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The genetic etiology of childhood depressive symptoms: A developmental perspective

Published online by Cambridge University Press:  04 March 2009

Anita Thapar  and
Peter McGuffin
Anita Thapar*
Affiliation:
Department of Child and Adolescent Psychiatry, University of Manchester, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK
Peter McGuffin
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
*
Anita Thapar, Department of Adolescent and Child Psychiatry, University of Manchester, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HAUK
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Abstract

Although there is some evidence to suggest that depressive symptoms show age-related changes, it remains uncertain as to whether there are also developmental variations in the etiology of depression. In this article, we present findings from a population-based study of twins aged 8 to 16 years with the aim of examining the genetic etiology of depressive symptoms and the effects of age. The results suggest that environmental factors influence the transmission of depressive symptoms in childhood. However depressive symptoms in adolescence appear to be highly heritable. The etiology of depressive symptoms was further explored using factor-derived scores that again suggested the importance of genetic factors in adolescence. However there was some suggestion that genetic influences may contribute to certain types of symptoms (self-deprecation/self-esteem) even in childhood.

Type
Articles
Information
Development and Psychopathology , Volume 8 , Issue 4: Developmental Pathways: Diversity in Process and Outcome , Fall 1996 , pp. 751 - 760
Copyright
Copyright © Cambridge University Press 1996

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References

Andrews, J., Davies, K., Chalmers, I., & Campbell, H. (1986). The Cardiff Births Survey. In Harper, P. S. & Sunderland, E. (Eds.), Genetic and population studies in Wales. Cardiff: University of Wales Press.Google Scholar
Angold, A. (1988a). Childhood and adolescent depression I. Epidemiological and aetiological aspects. British Journal of Psychiatry, 152, 601–617.CrossRefGoogle ScholarPubMed
Angold, A. (1988b). Childhood and adolescent depression II. Research in clinical populations. British Journal of Psychiatry, 153, 476–492.CrossRefGoogle ScholarPubMed
Angold, A., & Rutter, M. (1992). Effects of age and pubertal status on depression in a large clinical sample. Development and Psychopathology, 4, 5–28.CrossRefGoogle Scholar
Angold, A., & Worthman, C. W. (1993). Puberty onset of gender differences in rates of depression: a developmental, epidemiologic and neuroendocrine perspective. Journal of Affective Disorders, 295, 145—158.CrossRefGoogle Scholar
Cicchetti, D., & Schneider-Rosen, K. (1986). An Organizational Approach to Childhood Depression. In Rutter, M., Izard, C. E., & Read, P. B. (Eds.), Depression in Young People: Developmental and Clinical Perspectives (pp. 71–134). New York: Guilford Press.Google Scholar
Cicchetti, D., Rogosch, F. A., & Toth, S. L. (in press). Ontogenesis, Depressotypic Organization and the Depressive Spectrum. In Luthar, S. S., Burack, J., Cicchetti, D., & Weisz, J. (Eds.), Developmental psychopathology: Perspectives on adjustment, risk and disorder. New York: Cambridge University Press.Google Scholar
Cohen, D. J., Dibble, E., Grawe, J. M., & Pollin, W. (1975). Reliably separating identical from fraternal twins. Archives of General Psychiatry, 32, 1371–1375.CrossRefGoogle ScholarPubMed
Cooper, P. J., & Goodyer, I. (1993). A community study of depression in adolescent girls I: Estimates of symptom and syndrome prevalence. British Journal of Psychiatry, 163, 369–374.CrossRefGoogle ScholarPubMed
Costello, E. J., & Angold, A. (1988). Scales to assess child and adolescent depression: checklists, screens and nets. Journal of the American Academy of Child and Adolescent Psychiatry, 27, 726–737.CrossRefGoogle ScholarPubMed
Dwyer, J. T., & DeLong, G. R. (1987). A family history study of 20 probands with childhood manic depressive illness. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 176–180.CrossRefGoogle Scholar
Fishbein, S. (1977). Onset of puberty in MZ and DZ twins. Acta Geneticae Medicae et Gemellologiae, 26, 151–158.CrossRefGoogle Scholar
Fleming, J. E., & Offord, D. R. (1990). Epidemiology of childhood depressive disorders: a critical review. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 571–580.CrossRefGoogle ScholarPubMed
Fleming, J. E., Offord, D. R., & Boyle, M. H. (1989). Prevalence of childhood and adolescent depression: Ontario Child Health Study. British Journal of Psychiatry, 155, 647–654.Google ScholarPubMed
Goodyer, I., & Cooper, P. J. (1993). A community study of depression in adolescent girls II: The clinical features of identified disorder. British Journal of Psychiatry, 163, 374–380.CrossRefGoogle ScholarPubMed
Harrington, R. (1994). Affective disorders. In Rutter, M., Taylor, E. & Hersov, L. (Eds.), Child and Adolescent Psychiatry. Modern approaches, 3rd ed. (pp. 330–350). London: Blackwell Scientific.Google Scholar
Harrington, R., Fudge, H., Rutter, M., Pickles, A., & Hill, J. (1990). Adult outcomes of childhood and adolescent depression I. Psychiatric status. Archives of General Psychiatry, 47, 465–473.CrossRefGoogle ScholarPubMed
Harrington, R., Fudge, H., Rutter, M., Bredenkamp, D., Groothues, C., & Pridham, J. (1993). Child and adult depression: A test of continuities with data from a family study. British Journal of Psychiatry, 162, 627–633.CrossRefGoogle ScholarPubMed
Harrington, R., Rutter, M., Weissman, M. M., Fudge, H., Groothues, C., Bredenkamp, D., Pickles, A., Rende, R., & Wickramaratne, P. (1996). Psychiatric disorders in the relatives of depressed probands. I. Comparison of prepubertal, adolescent and early adult onset cases. Manuscript submitted for publication.Google Scholar
Horwarth, E., Johnson, J., Klerman, G. L., & Weissman, M. M. (1992). Depressive symptoms as relative and attributable risk factors for first onset major depression. Archives of General Psychiatry, 49, 817–823.CrossRefGoogle Scholar
Johnson, J., Weissman, M. M., & Klerman, G. L. (1992). Service utilization and social morbidity associated with depressive symptoms in the community. Journal of the American Medical Association, 267, 1478–1483.CrossRefGoogle ScholarPubMed
Kashani, J., Beck, N. C., Hoeper, E. W., Fallahi, C., Corcoran, C. M., McAllister, J. A., Rosenberg, T. K., & Reid, J. C. (1987). Psychiatric disorders in a community sample of adolescents. American Journal of Psychiatry, 144, 584–589.Google Scholar
Kolvin, I., Barrett, M. L., Bhate, S. R., Berney, T. P., Famuyiwa, O. O., Fundudis, T., & Tyrer, S. (1991). The Newcastle Child Depression Project. Diagnosis and Classification of Depression. British Journal of Psychiatry (supplement) 159, 9–21.CrossRefGoogle Scholar
Kovacs, M., Aksikal, H. S., Gatsonis, C., & Parrone, P. L. (1994). Childhood-onset dysthymic disorder. Archives of General Psychiatry, 51, 365–374.CrossRefGoogle ScholarPubMed
Kutcher, S., & Marton, P. (1991). Affective disorders in first degree relatives of adolescent onset bipolars, uni-polars and normal controls. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 75–78.CrossRefGoogle ScholarPubMed
Lewinsohn, P. M., Clarke, G. N., Seeley, J. R., & Rohde, P. (1994). Major depression in community adolescents: Age at onset, episode duration, and time to recurrence. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 809–818.CrossRefGoogle ScholarPubMed
Loehlin, J. C., & Nichols, R. C. (1976). Heredity, environment and personality. Austin: University of Texas Press.Google Scholar
McGee, R., Feehan, M., Williams, S., Partridge, F., Silva, P. A., & Kelly, J. (1990). DSM-III disorders in a large sample of adolescents. Journal of the American Academy of Chid and Adolescent Psychiatry, 29, 611–619.CrossRefGoogle Scholar
McGee, R., Feehan, M., Williams, S., & Anderson, J. (1992). DSM-III disorders from age 11 to age 15 years. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 50–59.CrossRefGoogle ScholarPubMed
McGuffin, P., Owen, M. J., O'Donovan, M. C., Thapar, A., & Gottesman, I. I. (1994). Seminars in psychiatric genetics. London: Gaskell.Google Scholar
McGuire, S., Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. (1994). Genetic and environmental influences on perceptions of self-worth and competence in adolescence: A study of twins, full siblings and step-siblings. Child Development, 65, 785–799.CrossRefGoogle ScholarPubMed
Meyer, J., Eaves, L., Heath, A., & Martin, N. G. (1991). Estimating genetic influences on the age-at-menarche: A survival analysis approach. American Journal of Medical Genetics, 39, 148–154.CrossRefGoogle ScholarPubMed
Neale, M. C. (1991). Mx. Statistical Modeling. Richmond, VA: Department of Human Genetics, MCV.Google Scholar
Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic.CrossRefGoogle Scholar
Nichols, R. C., & Bilbro, W. C. (1966). The diagnosis of twin zygosity. Acta Genetica, Basel, 16, 265–275.Google ScholarPubMed
Orvaschel, H., Walsh-Allis, G., & Ye, W. (1988). Psy-chopathology in children of parents with recurrent depression. Journal of Abnormal Child Psychology, 16, 17–28.CrossRefGoogle Scholar
Orvaschel, H. (1990). Early onset psychiatric disorder in high risk children and increased familial morbidity. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 184–188.CrossRefGoogle ScholarPubMed
Plomin, R., & Rende, R. (1991). Human behavioral genetics. Annual Review of Psychology, 42, 161–190.CrossRefGoogle ScholarPubMed
Plomin, R. (1994). Genetics and experience. Vie interplay between nature and nurture. Thousand Oaks, CA: Sage.Google Scholar
Puig-Antich, J., Goetz, D., Davies, M., Kaplan, T., Davies, S., Ostrow, L., Asnis, L., Twomey, J., Iyengar, S., & Ryan, N. D. (1989). A controlled family history study of prepubertal major depressive disorder. Archives of General Psychiatry, 46, 406–418.CrossRefGoogle ScholarPubMed
Rice, J., Rochberg, N., Endicott, J., Lavori, P. W., & Miller, C. (1992). Stability of psychiatric diagnoses: An application to the affective disorders. Archives of General Psychiatry, 49, 824–830.CrossRefGoogle Scholar
Rutter, M., Tizard, J., & Whitmore, K. (1970). Education, health and behaviour. London: Longman.Google Scholar
Rutter, M. (1986). The developmental psychopathology of depression: Issues and perspectives. In Rutter, M., Izard, C., & Read, P. (Eds.), Depression in young people: Developmental and clinical perspectives (pp. 330). New York: Guilford Press.Google Scholar
Rutter, M., Graham, P., Chadwick, O. F., & Yule, W. (1976). Adolescent turmoil: Fact or fiction? Journal of Child Psychology and Psychiatry, 17, 35–56.CrossRefGoogle ScholarPubMed
Ryan, N. D., Puig-Antich, J., Ambrosini, P., Rabinovich, H., Robinson, D., Nelson, B., Iyengar, S., & Twomey, J. (1987). The clinical picture of major depression in children and adolescents. Archives of General Psychiatry, 44, 854–861.CrossRefGoogle ScholarPubMed
Scarr, S., & McCartney, K. (1983). How people make their own environments: A theory of genotype environment effects. Child Development, 54, 424–435.Google Scholar
Strober, M. (1992). Relevance of early age-of-onset in genetic studies of bipolar affective disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 606–610.CrossRefGoogle ScholarPubMed
Strober, M., Morrell, W., Burroughs, J., Lampert, C., Danforth, H., & Freeman, R. (1988). A family study of bipolar I disorder in adolescence. Journal of Affective Disorders, 15, 255–268.CrossRefGoogle ScholarPubMed
Thapar, A. (1995). A twin study of psychiatric symptoms in childhood. PhD thesis, University of Wales College of Medicine.Google Scholar
Thapar, A., & McGuffin, P. (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry, 165, 259–265.CrossRefGoogle ScholarPubMed
Thapar, A., & McGuffin, P. (1995a). Are anxiety symptoms in childhood heritable? Journal of Child Psychology and Psychiatry, 36, 439–447.CrossRefGoogle ScholarPubMed
Thapar, A., Hervas, A., & McGuffin, P. (1995b). Childhood hyperactivity scores are highly heritable and show sibling competition effects: Twin study evidence. Behavior Genetics, 25, 537–544.CrossRefGoogle ScholarPubMed
Weiss, B., Weisz, J., Politano, M., Carey, M., Nelson, W., & Finch, A. (1992). Relations among self-reported depressive symptoms in clinic-referred children vs adolescents. Journal of Abnormal Psychology, 101, 391–397.CrossRefGoogle Scholar
Weissman, M. M., Leckman, J. F., Merikangas, K. R., Gammon, D., & Prusoff, B. A. (1984a). Depression and anxiety disorders in parents and children. Archives of General Psychiatry, 41, 845–852.CrossRefGoogle ScholarPubMed
Weissman, M. M., Wickramaratne, P., Merikangas, K. R., Leckman, J. F., Prusoff, B. A., Caruso, K. A., Kidd, K. K., & Gammon, D. (1984b). Onset of major depression in early adulthood. Increased familial loading and specificity. Archives of General Psychiatry, 41, 1136–1143.CrossRefGoogle ScholarPubMed
Weissman, M. M., Gammon, D., John, K., Merikangas, K. R., Warner, V., Prusoff, B. A., & Sholomskas, D. (1987). Children of depressed parents. Increased psy-chopathology and early onset of major depression. Archives of General Psychiatry, 44, 847–853.CrossRefGoogle Scholar
Weissman, M. M., Fendrich, M., Warner, V., & Wickramaratne, P. (1992). Incidence of psychiatric disorder in offspring at high and low risk for depression. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 640–648.CrossRefGoogle ScholarPubMed
Wood, A., Kroll, L., Moore, A., & Harrington, R. C. (1995). Properties of the Mood and Feelings Questionnaire in adolescent psychiatric outpatients: A research note. Journal of Child Psychology and Psychiatry, 36, 327–334.CrossRefGoogle ScholarPubMed