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Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females

Published online by Cambridge University Press:  31 January 2012

Jamie Vaske ,
Jamie Newsome  and
John Paul Wright
Jamie Vaske*
Affiliation:
Western Carolina University
Jamie Newsome
Affiliation:
University of Cincinnati
John Paul Wright
Affiliation:
University of Cincinnati
*
Address correspondence and reprint requests to: Jamie Vaske, Department of Criminology and Criminal Justice, Western Carolina University, 410 A Belk, Cullowhee, NC 28723; E-mail: [email protected].
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Abstract

Childhood neglect has been cited as a risk factor for later substance abuse and criminal behavior. However, a large body of literature shows that a substantial percentage of neglected and abused individuals do not go on to abuse substances or engage in criminal behavior. The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of childhood neglect on alcohol use problems, marijuana use, and criminal behavior. Data from the National Longitudinal Study of Adolescent Health shows that 5-HTTLPR conditions the effect of neglect on marijuana use for females, but not for males. Findings also reveal a significant gene–environment correlation between 5-HTTLPR and neglect for females only. These results suggest that 5-HTTLPR is associated with an increased risk of neglect for females, and it also increases neglected females’ risk of abusing marijuana.

Type
Regular Articles
Information
Development and Psychopathology , Volume 24 , Issue 1 , February 2012 , pp. 181 - 193
Copyright
Copyright © Cambridge University Press 2012

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References

Add Health Biomarker Team. (n.d.). Biomarkers in wave III of the Add Health Study. Chapel Hill, NC: Population Center, University of North Carolina at Chapel Hill.Google Scholar
Agnew, R. S. (1992). Foundation for a general strain theory of crime and delinquency. Criminology, 30, 47–87.Google Scholar
Agnew, R. S. (1997). Stability and change in crime over the life course: A strain theory explanation. In Thornberry, T. P. (Ed.), Developmental theories of crime and delinquency (pp. 101–132). New Brunswick, NJ: Transaction Publishers.Google Scholar
Andersen, S. L., & Teicher, M. H. (2009). Desperately driven and no brakes: Developmental stress exposure and subsequent risk for substance abuse. Neuroscience and Biobehavioral Reviews, 33, 516–524.Google Scholar
Barr, C. S., Newman, T. K., Lindell, S., Shannon, C., Champoux, M., Lesch, K. P., et al. (2004). Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Archives of General Psychiatry, 61, 1146–1152.Google Scholar
Barr, C. S., Newman, T. K., Schwandt, M., Shannon, C., Dvoskin, R. L., Lindell, S. G., et al. (2004). Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America, 101, 12358–12363.CrossRefGoogle ScholarPubMed
Beaver, K. M. (2008a). The interaction between genetic risk and childhood sexual abuse in the prediction of adolescent violent behavior. Sexual Abuse: A Journal of Research and Treatment, 20, 426–443.CrossRefGoogle ScholarPubMed
Beaver, K. M. (2008b). Nonshared environmental influences on adolescent and delinquent involvement and adult criminal behavior. Criminology, 46, 341–369.Google Scholar
Belknap, J., & Holsinger, K. (1998). An overview of delinquent girls: How theory and practice have failed and the need for innovative changes. In Zaplin, R. (Ed.), Female offenders: Critical perspectives and effective interventions (pp. 31–64). Gathersburg, MD: Aspen.Google Scholar
Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., et al. (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry, 7, 118–122.CrossRefGoogle ScholarPubMed
Bernstein, D. P., Ahluvalia, T., Pogge, D., & Handelsman, L. (1997). Validity of the Childhood Trauma Questionnaire in an adolescent psychiatric population. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 340–348.CrossRefGoogle Scholar
Bernstein, D. P., Fink, L., Handelsman, L., & Fotte, J. (1994). Initial reliability and validity of a new retrospective measure of child abuse and neglect. American Journal of Psychiatry, 151, 1132–1136.Google ScholarPubMed
Biver, F., Lotstra, F., Monclus, M., Wikler, D., Damhaut, P., Mendlewicz, J., et al. (1996). Sex difference in 5HT2 receptor in the living human brain. Neuroscience Letters, 204, 25–28.CrossRefGoogle ScholarPubMed
Brendgen, M., Boivin, M., Vitaro, F., Girard, A., Dionne, G., & Pérusse, D. (2008). Gene–environment interaction between peer victimization and child aggression. Development and Psychopathology, 20, 455–471.CrossRefGoogle ScholarPubMed
Broidy, L., & Agnew, R. (1997). Gender and crime: A general strain theory perspective. Journal of Research in Crime and Delinquency, 34, 275–306.CrossRefGoogle Scholar
Brown, G. W., Craig, T. K. J., Harris, T. O., Handley, R. V., & Harvey, A. L. (2007). Validity of retrospective measures of early maltreatment and depressive episodes using the childhood experience of care and abuse (CECA) instrument—A life-course study of adult chronic depression—2. Journal of Affective Disorders, 103, 217–224.CrossRefGoogle ScholarPubMed
Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K., et al. (2003). Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry, 44, 88–101.CrossRefGoogle Scholar
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.CrossRefGoogle ScholarPubMed
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H. L., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.CrossRefGoogle ScholarPubMed
Champagne, F. A., & Curley, J. P. (2009). Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neuroscience and Biobehavioral Reviews, 33, 593–600.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., Lynch, M., & Holt, K. D. (1993). Resilience in maltreated children: Processes leading to adaptive outcome. Development and Psychopathology, 5, 629–647.Google Scholar
Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. L. (2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds. Development and Psychopathology, 19, 1161–1180.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Toth, S. L. (1995). A developmental psychopathology perspective on child abuse and neglect. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 541–565.Google Scholar
Clogg, C. C., Petkova, E., & Haritou, A. (1995). Statistical methods for comparing regression coefficients between models. American Journal of Sociology, 100, 1261–1293.CrossRefGoogle Scholar
Collinshaw, S., Pickles, A., Messer, J., Rutter, M., Shearer, C., & Maughan, B. (2007). Resilience to adult psychopathology following childhood maltreatment: Evidence from a community sample. Child Abuse & Neglect, 31, 211–229.CrossRefGoogle Scholar
Comings, D. E., Gade-Andavolu, R., Gonzalez, N., Wu, S., Muhleman, D., Blake, H., et al. (2000). Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: Multivariate regression analysis of 20 genes. Clinical Genetics, 57, 178–196.Google Scholar
David, S. P., Murthy, N. V., Rabiner, E. A., Munafo, M. R., Johnstone, E. C., Jacob, R., et al. (2005). A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. Journal of Neuroscience, 25, 2586–2590.CrossRefGoogle ScholarPubMed
Ducci, F., Enoch, M. A., Hodgkinson, C., Xu, K., Catena, M., Robin, R. W., et al. (2008). Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Molecular Psychiatry, 13, 334–347.Google Scholar
Dube, S. R., Felitti, V. J., Dong, M., Chapman, D. P., Giles, W. H., & Anda, R. F. (2003). Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: The Adverse Childhood Experiences study. Pediatrics, 111, 564–572.Google Scholar
DuMont, K. A., Widom, C. S., & Czaja, S. J. (2007). Predictors of resilience in abused and neglected children grown-up: The role of individual and neighborhood characteristics. Child Abuse & Neglect, 31, 255–274.CrossRefGoogle ScholarPubMed
Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., et al. (2004). Gene–environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908–915.CrossRefGoogle ScholarPubMed
English, D. J., Widom, C. S., & Brandford, C. (2001). Childhood victimization and delinquency, adult criminality, and violent criminal behavior: A replication and extension: Final report. Washington, DC: National Institute of Justice.Google Scholar
Fischette, C. T., Biegon, A., & McEwen, B. S. (1983). Sex differences in serotonin 1 receptor binding in rat brain. Science, 222, 333–335.Google Scholar
Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., et al. (2004). Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738–744.CrossRefGoogle ScholarPubMed
Gelernter, J., Kranzler, H., Coccaro, E. F., Siever, L. J., & New, A. S. (1998). Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. American Journal of Psychiatry, 155, 1332–1338.Google Scholar
Gerra, G., Garofano, L., Santoro, G., Bosari, S., Pellegrini, C., Zaimovic, A., et al. (2004). Association between low-activity serotonin transporter genotype and heroin dependence: Behavioral and personality correlates. American Journal of Medical Genetics Part B, 126B, 37–42.CrossRefGoogle ScholarPubMed
Gillespie, N. A., Whitfield, J. B., Williams, B., Heath, A. C., & Martin, N. G. (2005). The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychological Medicine, 35, 101–111.CrossRefGoogle ScholarPubMed
Gonda, X., Juhasz, G., Laszik, A., Rihmer, Z., & Bagdy, G. (2005). Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene. Journal of Affective Disorders, 87, 291–297.Google Scholar
Guo, G., Wilhelmsen, K., & Hamilton, N. (2007). Gene–lifecourse interaction for alcohol consumption in adolescence and young adulthood: Five monoamine genes. American Journal of Medical Genetics Part B, 144, 417–423.Google Scholar
Haberstick, B. C., Lessem, J. M., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D., et al. (2005). Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 135, 59–64.CrossRefGoogle Scholar
Haberstick, B. C., Smolen, A., & Hewitt, J. K. (2006). Family-based association test of the 5-HTTLPR and aggressive behavior in a general population sample of children. Biological Psychiatry, 59, 836–843.CrossRefGoogle Scholar
Hammen, C., Ellicott, A., Gitlin, M., & Jamison, K. R. (1989). Sociotropy/autonomy and vulnerability to specific life events in patients with unipolar depression and bipolar disorders. Journal of Abnormal Psychology, 98, 154–160.CrossRefGoogle ScholarPubMed
Harris, K. M., Florey, F., Tabor, J., Bearman, P. S., Jones, J., & Udry, J. R. (2003). The National Longitudinal Study of Adolescent Health: Research design. Retrieved from http://www.Cpc.Unc.edu/projects/addhealth/designGoogle Scholar
Hildyard, K. L., & Wolfe, D. A. (2002). Child neglect: Developmental issues and outcomes. Child Abuse & Neglect, 26, 679–695.Google Scholar
Horwitz, A. V., Widom, C. S., McLaughlin, J., & White, H. R. (2001). The impact of childhood abuse and neglect on adult mental health: A prospective study. Journal of Health and Social Behavior, 42, 184–201.Google Scholar
Hu, X., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., et al. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive–compulsive disorder. American Journal of Human Genetics, 78, 815–826.Google Scholar
Ichise, M., Vines, D. C., Gura, T., Anderson, G. M., Suomi, S. J., Higley, J. D., et al. (2006). Effects of early life stress on [11C] DASB positron emission tomography imaging of serotonin transporters in adolescent peer-and mother-reared rhesus monkeys. Journal of Neuroscience, 26, 4638–4643.Google Scholar
Jaffee, S. R., Caspi, A., Moffitt, T. E., Dodge, K. A., Rutter, M., Taylor, A., et al. (2005). Nature × Nurture: Genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Development and Psychopathology, 17, 67–84.Google Scholar
Jaffee, S. R., Caspi, A., Moffitt, T. E., & Taylor, A. (2004). Physical maltreatment victim to antisocial child: Evidence of an environmentally mediated process. Journal of Abnormal Psychology, 113, 44–55.Google Scholar
Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Crouse-Artus, M., Lipschitz, D., Krystal, J. H., et al. (2007). Genetic and environmental predictors of early alcohol use. Biological Psychiatry, 61, 1228–1234.Google Scholar
Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., et al. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America, 101, 17316–17321.CrossRefGoogle ScholarPubMed
Kendler, K. S., & Prescott, C. A. (2006). Genes, environment, and psychopathology: Understanding the causes of psychiatric and substance use disorders. New York: Guilford Press.Google Scholar
Kingree, J. B., Phan, D., & Thompson, M. (2003). Child maltreatment and recidivism among adolescent detainees. Criminal Justice and Behavior, 30, 623–643.Google Scholar
Kinnally, E. L., Lyons, L. A., Abel, K., Mendoza, S., & Capitanio, J. P. (2008). Effects of early experience and genotype on serotonin transporter regulation in infant rhesus macaques. Genes, Brain and Behavior, 7, 481–486.Google Scholar
Kinnally, E. L., Tarara, E. R., Mason, W. A., Mendoza, S. P., Abel, K., Lyons, L. A., et al. (2010). Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques. Genes, Brain and Behavior, 9, 45–52.Google Scholar
Kurtz, P. D., Kurtz, G. L., & Jarvis, S. V. (1991). Problems of maltreated runaway youth. Adolescence, 26, 543–555.Google ScholarPubMed
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.CrossRefGoogle ScholarPubMed
Maestripieri, D. (2005). Neuroendocrine mechanisms underlying the intergenerational transmission of maternal behavior and infant abuse in rhesus macaques. In Pfaff, D., Kordon, C., Chanson, P., & Christen, Y. (Eds.), Research and perspectives in endocrine interactions: Hormones and social behavior (pp. 121–131). New York: Springer.Google Scholar
Matthews, K., Dalley, J. W., Matthews, C., Tsai, T. H., & Robbins, T. W. (2001). Periodic maternal separation of neonatal rats produces region and gender specific effects on biogenic amine content in postmortem adult brain. Synapse, 40, 1–10.3.0.CO;2-E>CrossRefGoogle ScholarPubMed
McCord, J. (1983). A forty year perspective on effects of child abuse and neglect. Child Abuse & Neglect, 7, 265–270.Google Scholar
McCormack, K., Newman, T. K., Higley, J. D., Maestripieri, D., & Sanchez, M. M. (2009). Serotonin transporter gene variation, infant abuse, and responsiveness to stress in rhesus macaque mothers and infants. Hormones and Behavior, 55, 538–547.Google Scholar
McGloin, J. M., & Widom, C. S. (2002). Resilience among abused and neglected children grown up. Development and Psychopathology, 13, 1021–1038.Google Scholar
Moffitt, T. E. (1993). Adolescence-limited and life course persistent antisocial behavior: A developmental taxonomy. Psychological Review, 100, 674–701.Google Scholar
Moffitt, T. E., Caspi, A., & Rutter, M. (2006). Measured gene–environment interactions in psychopathology: Concepts, research strategies, and implications for research, intervention, and public understanding of genetics. Perspectives on Psychological Science, 1, 5–27.Google Scholar
Moffitt, T. E., Caspi, A., Rutter, M., & Silva, P. A. (2001). Sex differences in antisocial behaviour: Conduct disorder, delinquency, and violence in the Dunedin Longitudinal Study. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Monroe, S. M., & Reid, M. W. (2008). Gene–environment interactions in depression research: Genetic polymorphisms and life-stress procedures. Psychological Science, 19, 947–956.Google Scholar
Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406–425.Google Scholar
Munafò, M. R., Durrant, C., Lewis, G., & Flint, J. (2009). Gene × Environment interactions at the serotonin transporter locus. Biological Psychiatry, 65, 211–219.Google Scholar
Murphy, D. L., Uhl, G. R., Holmes, A., Ren-Patterson, R., Hall, F. S., Sora, I., et al. (2003). Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes, Brain, and Behavior, 2, 350–364.Google Scholar
Nakamura, M., Ueno, S., Sano, A., & Tanabe, H. (2000). The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Molecular Psychiatry, 5, 32–38.Google Scholar
Passamonti, L., Cerasa, A., Gioia, M. C., Magariello, A., Muglia, M., Quattrone, A., et al. (2008). Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. NeuroImage, 40, 1264–1273.Google Scholar
Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462–2471.CrossRefGoogle ScholarPubMed
Rogers, W. (1993). Calculation of quantile regression standard errors. Stata Technical Bulletin, 13, 18–19.Google Scholar
Rubinow, D. R., Schmidt, P. J., & Roca, C. A. (1998). Estrogen–serotonin interactions: Implications for affective regulation. Biological Psychiatry, 44, 839–850.Google Scholar
Russell, S. T., Driscoll, A. K., & Truong, N. (2002). Adolescent same sex romantic attractions and relationships: Implications for substance use and abuse. American Journal of Public Health, 92, 198–202.CrossRefGoogle ScholarPubMed
Scheid, J. M., Holzman, C. B., Jones, N., Friderici, K. H., Nummy, K. A., Symonds, L. L., et al. (2007). Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype. Genes, Brain, and Behavior, 6, 453–464.Google Scholar
Schulz-Heik, R. J., Rhee, S. H., Silvern, L., Lessem, J. M., Haberstick, B. C., Hopfer, C., et al. (2009). Investigation of genetically mediated child effects on maltreatment. Behavioral Genetics, 39, 265–276.CrossRefGoogle Scholar
Sedlak, A. J., & Broadhurst, D. D. (1996). Third National Incidence Study of Child Abuse and Neglect: Final report. Washington, DC: US Department of Health and Human Services.Google Scholar
Sedlak, A. J., Mettenburg, J., Basena, M., Petta, I., McPherson, K., Greene, A., et al. (2010). Fourth National Incidence Study of Child Abuse and Neglect (NIS-4): Report to Congress. Washington, DC: US Department of Health and Human Services.Google Scholar
Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics Part B, 127, 85–89.CrossRefGoogle Scholar
Shin, S. H., Edwards, E. M., & Heeren, T. (2009). Child abuse and neglect: Relations to adolescent binge drinking in the National Longitudinal Study of Adolescent Health (AddHealth) Study. Addictive Behavior, 34, 277–280.Google Scholar
Surtees, P. G., Wainwright, N. W., Willis-Owen, S. A., Luben, R.,Day, N. E., & Flint, J. (2006). Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biological Psychiatry, 59, 224–229.Google Scholar
Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry, 60, 671–676.Google Scholar
Teplin, L. A., Abram, K. M., McClelland, G. M., Dulcan, M. K., & Mericle, A. A. (2002). Psychiatric disorders in youth in juvenile detention. Archives of General Psychiatry, 59, 1133–1143.CrossRefGoogle ScholarPubMed
Tourangeau, R., & Shin, H. (1999). The longitudinal study of adolescent health: Grand sample weight. Chapel Hill, NC: University of North Carolina at Chapel Hill, Carolina Population Center.Google Scholar
Trickett, P. K., & McBride-Chang, C. (1995). The developmental impact of different forms of child abuse and neglect. Developmental Review, 15, 311–337.Google Scholar
Vaske, J., Beaver, K. M., Wright, J. P., Boisvert, D., & Schnupp, R. (2009). An interaction between DAT1 and having an alcoholic father predicts serious alcohol problems in a sample of males. Drug and Alcohol Dependence, 104, 17–22.Google Scholar
Walderhaug, E., Magnusson, A., Neumeister, A., Lappalainen, J., Lunde, H., Refsum, H., et al. (2007). Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biological Psychiatry, 62, 593–599.Google Scholar
Widom, C. S. (1989a). The cycle of violence. Science, 244, 160–166.Google Scholar
Widom, C. S. (1989b). Child abuse, neglect, and violent criminal behavior. Criminology, 27, 251–271.Google Scholar
Widom, C. S., & Ames, M. A. (1994). Criminal consequences of childhood sexual victimization. Child Abuse and Neglect, 18, 303–318.Google Scholar
Widom, C. S., & Brzustowicz, L. M. (2006). MAOA and the “Cycle of violence”: Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry, 60, 684–689.Google Scholar
Widom, C. S., Ireland, T., & Glynn, P. J. (1995). Alcohol abuse in abused and neglected children followed-up: Are they at increased risk? Journal of Studies on Alcohol, 56, 207–217.Google Scholar
Widom, C. S., & Morris, S. (1997). Accuracy of adult recollections of childhood victimization: Part 2. childhood sexual abuse. Psychological Assessment, 9, 34–46.Google Scholar
Widom, C. S., & Shepard, R. L. (1996). Accuracy of adult recollections of childhood victimization: Part 1. Childhood physical abuse. Psychological Assessment, 8, 412–421.Google Scholar
Widom, C. S., White, H. R., Czaja, S. J., & Marmorstein, N. R. (2007). Long-term effects of child abuse and neglect on alcohol use and excessive drinking in middle adulthood. Journal of Studies on Alcohol and Drugs, 68, 317–326.CrossRefGoogle ScholarPubMed
Williams, R. B., Marchuk, D. A., Gadde, K. M., Barefoot, J. C., Grichnik, K., Helms, M. J., et al. (2001). Central nervous system serotonin function and cardiovascular responses to stress. Psychosomatic Medicine, 63, 300–305.Google Scholar
Young, E. A., Korszun, A., Figueiredo, H. F., Banks-Solomon, M., & Herman, J. P. (2007). Sex differences in HPA axis regulation. In Becker, J. B., Berkley, K. J., Geary, N., Hampson, E., Herman, J. P., & Young, E. (Eds.), Sex differences in the brain: From genes to behavior (pp. 95–105). New York: Oxford University Press.Google Scholar
Zhang, T., Parent, C., Weaver, I., & Meaney, M. J. (2004). Maternal programming of individual differences in defensive responses in the rat. Annals of the New York Academy of Sciences, 1032, 85–103.CrossRefGoogle ScholarPubMed