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Gene–environment correlation in the development of adolescent substance abuse: Selection effects of child personality and mediation via contextual risk factors

Published online by Cambridge University Press:  11 February 2013

Brian M. Hicks ,
Wendy Johnson ,
C. Emily Durbin ,
Daniel M. Blonigen ,
William G. Iacono  and
Matt McGue
Brian M. Hicks*
Affiliation:
University of Michigan
Wendy Johnson
Affiliation:
University of Edinburgh
C. Emily Durbin
Affiliation:
Michigan State University
Daniel M. Blonigen
Affiliation:
Palo Alto Health Care System
William G. Iacono
Affiliation:
University of Minnesota
Matt McGue
Affiliation:
University of Minnesota
*
Address correspondence and reprint requests to: Brian M. Hicks, Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109; E-mail: [email protected].
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Abstract

We used a longitudinal twin design to examine selection effects of personality traits at age 11 on high-risk environmental contexts at age 14 and the extent to which these contexts mediated risk for substance abuse at age 17. Socialization at age 11 (willingness to follow rules and endorse conventional values) predicted exposure to contextual risk at age 14. Contextual risk partially mediated the effect of socialization on substance abuse, though socialization also had a direct effect. In contrast, boldness at age 11 (social engagement and assurance, thrill seeking, and stress resilience) also predicted substance abuse directly but was unrelated to contextual risk. There was substantial overlap in the genetic and shared environmental influences on socialization and contextual risk, and genetic risk in socialization contributed to substance abuse indirectly via increased exposure to contextual risk. This suggests that active gene–environment correlations related to individual differences in socialization contributed to an early, high-risk developmental trajectory for adolescent substance abuse. In contrast, boldness appeared to index an independent and direct genetic risk factor for adolescent substance abuse.

Type
Special Section Articles
Information
Development and Psychopathology , Volume 25 , Issue 1: Gene–Environment Correlation in Developmental Psychopathology , February 2013 , pp. 119 - 132
Copyright
Copyright © Cambridge University Press 2013

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References

Appleyard, K., Egeland, B., van Dulmen, M. H. M., & Sroufe, L. A. (2005). When more is not better: The role of cumulative risk in child behavior outcomes. Journal of Child Psychology and Psychiatry, 46, 235–245.Google Scholar
Armstrong, T. D., & Costello, E. J. (2002). Community studies on adolescent substance use, abuse, or dependence and psychiatric comorbidity. Journal of Consulting and Clinical Psychology, 70, 1224–1239.Google Scholar
Baron, R. M., & Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182.Google Scholar
Bemmels, H. R., Burt, S. A., Legrand, L. N., Iacono, W. G., & McGue, M. (2008). The heritability of life events: An adolescent twin and adoption study. Twin Research and Human Genetics, 11, 257–265.Google Scholar
Blonigen, D. M., Carlson, M. D., Hicks, B. M., Krueger, R. F., & Iacono, W. G. (2008). Stability and change in personality traits from late adolescence to early adulthood: A longitudinal twin study. Journal of Personality, 76, 229–266.Google Scholar
Blonigen, D. M., Hicks, B. M., Krueger, R. F., Patrick, C. J., & Iacono, W. G. (2006). Continuity and change in psychopathic personality traits as measured via normal range personality: A longitudinal-biometric study. Journal of Abnormal Psychology, 115, 85–95.Google Scholar
Burt, S. A., Krueger, R. F., McGue, M., & Iacono, W. G. (2003). Parent–child conflict and the comorbidity among childhood externalizing disorders. Archives of General Psychiatry, 60, 505–513.Google Scholar
Buu, A., DiPiazza, C., Wang, J., Puttler, L. I., Fitzgerald, H. E., & Zucker, R. A. (2009). Parent, family, and neighborhood effects on the development of child substance use and other psychopathology from preschool to the start of adulthood. Journal of Studies of Alcohol and Drugs, 70, 489–498.Google Scholar
Chassin, L., Pitts, S. C., DeLucia, C., & Todd, M. (1999). A longitudinal study of children of alcoholics: Predicting young adult substance use disorders, anxiety, and depression. Journal of Abnormal Psychology, 108, 106–119.Google Scholar
Clark, D. B., Kirisci, L., & Tarter, R. E. (1998). Adolescent versus adult onset and the development of substance use disorder in males. Drug and Alcohol Dependence, 49, 115–121.Google Scholar
Cohen, J., & Cohen, P. (1983). Applied multiple regression/correlation analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum.Google Scholar
Cukrowicz, K. C., Taylor, J., Schatschneider, C., & Iacono, W. G. (2006). Personality differences in children and adolescents with attention deficit/hyperactivity disorder, conduct disorder, and controls. Journal of Child Psychology and Psychiatry, 47, 151–159.Google Scholar
Deater-Deckard, K., Dodge, K. A., Bates, J. E., & Pettit, G. S. (1998). Multiple risk factors in the development of externalizing behavior problems: Group and individual differences. Development and Psychopathology, 10, 469–493.Google Scholar
Eisenberg, N., Zhou, Q., Spinrad, T. L., Valiente, C., Fabes, R. A., & Liew, J. (2005). Relations among positive parenting, children's effortful control, and externalizing problems: A three-wave longitudinal study. Child Development, 76, 1055–1071.Google Scholar
Elkins, I. J., McGue, M., & Iacono, W. G. (1997). Genetic and environmental influences on parent–son relationships: Evidence for increasing genetic influence during adolescence. Developmental Psychology, 33, 351–363.Google Scholar
Fox, N. A., Henderson, H. A., Marshall, P. J., Nichols, K. E., & Ghera, M. M. (2005). Behavioral inhibition: Linking biology and behavior within a developmental framework. Annual Review of Psychology, 56, 235–262.Google Scholar
Granic, I., & Patterson, G. R. (2006). Toward a comprehensive model of antisocial development: A dynamic systems approach. Psychological Review, 113, 101–131.Google Scholar
Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychological Bulletin, 112, 64–105.Google Scholar
Hicks, B. M., Iacono, W. G., & McGue, M. (2010). Consequences of an adolescent onset and persistent course of alcohol dependence in men: Adolescent risk factors and adult outcomes. Alcoholism: Clinical & Experimental Research, 34, 819–833.CrossRefGoogle ScholarPubMed
Hicks, B. M., Iacono, W. G., & McGue, M. (2012). Identifying childhood characteristics that underlie pre-morbid risk for substance use disorders: Socialization and boldness. Manuscript submitted for publication.Google Scholar
Hicks, B. M., Johnson, W., Durbin, C. E., Blonigen, D. M., Iacono, W. G., & McGue, M. (2012). Selection and mediation effects between child personality and multiple environmental risk factors in the development of adolescent substance abuse. Manuscript submitted for publication.Google Scholar
Hicks, B. M., South, S. C., DiRago, A. C., Iacono, W. G., & McGue, M. (2009). Environmental adversity and increasing genetic risk for externalizing disorders. Archives of General Psychiatry, 66, 640–648.CrossRefGoogle ScholarPubMed
Hussong, A. M., Jones, D. J., Stein, G. L., Baucom, D. H., & Boeding, S. (2011). An internalizing pathway to alcohol use and disorder. Psychology of Addictive Behaviors, 25, 390–404.Google Scholar
Iacono, W. G., Carlson, S. R., Taylor, J., Elkins, I. J., & McGue, M. (1999). Behavioral disinhibition and the development of substance use disorders: Findings from the Minnesota Twin Family Study. Development and Psychopathology, 11, 869–900.Google Scholar
Iacono, W. G., Malone, S. M., & McGue, M. (2008). Behavioral disinhibition and the development of early onset addiction: Common and specific influences. Annual Review of Clinical Psychology, 4, 12.1–12.24.CrossRefGoogle ScholarPubMed
Jessor, R., & Jessor, S. L. (1977). Problem behavior and psychosocial development: A longitudinal study of youth. New York: Academic Press.Google Scholar
Johnson, W., McGue, M., & Iacono, W. G. (2005). Disruptive behavior and school grades: Genetic and environmental relations in 11-year-olds. Journal of Educational Psychology, 97, 391–405.CrossRefGoogle Scholar
Kagan, J. (1994). Galen's prophecy: Temperament in human nature. New York: Basic Books.Google Scholar
Kaplow, J. B., Curran, P. J., Angold, A., & Costello, E. J. (2001). The prospective relation between dimensions of anxiety and the initiation of adolescent alcohol use. Journal of Clinical Child Psychology, 30, 316–326.Google Scholar
Keyes, M. A., Iacono, W. G., & McGue, M. (2007). Early onset problem behavior, young adult psychopathology, and contextual risk. Twin Research and Human Genetics, 10, 45–53.Google Scholar
Keyes, M. A., Malone, S. M., Elkins, I. J., Legrand, L. N., McGue, M., & Iacono, W. G. (2009). The enrichment study of the Minnesota Twin Family Study: Increasing the yield of twin families at high risk for externalizing psychopathology. Twin Research and Human Genetics, 12, 489–501.Google Scholar
King, S. M., Iacono, W. G., & McGue, M. (2004). Childhood externalizing and internalizing psychopathology in the prediction of early substance use. Addiction, 99, 1548–1559.Google Scholar
Kochanska, G., Friesenborg, A. E., Lange, L. A., & Martel, M. M. (2004). Parents' personality and infants' temperament as contributors to their emerging relationship. Journal of Personality and Social Psychology, 86, 744–759.Google Scholar
Krueger, R. F., Caspi, A., Moffitt, T. E., Silva, P. A., & McGee, R. (1996). Personality traits are differentially linked to mental disorders: A multitrait–multidiagnosis study of an adolescent birth cohort. Journal of Abnormal Psychology, 105, 299–312.Google Scholar
McGue, M., Iacono, W. G., & Krueger, R. F. (2006). The association of earl adolescent problem behavior and adult psychopathology: A multivariate behavioral genetic perspective. Behavior Genetics, 36, 591–602.Google Scholar
Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: A developmental taxonomy. Psychological Review, 100, 674–701.Google Scholar
Moffitt, T. E., Caspi, A., Rutter, M., & Silva, P. A. (2001). Sex differences in antisocial behavior: Conduct disorder, delinquency, and violence in the Dunedin Longitudinal Study. Cambridge: Cambridge University Press.Google Scholar
Muthén, L. K., & Muthén, B. O. (2007). Mplus user's guide (5th ed.) Los Angles: Author.Google Scholar
Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2004). Mx: Statistical modeling (6th ed. rev.). Richmond, VA: Virginia Commonwealth University, Department of Psychiatry.Google Scholar
Patrick, C. J., Fowles, D. C., & Krueger, R. F. (2009). Triarchic conceptualization of psychopathy: Developmental origins of disinhibition, boldness, and meanness. Development and Psychopathology, 21, 913–938.Google Scholar
Patterson, G. R., DeBaryshe, B. D., & Ramsey, E. (1989). A developmental perspective on antisocial behavior. American Psychologist, 44, 329–335.Google Scholar
Plomin, R., & Bergeman, C. S. (1991). The nature of nurture: Genetic influence on environmental measures. Behavioral and Brain Sciences, 14, 373–385.Google Scholar
Prinzie, P., Stams, G. J. J. M., Dekovic, M., & Reijntjes, A. H. A. (2009). The relations between parents' Big Five personality factors and parenting: A meta-analytic review. Journal of Personality and Social Psychology, 97, 351–362.Google Scholar
Purcell, S. (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research, 5, 554–571.CrossRefGoogle ScholarPubMed
Roberts, B. W., Caspi, A., & Moffitt, T. E. (2001). The kids are alright: Growth and stability in personality development from adolescence to adulthood. Journal of Personality and Social Psychology, 81, 670–683.Google Scholar
Roberts, B. W., & DelVecchio, W. F. (2000). The rank-order stability of personality traits from childhood to old age: A quantitative review of longitudinal studies. Psychological Bulletin, 126, 3–25.Google Scholar
Roberts, B. W., Walton, K. E., & Viechtbauer, W. (2006). Patterns of mean-level change in personality traits across the life course: A meta-analysis of longitudinal studies. Psychological Bulletin, 132, 1–25.Google Scholar
Robins, L. M., Babor, T., & Cottler, L. B. (1987). Composite International Diagnostic Interview: Expanded substance abuse module. St. Louis, MO: Authors.Google Scholar
Rutter, M., Caspi, A., & Moffitt, T. E. (2003). Using sex differences in psychopathology to study causal mechanisms: Unifying issues and research strategies. Journal of Child Psychology and Psychiatry and Allied Disciplines, 44, 1092–1115.Google Scholar
Scarr, S., & McCartney, K. (1983). How people make their own environments: A theory of genotype greater then environment effects. Child Development, 54, 424–435.Google Scholar
Shedler, J., & Block, J. (1990). Adolescent drug use and psychological health: A longitudinal inquiry. American Psychologist, 45, 612–630.CrossRefGoogle ScholarPubMed
Sher, K. J., Grekin, E. R., & Williams, N. A. (2005). The development of alcohol use disorders. Annual Review of Clinical Psychology, 1, 493–523.Google Scholar
Taylor, J., McGue, M., Iacono, W. G., & Lykken, D. T. (2000). A behavioral genetic analysis of the relationship between the socialization scale and self-reported delinquency. Journal of Personality, 68, 29–50.Google Scholar
Thomas, A., & Chess, S. (1977). Temperament and development. New York: Brunner/Mazel.Google Scholar
Vaidyanathan, U., Hall, J. R., Patrick, C. J., & Bernat, E. M. (2011). Clarifying the role of defensive reactivity in psychopathy and antisocial personality using startle reflex methodology. Journal of Abnormal Psychology, 120, 253–258.Google Scholar
Wade, T. D., & Kendler, K. S. (2000). The genetic epidemiology of parental discipline. Psychological Medicine, 30, 1303–1313.Google Scholar
Walden, B., McGue, M., Iacono, W. G., Burt, S. A., & Elkins, I. (2004). Identifying shared environmental contributions to early substance use: The respective roles of peers and parents. Journal of Abnormal Psychology, 113, 440–450.CrossRefGoogle ScholarPubMed
Welner, Z., Reich, W., Herjanic, B., Jung, K., & Amado, H. (1987). Reliability, validity, and parent–child agreement studies of the Diagnostic Interview for Children and Adolescents (DICA). Journal of the Academy of Child & Adolescent Psychiatry, 26, 649–653.Google Scholar
World Health Organization. (2008). WHO report on the global tobacco epidemic, 2008: The MPOWER package. Geneva: Author.Google Scholar
World Health Organization. (2011). Global status report on alcohol and health. Geneva: Author.Google Scholar
Zucker, R. A. (2006). Alcohol use and the alcohol use disorders: A developmental biopsychosocial systems formulation covering the life course. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology: Vol. 3. Risk, disorder, and adaption (2nd ed., pp. 620–656). Hoboken, NJ: Wiley.Google Scholar
Zucker, R. A., Chermack, S. T., & Curran, G. M. (2000). Alcoholism: A life span perspective on etiology and course. In Sameroff, A., Lewis, M., & Miller, S. (Eds.), Handbook of developmental psychopathology (2nd ed., pp. 569–587). New York: Plenum Press.Google Scholar
Zucker, R. A., Donovan, J. E., Masten, A. S., Mattson, M. E., & Moss, H. B. (2008). Early developmental processes and the continuity of risk for underage drinking and problem drinking. Pediatrics, 121 (Suppl. 4), S252–S272.CrossRefGoogle ScholarPubMed
Zucker, R. A., & Gomberg, E. S. L. (1986). Etiology of alcoholism reconsidered: The case for a biopsychosocial process. American Psychologist, 41, 783–793.Google Scholar