 2021;384(24):2354–2356. doi: 10.1056/NEJMc2103022CrossRefGoogle ScholarPubMed
Souza, WM, Amorim, MR, Sesti-Costa, R, et al. Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: an immunological study. Lancet. 2021;2(10):e527–e535. doi: 10.1016/s2666-5247(21)00129-4Google ScholarPubMed
Li, X-N, Huang, Y, Wang, W, et al. Effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: a test-negative case-control real-world study. Emerg Microbes Infect. 2021;10(1):1751–1759. doi: 10.1080/22221751.2021.1969291CrossRefGoogle ScholarPubMed
Bar-On, YM, Goldberg, Y, Mandel, M, et al. Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel. N Engl J Med. 2021;385(15):1393–1400. doi: 10.1056/NEJMoa2114255CrossRefGoogle ScholarPubMed
AlKaabi, N, Yang, YK, Zhang, J, et al. Safety and immunogenicity of a heterologous boost with a recombinant vaccine, NVSI-06-07, in the inactivated vaccine recipients from UAE: a phase 2 randomised, double-blinded, controlled clinical trial. MedRxiv. 2022; doi: 10.1101/2021.12.29.21268499CrossRefGoogle Scholar
Wanlapakorn, N, Suntronwong, N, Phowatthanasathian, H, et al. Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study. Hum Vaccin Immunother. 2022;18(1). doi: 10.1080/21645515.2022.2029111CrossRefGoogle ScholarPubMed
Zhang, J, He, Q, An C, et al. Boosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine. Emerg Microbes Infect. 2021;10(1):1598–1608. doi: 10.1080/22221751.2021.1957401CrossRefGoogle ScholarPubMed
Chansaenroj, J, Suntronwong, N, Kanokudom, S, et al. Immunogenicity following two doses of the BBIBP-CorV vaccine and a third booster dose with a viral vector and mRNA COVID-19 vaccines against Delta and Omicron variants in prime immunized adults with two doses of the BBIBP-CorV vaccine. Vaccines. 2022;10(7):1071. doi: 10.3390/vaccines10071071CrossRefGoogle Scholar
Chemaitelly, H, Tang, P, Hasan, MR, et al. Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar. N Engl J Med. 2021;385(24).e83. doi: 10.1056/NEJMoa2114114CrossRefGoogle ScholarPubMed
Zeng, G, Wu, Q, Pan, H, et al. Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials. Lancet. 2022;22(4):483–495. doi: 10.1016/S1473-3099(21)00681-2CrossRefGoogle ScholarPubMed
Pilishvili, T, Gierke, R, Fleming-Dutra, KE, et al. Effectiveness of mRNA Covid-19 vaccine among U.S. health care personnel. New Engl J Med. 2021;385(25):e90. doi: 10.1056/NEJMoa2106599CrossRefGoogle ScholarPubMed
Kunal, S, Sakthivel, P, Gupta, N, et al. Mix and match COVID-19 vaccines: potential benefit and perspective from India. Postgrad Med J. 2022;98(e2):e99–e101. doi: 10.1136/postgradmedj-2021-140648CrossRefGoogle ScholarPubMed
Du, S, Cao, Y, Zhu, Q, et al. Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell. 2020;183(4):1013–1023 e1013. doi: 10.1016/j.cell.2020.09.035CrossRefGoogle ScholarPubMed
Legros, V, Denolly, S, Vogrig, M, et al. A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity. Cell Mol Immunol. 2021;18(2):318–327. doi: 10.1038/s41423-020-00588-2CrossRefGoogle ScholarPubMed
Israel, A, Shenhar, Y, Green, I, et al. Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection. Vaccines (Basel). 2021;10(1):64. doi: 10.3390/vaccines10010064CrossRefGoogle ScholarPubMed
Wheatley, AK, Juno, JA, Wang, JJ, et al. Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19. Nat Commun. 2021;12(1):1162. doi: 10.1038/s41467-021-21444-5CrossRefGoogle ScholarPubMed
Quast, I, Tarlinton, D. B cell memory: understanding COVID-19. Immunity. 2021;54(2):205–210. doi: 10.1016/j.immuni.2021.01.014CrossRefGoogle ScholarPubMed
Zhao, J, Zhao, S, Ou, J, et al. COVID-19: Coronavirus vaccine development updates. Front Immunol. 2020;11:602256. doi: 10.3389/fimmu.2020.602256CrossRefGoogle ScholarPubMed
Shuangyan, L, Lin, W, Cheng, L, et al. Detection of antibodies against SARS-COV-2 as a serological maker of infection in patients with COVID-19. 2021;12:861–864. doi:Google Scholar
Baumgarth, N, Nikolich-Zugich, J, Lee, FE, et al. Antibody responses to SARS-CoV-2: let’s stick to known knowns. J Immunol. 2020;205(9):2342–2350. doi: 10.4049/jimmunol.2000839CrossRefGoogle ScholarPubMed
Normark, J, Vikstrom, L, Gwon, YD, et al. Heterologous ChAdOx1 nCoV-19 and mRNA-1273 vaccination. N Engl J Med. 2021;385(11):1049–1051. doi: 10.1056/NEJMc2110716CrossRefGoogle ScholarPubMed
Ai, J, Zhang, H, Zhang, Q, et al. Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and variants of concern. Cell Res. 2021;32(1):103–106. doi: 10.1038/s41422-021-00590-xCrossRefGoogle ScholarPubMed
Aksoyalp, ZS, Nemutlu-Samur, D. Sex-related susceptibility in coronavirus disease 2019 (COVID-19): proposed mechanisms. Eur J Pharmacol. 2021;912:174548. doi: 10.1016/j.ejphar.2021.174548CrossRefGoogle ScholarPubMed
Flanagan, KL, Fink, AL, Plebanski, M, et al. Sex and gender differences in the outcomes of vaccination over the life course. Annu Rev Cell Dev Biol. 2017;33:577–599. doi: 10.1146/annurev-cellbio-100616-060718CrossRefGoogle ScholarPubMed
Klein, SL, Marriott, I, Fish, EN. Sex-based differences in immune function and responses to vaccination. Trans R Soc Trop Med Hyg. 2015;109(1):9–15. doi: 10.1093/trstmh/tru167CrossRefGoogle ScholarPubMed
McNeil, MM, Weintraub, ES, Duffy, J, et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2016;137(3):868–878. doi: 10.1016/j.jaci.2015.07.048CrossRefGoogle ScholarPubMed
Pellini, R, Venuti, A, Pimpinelli, F, et al. Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine. EClinicalMedicine. 2021;36:100928. doi: 10.1016/j.eclinm.2021.100928CrossRefGoogle ScholarPubMed
Müller, L, Andrée, M, Moskorz, W, et al. Age-dependent immune response to the Biontech/Pfizer BNT162b2 COVID-19 vaccination. Clin Infect Dis. 2021;73(11):2065–2072. doi: 10.1101/2021.03.03.21251066CrossRefGoogle Scholar
Pera, A, Campos, C, López, N, et al. Immunosenescence: implications for response to infection and vaccination in older people. Maturitas. 2015;82(1):50–55. doi: 10.1016/j.maturitas.2015.05.004CrossRefGoogle ScholarPubMed
Collier, DA, Ferreira, I, Kotagiri, P, et al. Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature. 2021;596(7872):417–422. doi: 10.1038/s41586-021-03739-1CrossRefGoogle ScholarPubMed