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Intravenous lidocaine for status epilepticus during childhood

Published online by Cambridge University Press:  17 February 2006

Shin-ichiro Hamano
Affiliation:
Division of Neurology, Saitama Children's Medical Center, Japan.
Nobuyoshi Sugiyama
Affiliation:
Division of Neurology, Saitama Children's Medical Center, Japan.
Shintaro Yamashita
Affiliation:
Division of Neurology, Saitama Children's Medical Center, Japan.
Manabu Tanaka
Affiliation:
Division of Neurology, Saitama Children's Medical Center, Japan.
Mika Hayakawa
Affiliation:
Division of Neurology, Saitama Children's Medical Center, Japan.
Motoyuki Minamitani
Affiliation:
Division of Child Health and Human Development, Saitama Children's Medical Center, Japan.
Satoshi Yoshinari
Affiliation:
Department of Pediatrics, Jikei University School of Medicine, Japan.
Yoshikatsu Eto
Affiliation:
Department of Pediatrics, Jikei University School of Medicine, Japan.
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Abstract

The clinical efficacy of lidocaine for convulsive status epilepticus in 53 convulsive episodes was examined in 37 children (17 males, 20 females). Mean age of patients receiving lidocaine was 3 years 7 months (SD 3y 5mo). Lidocaine administration achieved control of status epilepticus in 19 of 53 convulsive episodes (35.8%). Seizures ceased within 5 minutes of lidocaine administration in all 19 patients who were responsive to the drug. Regarding aetiology of status epilepticus and types of seizures, there was no statistical difference in effectiveness. Mild decrease of oxygen saturation, monitored by pulse oximetry, was observed in one patient, which improved by oxygenation using a mask. Lidocaine is a useful anticonvulsive agent; however, the response rate to lidocaine appears to be quite low, as less than half of the seizures were effectively controlled by lidocaine. Favourable properties of the drug include prompt responses, less alteration of consciousness, and fewer adverse effects, including less respiratory depression.

Type
Original Articles
Copyright
2006 Mac Keith Press

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