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The interactive effects of child maltreatment and the FK506 binding protein 5 gene (FKBP5) on dissociative symptoms in adolescence

Published online by Cambridge University Press:  20 October 2016

Fatima Tuba Yaylaci ,
Dante Cicchetti ,
Fred A. Rogosch ,
Okan Bulut  and
Susan R. Hetzel
Fatima Tuba Yaylaci*
Affiliation:
University of Minnesota Institute of Child Development
Dante Cicchetti*
Affiliation:
University of Minnesota Institute of Child Development University of Rochester Mt. Hope Family Center
Fred A. Rogosch
Affiliation:
University of Rochester Mt. Hope Family Center
Okan Bulut
Affiliation:
University of Alberta Centre for Research in Applied Measurement and Evaluation
Susan R. Hetzel
Affiliation:
University of Minnesota
*
Address correspondence and reprint requests to: Fatima Tuba Yaylaci, Institute of Child Development, 51 East River Road, Minneapolis, MN 55455; E-mail: [email protected]; or Dante Cicchetti, Institute of Child Development, 51 East River Road, Minneapolis, MN 55455; E-mail: [email protected].
Address correspondence and reprint requests to: Fatima Tuba Yaylaci, Institute of Child Development, 51 East River Road, Minneapolis, MN 55455; E-mail: [email protected]; or Dante Cicchetti, Institute of Child Development, 51 East River Road, Minneapolis, MN 55455; E-mail: [email protected].
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Abstract

The FK506 binding protein 5 gene (FKBP5) has been associated with susceptibility to pathogenic effects of childhood trauma including dissociative symptoms. This study examines the impact of maltreatment on dissociative tendencies in adolescence as moderated by the FKBP5 gene. Dissociative symptoms and variation within FKBP5 were assessed in a high-risk, low socioeconomic status community sample of 279 maltreated and 171 nonmaltreated adolescents. Following the assignment of haplotypes across four single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080), individuals with one or more copies of the CATT haplotype (N = 230) were grouped together and compared to individuals with zero copies of this haplotype (N = 185). Analyses of covariance were conducted to test hypotheses regarding the effects of developmental timing and the chronicity of maltreatment and the CATT haplotype. We found a significant interactive effect of timing/chronicity of maltreatment and the CATT haplotype on dissociative symptoms. Among adolescents who had no copies of the CATT haplotype, dissociative symptoms were higher for chronically maltreated adolescents who had an infancy onset compared to those who were not maltreated or whose maltreatment experience was either relatively less chronic or not started in infancy. The groups did not differ significantly among subjects who carry one or more copies of the CATT haplotype.

Type
Regular Articles
Information
Development and Psychopathology , Volume 29 , Issue 3 , August 2017 , pp. 1105 - 1117
Copyright
Copyright © Cambridge University Press 2016 

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Footnotes

This research was supported by funding from the National Institute on Drug Abuse (DA12903) and the Spunk Fund, Inc.

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