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Scintigraphic Evaluation of Decontamination Lotion for Removal of Radioactive Contamination From Skin

Published online by Cambridge University Press:  31 March 2014

Sudha Rana ,
Mita Dutta ,
Navneet Sharma ,
Rajeev Goel ,
Abdul Wadood Khan ,
Sabna Kotta ,
Javed Ali ,
Shahid Husain Ansari ,
Sarwat Sultana  and
Rakesh Kumar Sharma
Sudha Rana
Affiliation:
Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
Mita Dutta
Affiliation:
Division of Chemical, Biological, Radiological, and Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
Navneet Sharma
Affiliation:
Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
Rajeev Goel
Affiliation:
Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
Abdul Wadood Khan
Affiliation:
Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India
Sabna Kotta
Affiliation:
Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India
Javed Ali
Affiliation:
Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India
Shahid Husain Ansari
Affiliation:
Department of Pharmaceutics, Jamia Hamdard University, New Delhi, India
Sarwat Sultana
Affiliation:
Department of Pharmaceutics and Medical Elementology and Toxicology, Jamia Hamdard University, New Delhi, India
Rakesh Kumar Sharma*
Affiliation:
Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
*
Correspondence and reprint requests to Rakesh Kumar Sharma, MPharm, PhD, Division of Chemical, Biological, Radiological, and Nuclear Defence, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Rd, Delhi 110 054, India (e-mail [email protected] or [email protected]).
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Abstract

Objective

Skin contamination is one of the most likely risks after accidental or occupational radiological accidents. Using scintigraphy, we assessed a topical lotion for its decontamination efficacy (DE) after exposure with short-lived medical radioisotopes technetium Tc 99m (99mTc) and thallium 201Tl (201Tl).

Methods

Using 99mTc (300 ± 5 μCi/100 μl) and 201Tl (100 ± 5 μCi/100 μl), the thoracoabdominal region (shaved skin) of Sprague Dawley rats and human tissue equivalent were contaminated and then decontaminated using cotton swabs soaked in formulated lotion at different time intervals. Static counts were recorded and calculated for DE. Histologic examination was performed on the animal model.

Results

The DE of the formulation for 99mTc and 201Tl was 85% ± 5 and 88% ± 2, respectively. The prepared formulation effectively removed the radionuclides from the tissue surface.

Conclusions

The formulated lotion assisted in the effective removal of radiocontaminants by decontaminating the radionuclides. Moreover, minimal and easily manageable radioactive waste was generated by this process. Further investigation regarding the infusion of formulated lotion into ready-to-use skin wipes for self-decontamination may be useful for mass casualty scenarios. (Disaster Med Public Health Preparedness. 2014;0:-)

Keywords

decontaminationlotionscintigraphyradionuclidesskin
Type
Original Research
Information
Disaster Medicine and Public Health Preparedness , Volume 8 , Issue 2 , April 2014 , pp. 130 - 135
Copyright
Copyright © Society for Disaster Medicine and Public Health, Inc. 2014 

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