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Hypertensive disorders of pregnancy and the risk of offspring depression in childhood: Findings from the Avon Longitudinal Study of Parents and Children

Published online by Cambridge University Press:  26 July 2019

Berihun Assefa Dachew Open the ORCID record for Berihun Assefa Dachew [Opens in a new window] ,
James G. Scott ,
Kim Betts ,
Abdullah Mamun  and
Rosa Alati
Berihun Assefa Dachew*
Affiliation:
Institute for Social Science Research, The University of Queensland, Brisbane, Australia Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia
James G. Scott
Affiliation:
School of Public Health, Faculty of Medicine, The University of Queensland, Herston, Australia Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Australia Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
Kim Betts
Affiliation:
Institute for Social Science Research, The University of Queensland, Brisbane, Australia Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
Abdullah Mamun
Affiliation:
Institute for Social Science Research, The University of Queensland, Brisbane, Australia
Rosa Alati
Affiliation:
Institute for Social Science Research, The University of Queensland, Brisbane, Australia School of Public Health, Curtin University, Western Australia, Australia
*
Author for correspondence: Berihun Assefa Dachew: Institute for Social Science Research, The University of Queensland, 80 Meiers Road, Brisbane, QLD4068, Australia. Email: [email protected]
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Abstract

Hypertensive disorders of pregnancy (HDP) may increase the risk of offspring depression in childhood. Low birth weight is also associated with increased risk of mental health problems, including depression. This study sought to investigate (a) whether there is an association between HDP and the risk of depression in childhood and (b) whether low birth weight mediates this association. The current study is based on the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective, population-based study that has followed a cohort of offspring since their mothers were pregnant (n = 6,739). Depression at the age of 7 years was diagnosed using parent reports via the Development and Well-Being Assessment (DAWBA). Log-binomial regression and mediation analyses were used. Children exposed to HDP were 2.3 times more likely to have a depression diagnosis compared with nonexposed children, adjusted Risk Ratio [RR], 2.31; 95% CI, [1.20, 4.47]. Low birth weight was a weak mediator of this association. Results were adjusted for confounding variables including antenatal depression and anxiety during pregnancy.This study suggests that fetal exposure to maternal hypertensive disorders of pregnancy increased the risk of childhood depression. The study adds to the evidence suggesting that the uterine environment is a critical determinant of neurodevelopmental and psychiatric outcomes.

Keywords

ALSPACchildhood depressionhypertensive disorders of pregnancyoffspring
Type
Regular Articles
Information
Development and Psychopathology , Volume 32 , Issue 3 , August 2020 , pp. 845 - 851
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Copyright
Copyright © Cambridge University Press 2019

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