Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-17T14:14:07.152Z Has data issue: false hasContentIssue false
  • English
  • Français

Disabilities and cognition in children and adolescents with 22q11 deletion syndrome

Published online by Cambridge University Press:  18 February 2005

S Óskarsdóttir ,
M Belfrage ,
E Sandstedt ,
G Viggedal  and
P Uvebrant
S Óskarsdóttir
Affiliation:
The Queen Silvia Children's Hospital, Department of Paediatrics, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
M Belfrage
Affiliation:
The Queen Silvia Children's Hospital, Department of Paediatrics, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
E Sandstedt
Affiliation:
The Queen Silvia Children's Hospital, Department of Paediatrics, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
G Viggedal
Affiliation:
The Queen Silvia Children's Hospital, Department of Paediatrics, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
P Uvebrant
Affiliation:
The Queen Silvia Children's Hospital, Department of Paediatrics, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
Get access

Abstract

The purpose of this study was to investigate cognitive and other disabilities in children and adolescents with 22q11 deletion syndrome. Thirty-three children (15 females, 18 males; age range 3 to 19y, median 7y 6mo) with 22q11 deletion were investigated for growth, development, neurology, cognition, motor function, and participation (measured as handicap). Half of the children had never crawled, although they had shuffled, and commencement of walking was delayed (mean 18mo, SD6mo). Hypotonia was found in 25 and poor balance in 24 of the 33 children; 17 out of 27 had definite motor problems, including two with spastic hemiplegia. Intelligence quotient (IQ) range was 50 to 100. Eleven patients had an IQ below 70, and 15 between 70 and 84. Verbal IQ was higher than Performance IQ. Level of handicap within the study group was considered moderate, and all but one child had extra support at school. We conclude that children with 22q11 deletion syndrome have multiple neurological, motor, and cognitive problems. Although the severity and number of problems varies, the combination of impairments and disabilities results in a low level of participation.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 47 , Issue 3 , March 2005 , pp. 177 - 184
Copyright
© 2005 Mac Keith Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Handicap: the International Classification of Impairments, Disabilities and Handicaps terminology (World Health Organization 1980) was used in this study (see Method section).