Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-24T08:11:16.734Z Has data issue: false hasContentIssue false

Monozygotic boys with fragile X syndrome

Published online by Cambridge University Press:  16 November 2000

Laurence Sheldon
Affiliation:
South-West London and St. George's Mental Health NHS Trust, St George's Hospital, London, UK.
Jeremy Turk
Affiliation:
St. George's Hospital Medical School, London, UK.
Get access

Abstract

Monozygotic twin boys with fragile X syndrome underwent thorough genetic, psychiatric, neurological, and language evaluations at 10 years of age. They both demonstrated physical features, speech and language difficulties, social problems, and attentional deficits that characterize the behavioural phenotype of fragile X syndrome. Despite identical genetic constitutions, there were important developmental and behavioural heterogeneities. Twin A showed less social interaction and symbolic play and more speech and language dysfunction than twin B. Twin A also had significantly larger caudate volumes. It is suggested that the Xq27.3 anomaly may not be sufficient to account for all the behavioural phenotypic and neuroanatomical features of fragile X syndrome.

Type
Case Reports
Copyright
2000 Mac Keith Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)