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Autism spectrum disorders and underlying brain pathology in CHARGE association

Published online by Cambridge University Press:  19 December 2005

Maria Johansson ,
Maria Råstam ,
Eva Billstedt ,
Susanna Danielsson ,
Kerstin Strömland ,
Marilyn Miller  and
Christopher Gillberg
Maria Johansson
Affiliation:
Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden.
Maria Råstam
Affiliation:
Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden.
Eva Billstedt
Affiliation:
Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden.
Susanna Danielsson
Affiliation:
Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden.
Kerstin Strömland
Affiliation:
Department of Ophthalmology, Göteborg University, Göteborg, Sweden.
Marilyn Miller
Affiliation:
Department of Ophthalmology and Visual Sciences, Eye and Ear Infirmary, University of Illinois, Chicago, IL, USA.
Christopher Gillberg
Affiliation:
Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden.
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Abstract

The rate of autism spectrum disorders (ASDs) and brain abnormalities was analyzed in 31 individuals (15 males, 16 females; age range 1mo to 31y, mean age 8y 11mo) with CHARGE association, as part of a multidisciplinary study. A meticulous neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Judgement regarding ASDs was impossible in three infants and three patients who were deaf and blind. Five individuals met diagnostic criteria for autism, five for an autistic-like condition, and seven for autistic traits. Brain abnormalities were indicated in almost three-quarters of examined individuals, and midline abnormalities of the forebrain in one-third. Awareness of the coexistence of CHARGE and ASDs is important in habilitation care in CHARGE. Moreover, the results indicate that a subgroup of ASDs may be associated with errors in early embryonic brain development.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 48 , Issue 1 , January 2006 , pp. 40 - 50
Copyright
© 2006 Mac Keith Press

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