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History of child maltreatment and telomere length in immune cell subsets: Associations with stress- and attachment-related hormones

Published online by Cambridge University Press:  14 August 2017

Christina Boeck ,
Sabrina Krause ,
Alexander Karabatsiakis ,
Katharina Schury ,
Harald Gündel ,
Christiane Waller  and
Iris-Tatjana Kolassa
Christina Boeck*
Affiliation:
Ulm University
Sabrina Krause
Affiliation:
University Hospital Ulm
Alexander Karabatsiakis
Affiliation:
Ulm University
Katharina Schury
Affiliation:
Ulm University
Harald Gündel
Affiliation:
University Hospital Ulm
Christiane Waller
Affiliation:
University Hospital Ulm
Iris-Tatjana Kolassa
Affiliation:
Ulm University
*
Address correspondence and reprint requests to: Christina Boeck, Clinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, 89081 Ulm, Germany. E-Mail: [email protected].
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Abstract

Experiencing maltreatment during childhood can have long-lasting consequences for both mental and physical health. Immune cell telomere length (TL) shortening might be one link between child maltreatment (CM) experiences and adverse health outcomes later in life. While the stress hormone cortisol has been associated with TL attrition, the attachment-related hormone oxytocin may promote resilience. In 15 mothers with and 15 age- and body mass index-matched mothers without CM, we assessed TL in peripheral blood mononuclear cells and selected immune cell subsets (monocytes, naive, and memory cytotoxic T cells) by quantitative fluorescence in situ hybridization, as well as peripheral cortisol and oxytocin levels. Memory cytotoxic T cells showed significantly shorter TL in association with CM, whereas TL in monocytes and naive cytotoxic T cells did not significantly differ between the two groups. Across both groups, cortisol was negatively associated with TL, while oxytocin was positively associated with TL in memory cytotoxic T cells. These results indicate that long-lived memory cytotoxic T cells are most affected by the increased biological stress state associated with CM. Keeping in mind the correlational and preliminary nature of the results, the data suggest that cortisol may have a damaging and oxytocin a protective function on TL.

Type
Regular Articles
Information
Development and Psychopathology , Volume 30 , Issue 2 , May 2018 , pp. 539 - 551
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

We thank Traudl Hiller and Dr. Stephanie Dannenmann for technical assistance in the processing of biological samples. As a pilot study for a larger Federal Ministry of Education and Research funded project, this work was funded by university resources of Iris-Tatjana Kolassa. Christina Boeck received a scholarship of the Carl Zeiss Foundation. Katharina Schury received a scholarship of the German Academic Scholarship Foundation (Studienstiftung des Deutschen Volkes).

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