Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-05T04:58:54.078Z Has data issue: false hasContentIssue false

Harsh parent–child conflict is associated with decreased anti-inflammatory gene expression and increased symptom severity in children with asthma

Published online by Cambridge University Press:  04 November 2015

Katherine B. Ehrlich*
Affiliation:
Northwestern University
Gregory E. Miller
Affiliation:
Northwestern University
Edith Chen
Affiliation:
Northwestern University
*
Address correspondence and reprint request to: Katherine B. Ehrlich, Institute for Policy Research, Northwestern University, Evanston, IL 60208; E-mail: [email protected].

Abstract

Asthma is a chronic respiratory disorder that affects over 7 million children in the United States. Evidence indicates that family stressors are associated with worsening of asthma symptoms, and some research suggests that these stressful experiences engender changes in children's immune systems in ways that exacerbate airway inflammation and contribute to both acute and chronic asthma symptoms. We examined the association between observed experiences of parent–child conflict and the expression of signaling molecules involved in the transduction of anti-inflammatory signals that regulate airway inflammation and obstruction. Fifty-seven children and their parents participated in a conflict task, and coders rated interactions for evidence of harsh and supportive behaviors. Children reported on their perceptions of parental support and reported on their daily asthma symptoms for 2 weeks. We collected peripheral blood in children to measure leukocyte expression of messenger RNA for the glucocorticoid receptor and the β2-adrenergic receptor. Analyses revealed that harsh conflict behaviors were associated with decreased expression of both messenger RNAs and more severe asthma symptoms. Neither supportive behaviors nor perceived parental support was associated with gene expression or asthma symptoms. These findings suggest that harsh interactions with parents are associated with downregulation of key anti-inflammatory signaling molecules and difficulties breathing in children with asthma. Children with asthma who are also victims of maltreatment may be particularly susceptible to transcriptional changes in immune cells that could worsen asthma over time.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Achenbach, T. M., McConaughy, S. H., & Howell, C. T. (1987). Child/adolescent behavioral and emotional problems: Implications of cross-informant correlations for situational specificity. Psychological Bulletin, 101, 213232.CrossRefGoogle ScholarPubMed
Bacharier, L. B., Strunk, R. C., Mauger, D., White, D., Lemanske, R. F., & Sorkness, C. A. (2004). Classifying asthma severity in children: Mismatch between symptoms, medication use, and lung function. American Journal of Respiratory and Critical Care Medicine, 170, 426432.CrossRefGoogle ScholarPubMed
Baucom, B. R., Saxbe, D. E., Ramos, M. C., Spies, L. A., Iturralde, E., Duman, S., et al. (2012). Correlates and characteristics of adolescents’ encoded emotional arousal during family conflict. Emotion, 12, 12811291.CrossRefGoogle ScholarPubMed
Bloom, B., Cohen, R. A., & Freeman, G. (2012). Summary health statistics for U.S. children: National Health Interview Survey, 2011 (Vital Health Statistics Series 10) . Washington, DC: US Department of Health and Human Services, National Center for Health Statistics.Google Scholar
Busse, W. W., & Lemanske, R. F. (2001). Asthma. New England Journal of Medicine, 344, 350362.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention. (2009). National Center for Health Statistics: National Hospital Ambulatory Medical Care Survey. Washington, DC: US Department of Health and Human Services, National Center for Health Statistics.Google Scholar
Chen, E., Bloomberg, G. R., Fisher, E. B., & Strunk, R. C. (2003). Predictors of repeat hospitalizations in children with asthma: The role of psychosocial and socioenvironmental factors. Health Psychology, 22, 1218.CrossRefGoogle ScholarPubMed
Chen, E., Hanson, M. D., Paterson, L. Q., Griffin, M. J., Walker, H. A., & Miller, G. E. (2006). Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress. Journal of Allergy and Clinical Immunology, 117, 10141020.CrossRefGoogle ScholarPubMed
Chen, E., & Miller, G. E. (2007). Stress and inflammation in the exacerbation of asthma. Brain, Behavior, and Immunity, 21, 993999.CrossRefGoogle Scholar
Chida, Y., Sudo, N., Sonoda, J., Hiramoto, T., & Kubo, C. (2007). Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus-pituitary-adrenal axis. American Journal of Respiratory and Critical Care Medicine, 175, 316322.CrossRefGoogle ScholarPubMed
Cole, S. W. (2013). Social regulation of human gene expression: Mechanisms and implications for public health. American Journal of Public Health, 103, S84S92.CrossRefGoogle ScholarPubMed
Conn, K. M., Swanson, D., McQuaid, E., Douthit, K., & Fisher, S. G. (2015). The relationship between helplessness and the child's asthma symptoms: The role of social support. Journal of Asthma, 52, 135145.CrossRefGoogle ScholarPubMed
Coogan, P. F., Wise, L. A., O'Connor, G. T., Brown, T. A., Palmer, J. R., & Rosenberg, L. (2013). Abuse during childhood and adolescence and risk of adult-onset asthma in African American women. Journal of Allergy and Clinical Immunology, 131, 10581063.CrossRefGoogle ScholarPubMed
Dishion, T. J., & Kavanagh, K. (1997). FAST: Family Assessment Task. Unpublished manuscript. University of Oregon, Child and Family Center.Google Scholar
Dishion, T. J., & Kavanagh, K. (2003). Intervening in adolescent problem behavior: A family-centered approach. New York: Guilford Press.Google Scholar
Dodge, K. A., & Pettit, G. S. (2003). A biopsychosocial model of the development of chronic conduct problems in adolescence. Developmental Psychology, 39, 349371.CrossRefGoogle ScholarPubMed
Duhig, A. M., & Phares, V. (2009). Positive and negative affect in parents and adolescents: Gender and assessment method considerations. Journal of Psychopathology and Behavioral Assessment, 31, 347357.CrossRefGoogle Scholar
Dykas, M. J., Woodhouse, S. S., Ehrlich, K. B., & Cassidy, J. (2010). Do adolescents and parents reconstruct memories about their conflict as a function of adolescent attachment? Child Development, 81, 14451459.CrossRefGoogle ScholarPubMed
Ehrlich, K. B., Cassidy, J., & Dykas, M. J. (2011). Reporter discrepancies among parents, adolescents, and peers: Adolescent attachment and informant depressive symptoms as explanatory factors. Child Development, 82, 9991012.CrossRefGoogle ScholarPubMed
Ehrlich, K. B., Cassidy, J., Lejuez, C. W., & Daughters, S. B. (2014). Discrepancies about adolescent relationships as a function of informant attachment and depressive symptoms. Journal of Research on Adolescence, 24, 654666.CrossRefGoogle ScholarPubMed
Ehrlich, K. B., Miller, G. M., & Chen, E. (2015). Family functioning, eosinophil activity, and symptoms in children with asthma. Journal of Pediatric Psychology, 40, 781789.CrossRefGoogle ScholarPubMed
Ehrlich, K. B., Richards, J., Cassidy, J., & Lejuez, C. W. (2015). When parents and adolescents disagree about disagreeing: Observed parent-adolescent communication predicts informant discrepancies about conflict. Journal of Research on Adolescence. Advance online publication.Google ScholarPubMed
Forgatch, M., Fetrow, B., & Lathrop, M. (1984). COIMP: Coder Impressions of Videotaped Family Interactions. Unpublished manuscript, Oregon Social Learning Center.Google Scholar
Harter, S. (1982). The Perceived Competence Scale for Children. Child Development, 53, 8797.CrossRefGoogle Scholar
Hofer, M., Sassenberg, K., & Pikowsky, B. (1999). Discourse asymmetries in adolescent daughters’ disputes with mothers. International Journal of Behavioral Development, 23, 10011022.CrossRefGoogle Scholar
Joachim, R. A., Quarcoo, D., Arck, P. C., Herz, U., Renz, H., & Klapp, B. F. (2003). Stress enhances airway reactivity and airway inflammation in an animal model of allergic bronchial asthma. Psychosomatic Medicine, 65, 811815.CrossRefGoogle Scholar
Kaugars, A. S., Klinnert, M. D., & Bender, B. G. (2004). Family influences on pediatric asthma. Journal of Pediatric Psychology, 29, 475491.CrossRefGoogle ScholarPubMed
Kim, H. K., Pears, K. C., Fisher, P. A., Connelly, C. D., & Landsverk, J. A. (2010). Trajectories of maternal harsh parenting in the first 3 years of life. Child Abuse and Neglect, 34, 897906.CrossRefGoogle ScholarPubMed
Klinnert, M. D., Mrazek, P. J., & Mrazek, D. A. (1994). Early asthma onset: The interaction between family stressors and adaptive parenting. Psychiatry, 57, 5161.CrossRefGoogle ScholarPubMed
Klinnert, M. D., Nelson, H. S., Price, M. R., Adinoff, A. D., Leung, D. Y., & Mrazek, D. A. (2001). Onset and persistence of childhood asthma: Predictors from infancy. Pediatrics, 108, E69.CrossRefGoogle ScholarPubMed
Kruschinski, C., Skripuletz, T., Bedoui, S., Raber, K., Straub, R. H., Hoffmann, T., et al. (2008). Postnatal life events affect the severity of asthmatic airway inflammation in the adult rat. Journal of Immunology, 180, 39193925.CrossRefGoogle ScholarPubMed
Lanier, P., Jonson-Reid, M., Stahlschmidt, M. J., Drake, B., & Constantino, J. (2010). Child maltreatment and pediatric health outcomes: A longitudinal study of low-income children. Journal of Pediatric Psychology, 35, 511522.CrossRefGoogle ScholarPubMed
Lansford, J. E., Criss, M. M., Dodge, K. A., Shaw, D. S., Pettit, G. S., & Bates, J. E. (2009). Trajectories of physical discipline: Early childhood antecedents and developmental outcomes. Child Development, 80, 13851402.CrossRefGoogle ScholarPubMed
Miller, G. E., Brody, G. H., Yu, T., & Chen, E. (2014). A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth. Proceedings of the National Academy of Sciences, 111, 1128711292.CrossRefGoogle ScholarPubMed
Miller, G. E., & Chen, E. (2006). Life stress and diminished expression of genes encoding glucocorticoid receptor and β2-adrenergic receptor in children with asthma. Proceedings of the National Academy of Sciences, 103, 54965501.CrossRefGoogle ScholarPubMed
Miller, G. E., Gaudin, A., Zysk, E., & Chen, E. (2009). Parental support and cytokine activity in childhood asthma: The role of glucocorticoid sensitivity. Journal of Allergy and Clinical Immunology, 123, 824830.CrossRefGoogle ScholarPubMed
Murdock, K. K., Adams, S. K., Pears, E., & Ellis, B. (2012). Caregiving load and pediatric asthma morbidity: Conflict matters. Families, Systems, & Health, 30, 101113.CrossRefGoogle ScholarPubMed
Suglia, S. F., Ryan, L., Laden, F., Dockery, D. W., & Wright, R. J. (2008). Violence exposure, a chronic psychosocial stressor, and childhood lung function. Psychosomatic Medicine, 70, 160169.CrossRefGoogle ScholarPubMed
Tobin, E. T., Kane, H. S., Saleh, D. J., Naar-King, S., Poowuttikul, P., Secord, E., et al. (2015). Naturalistically observed conflict and youth asthma symptoms. Health Psychology, 34, 622631.CrossRefGoogle ScholarPubMed
Tobin, E. T., Slatcher, R. B., & Robles, T. F. (2013). Family relationships and physical health: Biological processes and mechanisms. In Newman, M. L. & Roberts, N. A. (Eds.), Health and social relationships: The good, the bad, and the complicated (pp. 145165). Washington, DC: American Psychological Association.Google Scholar
Tomassini, M., Magrini, L., De Petrillo, G., Adriani, E., Bonini, S., Balsano, F., et al. (1996). Serum levels of eosinophil cationic protein in allergic diseases and natural allergen exposure. Journal of Allergy and Clinical Immunology, 97, 13501355.CrossRefGoogle ScholarPubMed
Treutler, C. M., & Epkins, C. C. (2003). Are discrepancies among child, mother, and father reports on children's behavior related to parents’ psychological symptoms and aspects of parent-child relationships? Journal of Abnormal Child Psychology, 31, 1327.CrossRefGoogle ScholarPubMed
Venge, P. (2004). Monitoring the allergic inflammation. Allergy, 59, 2632.CrossRefGoogle ScholarPubMed
Wright, R. J. (2008). Exploring biopsychosocial influences on asthma expression in both the family and community context. American Journal of Respiratory and Critical Care Medicine, 177, 129130.CrossRefGoogle ScholarPubMed
Wright, R. J., Rodriguez, M., & Cohen, S. (1998). Review of psychosocial stress and asthma: An integrated biopsychosocial approach. Thorax, 53, 10661074.CrossRefGoogle ScholarPubMed
Wright, R. J., & Subramanian, S. V. (2007). Advancing a multilevel framework for epidemiologic research on asthma disparities. Chest, 132, 757S769S.CrossRefGoogle ScholarPubMed