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Corpus callosum may be similar in children with ADHD and siblings of children with ADHD

Published online by Cambridge University Press:  01 January 2000

S Overmeyer ,
A Simmons ,
J Santosh ,
C Andrew ,
S C R Williams ,
A Taylor ,
W Chen  and
E Taylor
S Overmeyer
Affiliation:
Department of Child Psychiatry, Institute of Psychiatry, London, SE5 8AF, UK.
A Simmons
Affiliation:
Department of Clinical Neurosciences, Institute of Psychiatry, London, SE5 8AF, UK.
J Santosh
Affiliation:
Department of Child Psychiatry, Institute of Psychiatry, London, SE5 8AF, UK.
C Andrew
Affiliation:
Department of Clinical Neurosciences, Institute of Psychiatry, London, SE5 8AF, UK.
S C R Williams
Affiliation:
Department of Clinical Neurosciences, Institute of Psychiatry, London, SE5 8AF, UK.
A Taylor
Affiliation:
Department of Child Psychiatry, Institute of Psychiatry, London, SE5 8AF, UK.
W Chen
Affiliation:
Department of Child Psychiatry, Institute of Psychiatry, London, SE5 8AF, UK.
E Taylor
Affiliation:
Department of Child Psychiatry, Institute of Psychiatry, London, SE5 8AF, UK.
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Abstract

No previous studies have used morphological neuroimaging to compare children with ADHD with siblings of children with ADHD. To test the hypothesis that the total size of the corpus callosum is altered in children with hyperkinetic disorder, the corpus callosum was outlined from a single midline proton-density weighted slice (containing the septum pellucidum). Fifteen boys with a refined phenotype of ADHD (mean age 10.2 years) and 15 healthy male siblings of children with ADHD (mean age 10.6 years) were enrolled in the study. The two groups were compared for global brain size and the callosal areas of Witelson. No significant differences were found between the study and comparison groups for any of the corpus callosum areas, even after age, global brain size, and handedness were covaried (using MANOVA). In addition, corpus callosum sizes do not seem to differ between children with ADHD and unaffected siblings of children with ADHD. Clinicians should not base their pathophysiological diagnosis of this disorder on an abnormality of callosal development.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 42 , Issue 1 , January 2000 , pp. 8 - 13
Copyright
© 2000 Mac Keith Press

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