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Effect of secretin on children with autism: a randomized controlled trial

Published online by Cambridge University Press:  13 February 2001

Jennifer Dunn-Geier ,
Helena H Ho ,
Edward Auersperg ,
David Doyle ,
Linda Eaves ,
Carey Matsuba ,
Elaine Orrbine ,
Ba' Pham  and
Sharon Whiting
Jennifer Dunn-Geier
Affiliation:
Child Development Service, Children's Hospital of Eastern Ontario, Ontario, Canada.
Helena H Ho
Affiliation:
Department of Pediatrics, University of British Columbia, British Columbia, Canada.
Edward Auersperg
Affiliation:
Ridge Meadows Hospital, Maple Ridge, British Columbia, Canada.
David Doyle
Affiliation:
Child Development Service, Children's Hospital of Eastern Ontario, Ontario, Canada.
Linda Eaves
Affiliation:
Sunny Hill Health Centre for Children, Children's and Women's Health Centre of British Columbia, British Columbia, Canada.
Carey Matsuba
Affiliation:
Department of Pediatrics, University of British Columbia, British Columbia, Canada.
Elaine Orrbine
Affiliation:
Child and Youth Clinical Trials Network, Children's Hospital of Eastern Ontario Research Institute, Ontario, Canada.
Ba' Pham
Affiliation:
Children's Hospital of Eastern Ontario Research Institute, Ontario, Canada.
Sharon Whiting
Affiliation:
Department of Pediatrics, Division of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
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Abstract

To determine the effect of intravenous porcine secretin on autistic behaviours in children aged 2 to 7 years, the effects of secretin on (1) performance on a standardized language measure, and (2) autistic behaviours, as rated by parents and child development professionals was examined. Employing a randomized, double-blind, placebo-controlled design, 95 participants were assigned to one of two groups and administered a single dose of either secretin or placebo. A follow-up assessment was conducted 3 weeks after the injection. No significant differences in language or autistic behaviour measures were observed at the 3-week follow-up between the groups. Also, there was no significant difference in the proportion of individuals who improved by [ges ] 6 points on the language measure at follow-up. This study showed no significant effects of secretin on children with autism. Our results are consistent with a systematic review of randomized controlled trials evaluating the effect of secretin in children with autism.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 42 , Issue 12 , December 2000 , pp. 796 - 802
Copyright
© 2000 Mac Keith Press

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