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The future of genomics for developmentalists

Published online by Cambridge University Press:  17 December 2013

Robert Plomin  and
Michael A. Simpson
Robert Plomin*
Affiliation:
King's College London
Michael A. Simpson
Affiliation:
King's College London
*
Address correspondence and reprint requests to: Robert Plomin, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK; E-mail: [email protected].
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Abstract

The momentum of genomic science will carry it far into the future and into the heart of research on typical and atypical behavioral development. The purpose of this paper is to focus on a few implications and applications of these advances for understanding behavioral development. Quantitative genetics is genomic and will chart the course for molecular genomic research now that these two worlds of genetics are merging in the search for many genes of small effect. Although current attempts to identify specific genes have had limited success, known as the missing heritability problem, whole-genome sequencing will improve this situation by identifying all DNA sequence variations, including rare variants. Because the heritability of complex traits is caused by many DNA variants of small effect in the population, polygenic scores that are composites of hundreds or thousands of DNA variants will be used by developmentalists to predict children's genetic risk and resilience. The most far-reaching advance will be the widespread availability of whole-genome sequence for children, which means that developmentalists would no longer need to obtain DNA or to genotype children in order to use genomic information in research or in the clinic.

Type
Regular Articles
Information
Development and Psychopathology , Volume 25 , Issue 4pt2: Development and Psychopathology: A Vision Realized , November 2013 , pp. 1263 - 1278
Copyright
Copyright © Cambridge University Press 2013 

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