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Sluggish vagal brake reactivity to physical exercise challenge in children with selective mutism

Published online by Cambridge University Press:  31 January 2012

Keri J. Heilman ,
Sucheta D. Connolly ,
Wendy O. Padilla ,
Marika I. Wrzosek ,
Patricia A. Graczyk  and
Stephen W. Porges
Keri J. Heilman*
Affiliation:
University of Illinois at Chicago
Sucheta D. Connolly
Affiliation:
University of Illinois at Chicago
Wendy O. Padilla
Affiliation:
University of Illinois at Chicago
Marika I. Wrzosek
Affiliation:
University of Illinois at Chicago
Patricia A. Graczyk
Affiliation:
University of Illinois at Chicago
Stephen W. Porges
Affiliation:
University of Illinois at Chicago
*
Address correspondence and reprint requests to: Keri J. Heilman, Brain–Body Center, MC 747, Department of Psychiatry, University of Illinois at Chicago, 1747 West Roosevelt Road, Chicago, IL 60608; E-mail: [email protected].
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Abstract

Cardiovascular response patterns to laboratory-based social and physical exercise challenges were evaluated in 69 children and adolescents, 20 with selective mutism (SM), to identify possible neurophysiological mechanisms that may mediate the behavioral features of SM. Results suggest that SM is associated with a dampened response of the vagal brake to physical exercise that is manifested as reduced reactivity in heart rate and respiration. Polyvagal theory proposes that the regulation of the vagal brake is a neurophysiological component of an integrated social engagement system that includes the neural regulation of the laryngeal and pharyngeal muscles. Within this theoretical framework, sluggish vagal brake reactivity may parallel an inability to recruit efficiently the structures involved in speech. Thus, the findings suggest that dampened autonomic reactivity during mobilization behaviors may be a biomarker of SM that can be assessed independent of the social stimuli that elicit mutism.

Type
Regular Articles
Information
Development and Psychopathology , Volume 24 , Issue 1 , February 2012 , pp. 241 - 250
Copyright
Copyright © Cambridge University Press 2012

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References

Achenbach, T. M. (1991). Integrative guide for the 1991 CBCL/4–18, YSR, and the TRF profiles. Burlington, VT: University of Vermont, Department of Psychiatry.Google Scholar
Achenbach, T. M., & Rescorla, L. A. (2000). Manual for the ASEBA preschool forms & profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.Google Scholar
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: Author.Google Scholar
Anderson, N. B. (1989). Racial differences in stress-induced cardiovascular reactivity and hypertension: Current status and substantive issues. Psychological Bulletin, 105, 89–105.Google Scholar
Angelone, A., & Coulter, N. (1994). Respiratory sinus arrhythmia: A frequency dependent phenomenon. Journal of Applied Physiology, 3, 479–482.Google Scholar
Arie, M., Henkin, Y., Lamy, D., Tetin-Schneider, S., Apter, A., Sadeh, A., et al. (2007). Reduced auditory processing capacity during vocalization in children with selective mutism. Biological Psychiatry, 61, 419–421.Google Scholar
Bar-Haim, Y., Henkin, Y., Ari-Even-Roth, D., Tetin-Schneider, S., Hildesheimer, M., & Muchnik, C. (2004). Reduced auditory efferent activity in childhood selective mutism. Biological Psychiatry, 55, 1061–1068.Google Scholar
Bergman, R. L., Piacentini, J., & McCracken, J. T. (2002). Prevalence and description of SM in a school-based sample. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 938–946.CrossRefGoogle Scholar
Black, B., & Uhde, T. W. (1995). Psychiatric characteristics of children with SM: A pilot study. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 847–856.CrossRefGoogle Scholar
Denver, J. W., Reed, S. F., & Porges, S. W. (2007). Methodological issues in the quantification of respiratory sinus arrhythmia. Biological Psychology, 74, 286–294.Google Scholar
Dummit, E. S., Klein, R. G., Tancer, N. K., Asche, B., & Martin, J. (1996). Fluoxetine treatment of children with SM: An open trial. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 615–621.Google Scholar
Dummit, E. S., Klein, R. G., Tancer, N. K., Asche, B., Martin, J., & Fairbanks, J. A. (1997). Systematic assessment of 50 children with SM. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 653–660.CrossRefGoogle Scholar
Hayano, J., Mukai, S., Sakakibara, M., Okada, A., Takata, K., & Fujinami, T. (1994). Effects of respiratory interval on vagal modulation of heart rate. American Journal of Physiology, 267, H33–H40.Google Scholar
Heilman, K. J., Bal, E., Bazhenova, O. V., Sorokin, Y., Perlman, S. B., Hanley, M. C., et al. (2008). Physiological responses to social and physical exercise challenges in children: Quantifying mechanisms supporting social engagement and mobilization behaviors. Developmental Psychobiology, 50, 171–182.CrossRefGoogle Scholar
Hirsch, J. A., & Bishop, B. (1981). Respiratory sinus arrhythmia in humans: How breathing pattern modulates heart rate. American Journal of Physiology, 241, H620–H629.Google Scholar
Kristensen, H. (2000). SM and comorbidity with developmental disorder/delay, anxiety disorder and elimination disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 249–256.Google Scholar
Kristensen, H. (2001). Multiple informants' report of emotional and behavioural problems in a nation-wide sample of selective mute children and controls. European Child & Adolescent Psychiatry, 10, 135–142.CrossRefGoogle Scholar
Obrist, P. A. (1968). Heart rate and somatic-motor coupling during classical aversive conditioning in humans. Journal of Experimental Psychology, 77, 180–193.Google Scholar
Obrist, P. A., Webb, R. A., Sutterer, J. R., & Howard, J. L. (1970). The cardiac–somatic relationship: Some reformulations. Psycbophysiology, 6, 569–587.Google Scholar
Porges, S. W. (1985). Method and apparatus for evaluating rhythmic oscillations in a periodic physiological response system. US Patent 4,510,944.Google Scholar
Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology, 32, 301–318.Google Scholar
Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74, 116–143.Google Scholar
Porges, S. W., & Bohrer, R. E. (1990). Analyses of periodic processes in psychophysiological research. In Cacioppo, J. T. & Tassinary, L. G. (Eds.), Principles of psychophysiology: Physical, social, and inferential elements (pp. 708–753). New York: Cambridge University Press.Google Scholar
Porges, S. W., & Byrne, E. A. (1992). Research methods for measurement of heart rate and respiration. Biological Psychology, 34, 93–130.Google Scholar
Porges, S. W., Doussard-Roosevelt, J. A., Portales, A. L., & Greenspan, S. I. (1996). Infant regulation of the vagal “brake” predicts child behavior problems: A psychobiological model of social behavior. Developmental Psychobiology, 29, 697–712.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Porges, S. W., & Lewis, G. F. (2009). The polyvagal hypothesis: Common mechanisms mediating autonomic regulation, vocalizations, and listening. In Brudzynski, S. M. (Ed.), Handbook of mammalian vocalizations: An integrative neuroscience approach (pp. 255–264). Amsterdam: Academic Press.Google Scholar
Poyhonen, M., Syvaoja, S., Hartikainen, J., Ruokonen, E., & Takala, J. (2004). The effect of carbon dioxide, respiratory rate and tidal volume on human heart rate variability. Acta Anaesthesiologica Scandinavica, 48, 93–101.Google Scholar
Riniolo, T. C., & Porges, S. W. (1997). Inferential and descriptive influences on measures of respiratory sinus arrhythmia: Sampling rate, R-wave trigger accuracy, and variance estimates. Psychophysiology, 34, 613–621.Google Scholar
Silverman, W. K., & Albano, A. M. (1996). The Anxiety Disorders Interview Schedule for DSM-IV: Parent Interview Schedule. San Antonio, TX: Graywind Publications.Google Scholar
Steinhausen, H., & Juzi, C. (1996). Elective mutism: An analysis of 100 cases. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 606–614.Google Scholar
Yeganeh, R., Beidel, D. C., & Turner, S. M. (2006). Selective mutism: More than social anxiety? Depression and Anxiety, 23, 117–123.CrossRefGoogle ScholarPubMed