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Prenatal exposure to alcohol and school problems in late childhood: A longitudinal prospective study

Published online by Cambridge University Press:  31 October 2008

Heather Carmichael Olson ,
Paul D. Sampson ,
Helen Barr ,
Ann P. Streissguth  and
Fred L. Bookstein
Heather Carmichael Olson*
Affiliation:
University of Washington
Paul D. Sampson
Affiliation:
University of Washington
Helen Barr
Affiliation:
University of Washington
Ann P. Streissguth
Affiliation:
University of Washington
Fred L. Bookstein
Affiliation:
University of Michigan
*
Address reprint requests to: Heather Carmichael Olson, Ph.D., University of Washington School of Medicine, Department of Psychiatry and Behavioral Sciences, Fetal Alcohol and Drug Unit, GG-20, Seatle, WA 98195.
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Abstract

The population-based Seattle Longitudinal Prospective Study on Alcohol and Pregnancy unites the fields of developmental psychopathology and behavioral teratology. Examining prenatal biological influences on childhood learning problems, this report is the first to extend earlier findings of alcohol-related deficits into late childhood. This follow-up study of 458 singletons assesses the degree to which children's classroom behavior and achievement difficulties at age 11 are predicted by prenatal alcohol exposure across the full spectrum of maternal use. Partial least squares statistical techniques are used to summarize complex multiple measures of exposure and outcome as latent variables. Accounting for many factors potentially important in development, analyses reveal a significant and subtle dose-response relationship between prenatal alcohol exposure and children's school performance a decade later. Maternal binge drinking (five or more drinks per occasion) and drinking during very early pregnancy are particularly salient for children's poorer school performance. A wide variety of problematic classroom behaviors, including attentional, activity, information-processing, and academic difficulties, are salient for prenatal alcohol exposure. Considered within the body of data on alcohol teratogenesis, these findings suggest that prenatal alcohol exposure has an enduring and predictable relationship with developmental difficulties through late childhood. Clinical, research, and public health implications are discussed.

Type
Research Article
Information
Development and Psychopathology , Volume 4 , Issue 3 , July 1992 , pp. 341 - 359
Copyright
Copyright © Cambridge University Press 1992

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References

American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (rev. 3rd ed.). Washington, DC: Author.Google Scholar
Bellinger, D., Leviton, A., Waternaux, C., Needleman, H. L., & Rabinowitz, M. (1987). Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. The New England Journal of Medicine, 316(17), 1037–1043.CrossRefGoogle ScholarPubMed
Bookstein, F. L. (1986). The elements of latent variable models. In Lamb, M., Brown, A. L., & Rogoff, B. (Eds.), Advances in developmental psychology (Vol. 4, pp. 203–230). Hillsdale, NJ: Erlbaum.Google Scholar
Bookstein, F. L., Sampson, P. D., Streissguth, A. P., & Barr, H. M. (1990). Measuring “dose” And “response” with multivariate data using partial least squares techniques. Communications in Statistics: Theory and Methods, 79(3), 765–804.CrossRefGoogle Scholar
Boyd, T. A., Ernhart, C. B., Greene, T., Sokol, R. J., & Martier, S. (1990). Prenatal alcohol exposure and sustained attention in the preschool years. Neurotoxicology and Teratology, 13(1), 49–55.CrossRefGoogle Scholar
Brown, R. T., Coles, C. D., Smith, I. E., Platzman, K. A., Silverstein, J., Erickson, S., & Falek, A. (1991). Effects of prenatal alcohol exposure at school age, II. Attention and behavior. Neurotoxicology and Teratology, 13(4), 369–375.CrossRefGoogle ScholarPubMed
Cicchetti, D. (1984). The emergence of developmental psychopathology. Child Development, 55(1), 1–7.CrossRefGoogle ScholarPubMed
Clarren, S. K. (1986). Neuropathology in the fetal alcohol syndrome. In West, J. (Ed.), Alcohol and brain development (pp. 158–166). New York: Oxford University Press.Google Scholar
Clarren, S. K., Astley, S. J., Bowden, D. M., Lai, H., Milam, A. H., Rudeen, P. K., & Shoemaker, W. J. (1990). Neuroanatomic and neurochemical abnormalities in non-human primates exposed to weekly doses of alcohol during gestation. Alcoholism: Clinical and Experimental Research, 14(5), 674–683.CrossRefGoogle Scholar
Clarren, S. K., & Smith, D. W. (1978). The fetal alcohol syndrome. The New England Journal of Medicine, 298, 1063–1067.CrossRefGoogle ScholarPubMed
Coles, C. D., Brown, I. E., Smith, I. E., Platzman, K. A., Erickson, S., & Falek, A. (1991). Effects of prenatal alcohol exposure at school age, I. Physical and cognitive development. Neurotoxicology and Teratology, 13(4), 357–366.CrossRefGoogle ScholarPubMed
Conry, J. (1990). Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects. Alcoholism: Clinical and Experimental Research, 14(5), 650–655.CrossRefGoogle ScholarPubMed
Day, N. L., Robles, N., Richardson, G., Geva, D., Taylor, P., Scher, M., Stoffer, D., Cornelius, M., & Goldschmidt, L. (1991). The effects of prenatal alcohol use on the growth of children at three years of age. Alcoholism: Clinical and Experimental Research, 15(1), 67–71.CrossRefGoogle ScholarPubMed
Dietrich, K. N., Succop, P. A., Berger, O. G., Hammond, P. B., & Bornschein, R. L. (1991). Lead exposure and the cognitive development of urban preschool children: The Cincinnati Lead Study cohort at age 4 years. Neurotoxicology and Teratology, 13(2), 203–210.CrossRefGoogle ScholarPubMed
Dohorty, M. A., & Margolis, H. (1981). Reading Improvement, 18(2), 157–160.Google Scholar
Driscoll, C. D., Streissguth, A. P., & Riley, E. P. (1990). Prenatal alcohol exposure: Comparability of effects in humans and animal models. Neurotoxicology and Teratology, 12(3), 231–235.CrossRefGoogle ScholarPubMed
Efron, B., & Tibshirani, R. (1986). Bootstrap methods for standard errors, confidence intervals and other measures of statistical accuracy. Statistical Sciences, 1, 54–77.Google Scholar
Ernhardt, C. B., Wolf, A. W., Linn, P. L., Sokol, R. J., Kennard, M. J., & Filipovich, H. F. (1985). Alcohol-related birth defects: Syndromal anomalies, intrauterine growth retardation, and neonatal behavioral assessment. Alcoholism: Clinical and Experimental Research, 9(5), 447–453.CrossRefGoogle Scholar
Fried, P. A., & O'Connell, C. M. (1987). A comparison of the effects of prenatal exposure to tobacco, alcohol, cannabis and caffeine on birth size and subsequent growth. Neurotoxicology and Teratology, 9(4), 79–85.CrossRefGoogle ScholarPubMed
Fried, P. A., & Watkinson, B. (1990). 36- and 48- month neurobehavioral follow-up of children prenatally exposed to marijuana, cigarettes and alcohol. Developmental and Behavioral Pediatrics, 11(2), 49–58.Google ScholarPubMed
Garmezy, N., Masten, A. S., & Tellegen, A. (1984). The study of stress and competence in children: A building block for developmental psychopathology. Child Development, 55(1), 97–111.CrossRefGoogle Scholar
Greene, T. H., Ernhart, C. B., Ager, J., Sokol, R. J., Martier, S., & Boyd, T. A. (1990). Prenatal exposure to alcohol and cognitive development. Neurotoxicology and Teratology, 13(1), 57–68.CrossRefGoogle Scholar
Greene, T. H., Ernhart, C. B., Martier, S., Sokol, R. J., & Ager, J. (1990). Prenatal alcohol exposure and language development. Alcoholism: Clinical and Experimental Research, 14(6), 937–945.CrossRefGoogle ScholarPubMed
Joreskog, K. G., & Sorbom, D. (1984). LISREL VI: Analysis of linear structural relationships by maximum likelihood, instrumental variables, and least squares methods (3rd ed.). Mooresville, IN: Scientific Software.Google Scholar
Ketterlinus, R. D., Bookstein, F. L., Sampson, P. D., & Lamb, M. E. (1989). Partial least squares analysis in developmental psychopathology. Development and Psychopathology, 1, 351–371.CrossRefGoogle Scholar
Landesman-Dwyer, S., Keller, L. S., & Streissguth, A. P. (1978). Naturalistic observations of newborns: Effects of maternal alcohol intake. Alcoholism: Clinical and Experimental Research, 2, 171–177.CrossRefGoogle ScholarPubMed
Little, R. E., Uhl, C. N., Labbe, R. F., Abkowitz, J. L., & Phillips, L. R. (1986). Agreement between laboratory tests and self-reports of alcohol, tobacco, caffeine, marijuana and other drug use in post-partum women. Social Science Medicine, 22(1), 91–98.CrossRefGoogle ScholarPubMed
Lohmoller, J. B. (1984). L VPLS program manual: Latent variables path analysis with partial least-square estimation. Koln: Zentralarchiv fur Empirische Sozialforschung, Universitat zu Koln. (Available in USA from Dr. J. J. Mcardle, 1929 Lewis Mountain Rd., Charlottesville, VA 22901)Google Scholar
Mardia, K. V., Kent, J. T., & Bibby, J. M. (1979). Multivariate analysis. New York: Academic.Google Scholar
Mirsky, A. (1989). The neuropsychology of attention: Implications for the development of neuropsychiatric disorders. Presentation given at the 97th American Psychological Association,New Orleans, LA.Google Scholar
Myklebust, H. R. (1981). The Pupil Rating Scale revised: Screening for learning disabilities. San Antonio, TX: The Psychological Corporation.Google Scholar
Nanson, J. L., & Hiscock, M. (1990). Attention deficits in children exposed to alcohol prenatally. Alcoholism: Clinical and Experimental Research, 14(5), 656–661.CrossRefGoogle ScholarPubMed
Needleman, H. L., Gunnoe, C., Leviton, A., Reed, R., Peresie, H., Maher, C., & Barrett, P. (1979). Deficits in psychologic and classroom performance of children with elevated dentine lead levels. The New England Journal of Medicine, 300(13), 689–695.CrossRefGoogle ScholarPubMed
O'Connor, M. J., Brill, N. J., & Sigman, M. (1986). Alcohol use in primiparous women older than 30 years of age: Relation to infant development. Pediatrics, 78(3), 444–450.CrossRefGoogle ScholarPubMed
O'Connor, M. J., & Kasari, C. (1990). Attachment behavior of infants exposed to alcohol prenatally mediating effects of infant affect and mother-infant interaction. Presented at the biennial meeting of the International Conference on Infant Studies,Montreal, Canada.Google Scholar
Ouellette, E. M., Rosett, H. L., Rosman, N. P., & Weiner, L. (1977). Adverse effects on offspring of maternal alcohol abuse during pregnancy. The New England Journal of Medicine, 297(10), 528–530.CrossRefGoogle ScholarPubMed
Riley, E. P. (1990). The long-term behavioral effects of prenatal alcohol exposure in rats. Alcoholism: Clinical and Experimental Research, 14(5), 670–673.CrossRefGoogle ScholarPubMed
Russell, M., Czarnecki, D. M., Cowan, R., McPherson, E., & Mudar, P. J. (1991). Measures of maternal alcohol use as predictors of development in early childhood. Alcoholism: Clinical and Experimental Research, 15, 991–1000.CrossRefGoogle ScholarPubMed
Sampson, P. D., Streissguth, A. P., Barr, H. M., & Bookstein, F. L. (1989). Neurobehavioral effects of prenatal alcohol. Part II: Partial least squares analysis. Neurotoxicology and Teratology, 11, 477–491.CrossRefGoogle ScholarPubMed
Sampson, P. D., Streissguth, A. P., Vega-Gonzalez, S. C., Barr, H. M., & Bookstein, F. L. (1987). Predicting classroom behavior ratings by prenatal alcohol exposure: Latent variable modeling and non-linear scaling (Tech. Rep. No. 103). Seattle: University of Washington, Department of Statistics.Google Scholar
Semrud-Clikeman, M., & Hynd, G. W. (1990). Right hemispheric dysfunction in nonverbal learning disabilities: Social, academic and adaptive functioning in adults and children. Psychological Bulletin, 107(2), 196–209.CrossRefGoogle ScholarPubMed
Shaywitz, S. E. (1986). Early recognition of educational yulnerability—EREV (Tech. Rep.). Hartford, CT: State Department of Education.Google Scholar
Shaywitz, S. E., Cohen, D. J., & Shaywitz, B. A. (1980). Behavior and learning difficulties in children of normal intelligence born to alcoholic mothers. Journal of Pediatrics, 96(6), 978–982.CrossRefGoogle ScholarPubMed
Shaywitz, S. E., Shaywitz, B. A., Fletcher, J. M., & Escobar, M. D. (1990). Prevalence of reading disabilities in males and females: Results of the Connecticut longitudinal study. Journal of the American Medical Association, 264(8), 998–1002.CrossRefGoogle ScholarPubMed
Sroufe, L. A., & Rutter, M. (1984). The domain of developmental psychopathology. Child Development, 55(1), 17–29.CrossRefGoogle ScholarPubMed
Streissguth, A. P. (1986). The behavioral teratology of alcohol: Performance, behavioral and intellectual deficits in prenatally exposed children. In West, J. (Ed.), Alcohol and brain development (pp. 3–44). New York: Oxford University Press.Google Scholar
Streissguth, A. P., Aase, J. M., Clarren, S. K., Randels, S. P., LaDue, R. A., & Smith, D. W. (1991). Fetal alcohol syndrome in adolescents and adults. The Journal of the A merican Medical Association, 265(15), 1961–1967.CrossRefGoogle ScholarPubMed
Streissguth, A. P., Barr, H. M., & Martin, D. C. (1983). Maternal alcohol use and neonatal habituation assessed with the Brazelton Scale. Child Development, 54, 1109–1118.CrossRefGoogle ScholarPubMed
Streissguth, A. P., Barr, H. M., & Sampson, P. D. (1990). Moderate prenatal alcohol exposure: Effects on child IQ and learning problems at age 71/2 years. Alcoholism: Clinical and Experimental Research, 14(5), 662–669.CrossRefGoogle Scholar
Streissguth, A. P., Barr, H. M., Sampson, P. D., Bookstein, F. L., & Darby, B. L. (1989). Neurobehavioral effects of prenatal alcohol, Part I: Research strategy. Neurotoxicology and Teratology, 11(5), 461–476.CrossRefGoogle ScholarPubMed
Streissguth, A. P., Barr, H. M., Sampson, P. D., Darby, B. L., & Martin, D. C. (1989). IQ at age four in relation to maternal alcohol use and smoking during pregnancy. Developmental Psychology, 25(1), 3–11.CrossRefGoogle Scholar
Streissguth, A. P., Barr, H. M., Sampson, P. D., Parrish-Johnson, J. C., Kirchner, G. L., & Martin, D. C. (1986). Attention, distraction and reaction time at age 7 years and prenatal alcohol exposure. Neurobehavioral Toxicology and Teratology, 8, 717–725.Google ScholarPubMed
Streissguth, A. P., Bookstein, F. L., Sampson, P. D., & Barr, H. M. (1989). Neurobehavioral effects of prenatal alcohol, Part 3: PLS analyses. Neurotoxicology and Teratology, 11(5), 493–507.CrossRefGoogle Scholar
Streissguth, A. P., & La Due, R. (1987). Fetal alcohol: Teratogenic causes of developmental disabilities. In Schroeder, S. R. (Ed.), Toxic substances and mental retardation (pp. 1–32). Washington, DC: American Association on Mental Deficiency.Google Scholar
Streissguth, A. P., Martin, D. C., Barr, H. M., Sandman, B. M., Kirchner, G. L., & Darby, B. L. (1984). Intrauterine alcohol and nicotine exposure: Attention and reaction time in 4-year-old children. Developmental Psychology, 20, 533–541.CrossRefGoogle Scholar
Streissguth, A. P., Martin, D. C., & Buffington, V. E. (1976). Test-retest reliability of three scales derived from a quantity-frequency-variability assessment of self-reported alcohol consumption. Annals of the New York Academy of Sciences, 273, 458–466.CrossRefGoogle ScholarPubMed
Streissguth, A. P., Martin, D. C., Martin, J. C., & Barr, H. M. (1981). The Seattle Longitudinal Prospective Study on Alcohol and Pregnancy. Neuro-behavioral Toxicology, 3, 223–233.Google ScholarPubMed
Streissguth, A. P., Sampson, P. D., Barr, H. M., Bookstein, F. L., & Carmichael Olson, H. (in press). Effects of prenatal alcohol versus tobacco on children: Contributions from the Seattle Longitudinal Prospective Study and implications for public policy. In Needleman, H. L. & Bellinger, D. (Eds.), Prenatal exposure to pollutants. Baltimore: Johns Hopkins University Press.Google Scholar
Streissguth, A. P., Sampson, P. D., Barr, H. M., Clarren, S. K., & Martin, D. C. (1986). Studying alcohol teratogenesis from the perspective of the fetal alcohol syndrome: Methodological and statistical issues. Annals of the New York Academy of Sciences, 477, 63–86.CrossRefGoogle ScholarPubMed
Vorhees, C. V., & Mollnow, E. (1987). Behavioral teratogenesis: Long term influences on behavior from early exposure to environmental agents. In Osofsky, J. D. (Ed.), Handbook of infant development (2nd ed., pp. 913–971). New York: Wiley.Google Scholar
West, J. R., Goodlett, C. R., Bonthius, D. J., & Pierce, D. R. (1990). Manipulating peak blood alcohol concentrations in neonatal rats: Review of an animal model for alcohol-related developmental effects. Neurotoxicology, 10, 347–366.Google Scholar
West, J. R., Goodlett, C. R., & Brandt, J. P. (1990). New approaches to research on the long-term consequences of prenatal exposure to alcohol. Alcoholism: Clinical and Experimental Research, 14(5), 684–689.CrossRefGoogle ScholarPubMed
Wold, H. (1975). Path models with latent variables: The NIPALS approach. In Blalock, H. M. et al. (Eds.), Quantitative sociology: International perspectives on mathematical and statistical modeling (pp. 307–357). New York: Academic.CrossRefGoogle Scholar