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Parent and peer influences on emerging adult substance use disorder: A genetically informed study

Published online by Cambridge University Press:  12 January 2016

Kaitlin Bountress ,
Laurie Chassin  and
Kathryn Lemery-Chalfant
Kaitlin Bountress*
Affiliation:
Medical University of South Carolina
Laurie Chassin
Affiliation:
Arizona State University
Kathryn Lemery-Chalfant
Affiliation:
Arizona State University
*
Address correspondence and reprint requests to: Kaitlin Bountress, National Crime Victim Research and Treatment Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425; E-mail: [email protected].
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Abstract

The present study utilizes longitudinal data from a high-risk community sample to examine the unique effects of genetic risk, parental knowledge about the daily activities of adolescents, and peer substance use on emerging adult substance use disorders (SUDs). These effects are examined over and above a polygenic risk score. In addition, this polygenic risk score is used to examine gene–environment correlation and interaction. The results show that during older adolescence, higher adolescent genetic risk for SUDs predicts less parental knowledge, but this relation is nonsignificant in younger adolescence. Parental knowledge (using mother report) mediates the effects of parental alcohol use disorder (AUD) and adolescent genetic risk on risk for SUD, and peer substance use mediates the effect of parent AUD on offspring SUD. Finally, there are significant gene–environment interactions such that, for those at the highest levels of genetic risk, less parental knowledge and more peer substance use confers greater risk for SUDs. However, for those at medium and low genetic risk, these effects are attenuated. These findings suggest that the evocative effects of adolescent genetic risk on parenting increase with age across adolescence. They also suggest that some of the most important environmental risk factors for SUDs exert effects that vary across level of genetic propensity.

Type
Regular Articles
Information
Development and Psychopathology , Volume 29 , Special Issue 1: Developmental and Social–Ecological Perspectives on Children, Political Violence, and Armed Conflict , February 2017 , pp. 121 - 142
Copyright
Copyright © Cambridge University Press 2016 

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