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Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits

Published online by Cambridge University Press:  15 October 2012

Becky C. Carlyle ,
Alvaro Duque ,
Robert R. Kitchen ,
Kelly A. Bordner ,
Daniel Coman ,
Eliza Doolittle ,
Xenophonios Papademetris ,
Fahmeed Hyder ,
Jane R. Taylor  and
Arthur A. Simen
Becky C. Carlyle*
Affiliation:
Yale University School of Medicine
Alvaro Duque
Affiliation:
Yale University School of Medicine
Robert R. Kitchen
Affiliation:
Yale University School of Medicine
Kelly A. Bordner
Affiliation:
Yale University School of Medicine Southern Connecticut State University
Daniel Coman
Affiliation:
Yale University School of Medicine
Eliza Doolittle
Affiliation:
Yale University School of Medicine
Xenophonios Papademetris
Affiliation:
Yale University School of Medicine
Fahmeed Hyder
Affiliation:
Yale University School of Medicine
Jane R. Taylor
Affiliation:
Yale University School of Medicine
Arthur A. Simen*
Affiliation:
Yale University School of Medicine Merck Research Labs
*
Address correspondence and reprint requests to: Becky C. Carlyle, Connecticut Mental Health Centre, Room 309, 34 Park Street, New Haven, CT 06508; E-mail: [email protected]; or Arthur Simen, Merck Research Labs, 351 North Sumneytown Pike, North Wales, PA 19454; E-mail: [email protected].
Address correspondence and reprint requests to: Becky C. Carlyle, Connecticut Mental Health Centre, Room 309, 34 Park Street, New Haven, CT 06508; E-mail: [email protected]; or Arthur Simen, Merck Research Labs, 351 North Sumneytown Pike, North Wales, PA 19454; E-mail: [email protected].
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Abstract

Child neglect is the most prevalent form of child maltreatment in the United States, and poses a serious public health concern. Children who survive such episodes go on to experience long-lasting psychological and behavioral problems, including higher rates of post-traumatic stress disorder symptoms, depression, alcohol and drug abuse, attention-deficit/hyperactivity disorder, and cognitive deficits. To date, most research into the causes of these life-long problems has focused on well-established targets such as stress responsive systems, including the hypothalamus–pituitary–adrenal axis. Using the maternal separation and early weaning model, we have attempted to provide comprehensive molecular profiling of a model of early-life neglect in an organism amenable to genomic manipulation: the mouse. In this article, we report new findings generated with this model using chromatin immunoprecipitation sequencing, diffuse tensor magnetic resonance imaging, and behavioral analyses. We also review the validity of the maternal separation and early weaning model, which reflects behavioral deficits observed in neglected humans including hyperactivity, anxiety, and attentional deficits. Finally, we summarize the molecular characterization of these animals, including RNA profiling and label-free proteomics, which highlight protein translation and myelination as novel pathways of interest.

Type
Articles
Information
Development and Psychopathology , Volume 24 , Issue 4: Contributions of the Genetic/Genomic Sciences to Developmental Psychopathology , November 2012 , pp. 1401 - 1416
Copyright
Copyright © Cambridge University Press 2012

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