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Stress responsivity in children with externalizing behavior disorders

Published online by Cambridge University Press:  01 June 2004

HEDDEKE SNOEK
Affiliation:
University Medical Center Utrecht, Rudolf Magnus Institute for Neurosciences
STEPHANIE H.M. VAN GOOZEN
Affiliation:
University of Cambridge
WALTER MATTHYS
Affiliation:
University Medical Center Utrecht, Rudolf Magnus Institute for Neurosciences
JAN K. BUITELAAR
Affiliation:
University Medical Center Nijmegen
HERMAN VAN ENGELAND
Affiliation:
University Medical Center Utrecht, Rudolf Magnus Institute for Neurosciences

Abstract

Patterns of lower autonomic nervous system (ANS) and hypothalamic–pituitary–adrenal (HPA) axis activity have been found in children with oppositional defiant disorder (ODD). The aim of the present study was to investigate whether children with attention-deficit/hyperactivity disorder (ADHD) differ from ODD children with (OD/AD) or without comorbid ADHD in ANS and HPA axis activity under baseline and stressful conditions. The effects of stress on cortisol, heart rate (HR), and skin conductance level (SCL) were studied in 95 children (26 normal control [NC] children and 69 child psychiatric patients referred for externalizing behavior problems [15 ODD, 31 OD/AD, and 23 ADHD]). No baseline differences were found in cortisol between the four groups. However, the ODD and OD/AD groups showed a significantly weaker cortisol response to stress compared to the ADHD and NC groups; the ADHD group had a similar cortisol response as the NC group. Within the ODD group this pattern of low cortisol responsivity was most clearly present in the more severely affected inpatients. With respect to HR, the ODD group had a significantly lower HR during baseline and stressful conditions. The higher HR levels in the OD/AD and ADHD groups were likely to be caused by methylphenidate. The externalizing groups had significantly lower SCL levels, and no differences were found between these groups. It was concluded that differences in cortisol responsivity during stress exposure are important in distinguishing within a group of children with externalizing behavior between those with ODD and ADHD.

Type
Research Article
Copyright
© 2004 Cambridge University Press

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References

REFERENCES

Abikoff, H., & Klein, R. G. (1992). Attention-deficit hyperactivity and conduct disorder. Comorbidity and implications for treatment. Journal of Consulting and Clinical Psychology 60, 881892.CrossRefGoogle Scholar
Achenbach, T. M. (1991). Manual for the Child Behavior Checklist and Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
Biederman, J., Munir, K., & Knee, D. (1987). Conduct and oppositional disorder in clinically referred children with attention deficit disorder: A controlled family study. Journal of the American Academy of Child and Adolescent Psychiatry 26, 724727.CrossRefGoogle Scholar
Carlson, M., & Earls, F. (1997). Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania. Annals of the New York Academy of Sciences 807, 419428.CrossRefGoogle Scholar
Daugherty, T. K., & Quay, H. C. (1991). Response perseveration and delayed responding in childhood behavior disorders. Journal of Child Psychology and Psychiatry 32, 453461.CrossRefGoogle Scholar
Dodge, K. A. (1993). Social–cognitive mechanisms in the development of conduct disorder and depression. Annual Review of Psychology 44, 559584.CrossRefGoogle Scholar
Fisher, P., Wicks, B. A., Shaffer, D., Piacentini, J., & Lapkin, J. (1992). Diagnostic Interview Schedule for Children (DISC 2.3) parent version. New York: Columbia University Press (Translated into Dutch by F. C. Verhulst & M. Kasius).
Fowles, D. C., & Furuseth, A. M. (1994). Electrodermal hyporeactivity and antisocial behavior. In D. K. Routh (Ed.), Disruptive behavior disorders in childhood (pp. 181205). New York: Plenum Press.
Frick, P. J., & Loney, B. R. (1999). Outcomes of children and adolescents with oppositional defiant disorder and conduct disorder. In H.C. Quay & A.E. Hogan (Eds.), Handbook of disruptive disorders (pp. 507524). New York: Kluwer Academic/Plenum Press.
Gerra, G., Zaimovic, A., Avanzini, P, Chittolini, B., Giucastro, G., Caccavari, R., Palladino, M., Maestri, D., Monica, C., Delsignore, R., & Brambilla, F. (1997). Neurotransmitter–neuroendocrine responses to experimentally induced aggression in humans: influence of personality variable. Psychiatry Research 66, 3343.Google Scholar
Halperin, J. M., Vanshdeep, S., Siever, L. J., Schwartz, S. T., Matier, K., Wornell, G., & Newcorn, J. H. (1994). Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. The American Journal of Psychiatry 151, 243248.Google Scholar
Herpertz, S. C., Wenning, B., Mueller, B., Qunaibi, M., Sass, H., & Herpertz–Dahlmann, B. (2001). Psychophysiological responses in ADHD boys with and without conduct disorder: Implications for adult antisocial behavior. Journal of the American Academy of Child and Adolescent Psychiatry 40, 12221230.CrossRefGoogle Scholar
Hinshaw, S. P. (1992). Externalizing behavior problems and academic underachievement in childhood and adolescence: Causal relationships and underlying mechanisms. Psychological Bulletin 111, 127155.CrossRefGoogle Scholar
Iaboni, F., Douglas, V. I., & Ditto, B. (1997). Psychophysiological response of ADHD children to reward and extinction. Psychophysiology 34, 116123.CrossRefGoogle Scholar
Kariyawasam, S. H., Zaw, F., & Handley, S. L. (2002). Reduced salivary cortisol in children with comorbid attention deficit hyperactivity disorder and oppositional defiant disorder. Neuroendocrinology Letters 23, 4548.Google Scholar
Kirschbaum, C., & Hellhammer, D. H. (1989). Salivary cortisol in psychobiological research: An overview. Neuropsychobiology 22, 150169.Google Scholar
Kirschbaum, C., Steyer, R., Eid, M., Patalla, U., Schwenkmezger, P., & Hellhammer, D. H. (1990). Cortisol and behavior: 2. Application of a latent state-trait model to salivary cortisol. Psychoneuroendocrinology 15, 297307.Google Scholar
Klimes–Dougan, B., Hastings, P. D., Granger, D. A., Usher, B. A., & Zahn–Waxler, C. (2001). Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Development and Psychopathology 13, 695719.CrossRefGoogle Scholar
Kruesi, M. J. P., Hibbs, E. D., Zahn, T. P., Keysor, C. S., Hamburger, S. D., Bartko, J. J., & Rapoport, J. L. (1992). A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Archives of General Psychiatry 49, 429435.CrossRefGoogle Scholar
Kruesi, J. P., Schmidt, M. E., Donnelly, M., Hibbs, E. D., & Hamburger, S. D. (1989). Urinary free cortisol output and disruptive behavior in children. Journal of the American Academy of Child and Adolescent Psychiatry 28, 441443.CrossRefGoogle Scholar
Lahey, B. B., Loeber, R., Quay, H., Frick, P., & Grimm, J. (1992). Oppositional-defiant and conduct disorders: Issues to be resolved in DSM-IV. Journal of the American Academy of Child and Adolescent Psychiatry 31, 539546.CrossRefGoogle Scholar
Lahey, B. B., McBurnett, K., Loeber, R., & Hart, E. L. (1995). Psychobiology. In G. Pirooz Sholevar (Ed.), Conduct disorders in children and adolescents (pp. 2744). Washington, DC: American Psychiatric Press.
Loeber, R., & Stouthamer–Loeber, M. (1998). Development of juvenile aggression and violence. Some common misconceptions and controversies. The American Psychologist 53, 242259.Google Scholar
Mannuzza, S., & Klein, R. G. (1999). Adolescent and adult outcomes in attention-deficit/hyperactivity disorder. In H. C. Quay & A. E. Hogan (Eds.), Handbook of disruptive disorders (pp. 297293). New York: Kluwer Academic/Plenum Press.
Matthys, W., van Goozen, S. H. M., de Vries, H., Cohen–Kettenis, P. T., & van Engeland, H. (1998). The dominance of behavioural activation over behavioural inhibition in conduct disordered boys with and without attention deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 39, 643651.CrossRefGoogle Scholar
McBurnett, K., Lahey, B. B., Frick, P. J., Risch, C., Loeber, R., Hart, E. L., Christ, M. A. G., & Hanson, K. S. (1991). Anxiety, inhibition, and conduct disorder in children: II. Relation to salivary cortisol. Journal of the American Academy of Child and Adolescent Psychiatry 30, 192196.CrossRefGoogle Scholar
McBurnett, K., Lahey, B. B., Rathouz, P. J., & Loeber, R. (2000). Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Archives of General Psychiatry 57, 3843.CrossRefGoogle Scholar
Moss, H. B., Vanyukov, M. M., & Martin, C. S. (1995). Salivary cortisol responses and the risk for substance abuse in prepubertal boys. Biological Psychiatry 38, 547555.CrossRefGoogle Scholar
Pajer, K., Gardner, W., Rubin, R. T., Perel, J., & Neal, S. (2001). Decreased cortisol levels in adolescent girls with conduct disorder. Archives of General Psychiatry 58, 297302.CrossRefGoogle Scholar
Pennington, B. F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry, and Allied Disciplines 37, 5187.CrossRefGoogle Scholar
Raine, A. (1993). The psychopathology of crime: Criminal behavior as a clinical disorder. San Diego: Academic Press.
Raine, A. (1996). Autonomic nervous system activity and violence. In D. M. Stoff & R. B. Cairns (Eds.), Aggression and violence (pp. 145168). Mahwah, NJ: Erlbaum.
Raine, A., & Venables, P. H. (1984). Electrodermal nonresponding, antisocial behavior, and schizoid tendencies in adolescents. Psychophysiology 21, 424433.CrossRefGoogle Scholar
Raine, A., Venables, P. H., & Mednick, S. A. (1997). Low resting heart rate at age 3 years predisposes to aggression at age 11 years: Evidence from the Mauritius Child Health Project. Journal of the American Academy of Child and Adolescent Psychiatry 36, 14571464.CrossRefGoogle Scholar
Raine, A., Venables, P. H., & Williams, M. (1990). Relationships between central and autonomic measures of arousal at age 15 years and criminality at age 24 years. Archives of General Psychiatry 47, 10031007.CrossRefGoogle Scholar
Scarpa, A., Fikretoglu, D., & Luscher, K. (2000). Community violence exposure in a young adults sample: II. Psychophysiology and aggressive behavior. Journal of Community Psychology 28, 417425.Google Scholar
Scarpa, A., & Kolko, D. J. (1994). Salivary testosterone and cortisol in disruptive children: Relationship to aggressive, hyperactive, and internalizing behaviors. Journal of the American Academy of Child and Adolescent Psychiatry 33, 11741184.Google Scholar
Schachar, R. (1991). Childhood hyperactivity. Journal of Child Psychology and Psychiatry, and Allied Disciplines 32, 155191.CrossRefGoogle Scholar
Schachar, R., & Logan, G. (1990). Impulsivity and inhibitory control in normal development and childhood psychopathology. Developmental Psychology 26, 710720.CrossRefGoogle Scholar
Schachar, R., & Tannock, R. (1995). Test of four hypotheses for the comorbidity of attention-deficit hyperactivity disorders and conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry 34, 639648.CrossRefGoogle Scholar
Schulz, K. P., Halperin, J. M., Newcorn, J. H., Sharma, V., & Gabriel, S. (1997). Plasma cortisol and aggression in boys with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 36, 605609.CrossRefGoogle Scholar
Schwartz, E. B., Granger, D. A., Susman, E. J., Gunnar, M. R., & Laird, B. (1998). Assessing salivary cortisol in studies of child development. Child Development 69, 15031513.CrossRefGoogle Scholar
Stoff, D. M., Pasatiempo, A. P., Yeung, J., Cooper, T. B., Bridger, W. H., & Rabinovich, H. (1992). Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Research 43, 263276.Google Scholar
Tennes, K., & Kreye, M. (1985). Children's adrenocortical responses to classroom activities and tests in elementary school. Psychosomatic Medicine 47, 451460.CrossRefGoogle Scholar
Tennes, K., Kreye, M., Avitable, N., & Wells, R. (1986). Behavioral correlates of excreted catecholamines and cortisol in second-grade children. Journal of the American Academy of Child and Adolescent Psychiatry 25, 764770.CrossRefGoogle Scholar
Van Goozen, S. H. M., Matthys, W., Cohen–Kettenis, P. T., Buitelaar, J. K., & Van Engeland, H. (2000). Hypothalamic–pituitary–adrenal axis and autonomic nervous system activity in disruptive children and matched controls. Journal of the American Academy of Child and Adolescent Psychiatry 39, 14381445.CrossRefGoogle Scholar
Van Goozen, S. H. M., Matthys, W., Cohen–Kettenis, P. T., Gispen–de Wied, C., Wiegant, V. M., & Van Engeland, H. (1998). Salivary cortisol and cardiovascular activity during stress in oppositional defiant disorder boys and normal controls. Biological Psychiatry 43, 531539.CrossRefGoogle Scholar
Van Goozen, S. H. M., Van den Ban, E., Matthys, W., Cohen–Kettenis, P. T., Thijssen, J. H. H., & Van Engeland, H. (2000). Increased adrenal androgen functioning in children with oppositional defiant disorder: A comparison with psychiatric and normal controls. Journal of the American Academy of Child and Adolescent Psychiatry 39, 14461451.CrossRefGoogle Scholar
Vanyukov, M. M., Moss, H. B., Plail, J. A., Blackson, T., Mezzich, A. C., & Tarter, R. E. (1993). Antisocial symptoms in preadolescent boys and in their parents: Associations with cortisol. Psychiatry Research 46, 917.Google Scholar
Virkkunen, M. (1985). Urinary free cortisol secretion in habitually violent offenders. Acta Psychiatrica Scandinavica 72, 4044.CrossRefGoogle Scholar
Von Zerssen, D. (1986). Clinical self-rating scales (CSRS of the Munich psychiatric information system). In N. Sartorius & T. A. Ban (Eds.), Assessment of depression (pp. 270303). Berlin: Springer–Verlag.
Weizman, R., Dick, J., Gil-Ad, I., Weitz, R., Tyano, S., & Laron, Z. (1987). Effects of acute and chronic methylphenidate administration on β-endorphin, growth hormone, prolactin and cortisol in children with attention deficit disorder and hyperactivity. Life Sciences 40, 22472252.CrossRefGoogle Scholar
Woodman, D. D., Hinton, J. W., & O'Neill, M. T. (1978). Cortisol secretion and stress in maximum security hospital patients. Journal of Psychosomatic Research 22, 133136.CrossRefGoogle Scholar
Zahn, T. P., & Kruesi, M. J. P. (1993). Autonomic activity in boys with disruptive behavior disorders. Psychophysiology 30, 605614.CrossRefGoogle Scholar
Zuckerman, M. (1979). Sensation seeking: Beyond the optimal level of arousal. Hillsdale, NJ: Erlbaum.