Hostname: page-component-5c6d5d7d68-ckgrl Total loading time: 0 Render date: 2024-08-18T21:39:18.733Z Has data issue: false hasContentIssue false
  • English
  • Français

Prevalence of reduced bone mass in children and adults with spastic quadriplegia

Published online by Cambridge University Press:  29 November 2002

Wilson King ,
Ronald Levin ,
Rosemary Schmidt ,
Alan Oestreich  and
James E Heubi
Wilson King
Affiliation:
Division of Pediatric Gastroenterology, University of CincinnatiUSA.
Ronald Levin
Affiliation:
Division of Hepatology and Nutrition, University of CincinnatiUSA.
Rosemary Schmidt
Affiliation:
Division of General and Community Pediatrics, University of CincinnatiUSA.
Alan Oestreich
Affiliation:
Division of Radiology, Department of Pediatrics, University of CincinnatiUSA.
James E Heubi
Affiliation:
Clinical Research Center, Children's Hospital Medical Center, Cincinnati, OH, USA.
Get access

Abstract

This study was designed to test the hypothesis that non-ambulatory patients with spastic quadriplegia will have reduced bone mass which worsens with increasing age. Forty-eight patients (age 5 to 48 years, median age 15 years; 19 females and 29 males) were studied. Anticonvulsants were used in 29 patients (60.4%). Lumbar spine bone mineral density (LS-BMD) was markedly reduced compared with age- and sex-matched control individuals with a z score of –2.37±0.21. Twenty-eight (58%) had z scores of less than –2. A history of documented previous fracture was present in 19 patients (39%). Patients with a history of fracture had significantly lower (p=0.05) LS-BMD z scores (–2.81±0.29) compared with those without a history of fracture (–2.11±0.26). Mean serum 25-OH vitamin D was 29.6±1.9ng/mL (normal 9 to 37.6ng/mL) with three patients having serum 25-OH vitamin D levels less than 15ng/mL. These findings indicate that BMD is markedly reduced in non-ambulatory children and adults with neuromuscular disease. Reductions in bone mass put them at greater risk for non-traumatic fractures.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 45 , Issue 1 , January 2003 , pp. 12 - 16
Copyright
© 2003 Mac Keith Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)