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Diagnostic and measurement issues in the assessment of pediatric bipolar disorder: Implications for understanding mood disorder across the life cycle

Published online by Cambridge University Press:  25 October 2006

ERIC YOUNGSTROM ,
OREN MEYERS ,
JENNIFER KOGOS YOUNGSTROM ,
JOSEPH R. CALABRESE  and
ROBERT L. FINDLING
ERIC YOUNGSTROM
Affiliation:
University of North Carolina, Chapel Hill
OREN MEYERS
Affiliation:
Case Western Reserve University Applewood Centers, Incorporated
JENNIFER KOGOS YOUNGSTROM
Affiliation:
University of North Carolina, Chapel Hill Applewood Centers, Incorporated
JOSEPH R. CALABRESE
Affiliation:
Case Western Reserve University
ROBERT L. FINDLING
Affiliation:
Case Western Reserve University
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Abstract

The goal of this paper is to review assessment research of bipolar disorder in children and adolescents. The review addresses numerous themes: the benefits and costs of involving clinical judgment in the diagnostic process, particularly with regard to diagnosis and mood severity ratings; the validity of parent, teacher, and youth self-report of manic symptoms; how much cross-situational consistency is typically shown in mood and behavior; the extent to which a parent's mental health status influences their report of child behavior; how different measures compare in terms of detecting bipolar disorder, the challenges in comparing the performance of measures across research groups, and the leading candidates for research or clinical use; evidence-based strategies for interpreting measures as diagnostic aids; how test performance changes when a test is used in a new setting and what implications this has for research samples as well as clinical practice; the role of family history of mood disorder within an assessment framework; and the implications of assessment research for the understanding of phenomenology of bipolar disorder from a developmental framework.We thank the families who participated in this program of research. This work was supported in part by NIMH R01 MH066647, as well as a Center Grant from the Stanley Medical Research Institute.

Type
Research Article
Information
Development and Psychopathology , Volume 18 , Issue 4 , December 2006 , pp. 989 - 1021
Copyright
© 2006 Cambridge University Press

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References

REFERENCES

Achenbach, T. M. (1991a). Manual for the Child Behavior Checklist/4–18 and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M. (1991b). Manual for the Teacher's Report Form and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M. (1991c). Manual for the Youth Self-Report Form and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M., McConaughy, S. H., & Howell, C. T. (1987). Child/adolescent behavioral and emotional problems: Implication of cross-informant correlations for situational specificity. Psychological Bulletin, 101, 213–232.Google Scholar
Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA School-Age Forms and Profiles. Burlington, VT: University of Vermont.
Akiskal, H. S., & Pinto, O. (1999). The evolving bipolar spectrum. Prototypes I, II, III, and IV. Psychiatric Clinics of North America, 22, 517–534.Google Scholar
Altman, E. (1998). Rating scales for mania: Is self-rating reliable? Journal of Affective Disorders, 50, 283–286.Google Scholar
American Psychiatric Association. (2001). Diagnostic and statistical manual of mental disorders (4th ed., Text Revision). Washington, DC: Author.
Anastasi, A., & Urbina, S. (1997). Psychological testing (7th ed.). New York: Macmillan.
Andershed, H. A., Gustafson, S. B., Kerr, M., & Stattin, H. (2002). The usefulness of self-reported psychopathy-like traits in the study of antisocial behaviour among non-referred adolescents. European Journal of Personality, 16, 383–402.Google Scholar
Andreasen, N. C., Endicott, J., Spitzer, R. L., & Winokur, G. (1977). The family history method using diagnostic criteria. Reliability and validity. Archives of General Psychiatry, 34, 1229–1235.Google Scholar
Angst, J., Gamma, A., Benazzi, F., Ajdacic, V., Eich, D., & Rossler, W. (2003). Toward a re-definition of subthreshold bipolarity: Epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. Journal of Affective Disorders, 73, 133–146.Google Scholar
Axelson, D., Birmaher, B. J., Brent, D., Wassick, S., Hoover, C., Bridge, J., et al. (2003). A preliminary study of the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children mania rating scale for children and adolescents. Journal of Child and Adolescent Psychopharmacology, 13, 463–470.Google Scholar
Baldessarini, R. J., Finklestein, S., & Arana, G. W. (1983). The predictive power of diagnostic tests and the effect of prevalence of illness. Archives of General Psychiatry, 40, 569–573.Google Scholar
Bauer, M. S., Crits-Christoph, P., Ball, W. A., Dewees, E., McAllister, T., Alahi, P., et al. (1991). Independent assessment of manic and depressive symptoms by self-rating. Scale characteristics and implications for the study of mania. Archives of General Psychiatry, 48, 807–812.Google Scholar
Benazzi, F., & Akiskal, H. S. (2005). A downscaled practical measure of mood lability as a screening tool for bipolar II. Journal of Affective Disorders, 84, 225–232.Google Scholar
Bhatnagar, K., Youngstrom, E. A., Williams, F., Duax, J., Calabrese, J. R., & Findling, R. L. (2006). The effects of ethnicity on diagnostic rates of bipolar spectrum disorder and manic symptom expression in youth ages 5–17 years. Manuscript submitted for publication.
Biederman, J., Klein, R. G., Pine, D. S., & Klein, D. F. (1998). Resolved: Mania is mistaken for ADHD in prepubertal children. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 1091–1093.Google Scholar
Biederman, J., Wozniak, J., Kiely, K., Ablon, S., Faraone, S., Mick, E., et al. (1995). CBCL clinical scales discriminate prepubertal children with structured interview-derived diagnosis of mania from those with ADHD. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 464–471.Google Scholar
Birmaher, B., Axelson, D., Strober, M., Gill, M. K., Valeri, S., Chiappetta, L., et al. (in press). Clinical course of children and adolescents with bipolar spectrum disorders. Archives of General Psychiatry.
Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., et al. (2003). Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD initiative. British Medical Journal, 326, 41–44.Google Scholar
Bowring, M. A., & Kovacs, M. (1992). Difficulties in diagnosing manic disorders among children and adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 31, 611–614.Google Scholar
Campbell, D. T., & Kenny, D. A. (1999). A primer on regression artifacts. New York: Guilford Press.
Carlson, G. A. (2002). Bipolar disorder in children and adolescents: A critical review. In D. Shaffer & B. Waslick (Eds.), The many faces of depression in children and adolescents (Vol. 21, pp. 105–128). Washington, DC: American Psychiatric Association.
Carlson, G. A. (2005). Early onset bipolar disorder: Clinical and research considerations. Journal of Clinical Child and Adolescent Psychology, 34, 333–343.Google Scholar
Carlson, G. A., Loney, J., Salisbury, H., & Volpe, R. J. (1998). Young referred boys with DICA-P manic symptoms vs. two comparison groups. Journal of Affective Disorders, 121, 113–121.Google Scholar
Carlson, G. A., & Strober, M. (1978). Manic–depressive illness in early adolescence. A study of clinical and diagnostic characteristics in six cases. Journal of the American Academy of Child & Adolescent Psychiatry, 17, 138–153.Google Scholar
Carlson, G. A., & Youngstrom, E. A. (2003). Clinical implications of pervasive manic symptoms in children. Biological Psychiatry, 53, 1050–1058.Google Scholar
Cicchetti, D., Rogosch, F. A., & Toth, S. L. (1994). A developmental psychopathology perspective on depression in children and adolescents. In W. M. Reynolds & H. F. Johnston (Eds.), Handbook of depression in children and adolescents (pp. 123–142). New York: Plenum Press.
Cohen, J. (1983). The cost of dichotomization. Applied Psychological Measurement, 7, 249–253.Google Scholar
Costello, E. J., Angold, A., Burns, B. J., Stangl, D. K., Tweed, D. L., Erkanli, A., et al. (1996). The Great Smoky Mountains Study of youth: Goals, design, methods, and the prevalence of DSM-III-R disorders. Archives of General Psychiatry, 53, 1129–1136.Google Scholar
Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837–844.Google Scholar
Danielson, C. K., Youngstrom, E. A., Findling, R. L., & Calabrese, J. R. (2003). Discriminative validity of the General Behavior Inventory using youth report. Journal of Abnormal Child Psychology, 31, 29–39.Google Scholar
Davis, R. E. (1979). Manic-depressive variant syndrome of childhood: A preliminary report. The American Journal of Psychiatry, 136, 702–706.Google Scholar
DelBello, M. O., Soutullo, C. A., & Strakowski, S. M. (2000). Racial differences in treatment of adolescents with bipolar disorder. The American Journal of Psychiatry, 157, 837–838.Google Scholar
DelBello, M. P., & Geller, B. (2001). Review of studies of child and adolescent offspring of bipolar parents. Bipolar Disorders, 3, 325–334.Google Scholar
DelBello, M. P., Schwiers, M. L., Rosenberg, H. L., & Strakowski, S. M. (2002). A double-blind, randomized, placebo-controlled study of quetiapine as adjunctive treatment for adolescent mania. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 1216–1223.Google Scholar
Dell'Osso, L., Pini, S., Cassano, G. B., Mastrocinque, C., Seckinger, R. A., Saettoni, M., et al. (2002). Insight into illness in patients with mania, mixed mania, bipolar depression and major depression with psychotic features. Bipolar Disorders, 4, 315–322.Google Scholar
Deltito, J., Martin, L., Riefkohl, J., Austria, B., Kissilenko, A., & Corless, C. M. P. (2001). Do patients with borderline personality disorder belong to the bipolar spectrum? Journal of Affective Disorders, 67, 221–228.Google Scholar
Depue, R. A., & Collins, P. F. (1999). Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion. Behavioral and Brain Sciences, 22, 491–569.Google Scholar
Depue, R. A., Kleiman, R. M., Davis, P., Hutchinson, M., & Krauss, S. P. (1985). The behavioral high-risk paradigm and bipolar affective disorder, VIII: Serum free cortisol in nonpatient cyclothymic subjects selected by the General Behavior Inventory. The American Journal of Psychiatry, 142, 175–181.Google Scholar
Depue, R. A., & Lenzenweger, M. F. (2001). A neurobehavioral dimensional model. In W. J. Livesley (Ed.), Handbook of personality disorders: Theory, research, and treatment (pp. 136–176). New York: Guilford Press.
Depue, R. A., Slater, J. F., Wolfstetter-Kausch, H., Klein, D. N., Goplerud, E., & Farr, D. A. (1981). A behavioral paradigm for identifying persons at risk for bipolar depressive disorder: A conceptual framework and five validation studies. Journal of Abnormal Psychology, 90, 381–437.Google Scholar
Dickstein, D., Treland, J., Snow, J., McClure, E. B., Mehta, M., Towbin, K. E., et al. (2004). Neuropsychological performance in pediatric bipolar disorder. Biological Psychiatry, 55, 32–39.Google Scholar
Drotar, D., Stein, R. E. K., & Perrin, E. C. (1995). Methodological issues in using the Child Behavior Checklist and its related instruments in clinical child psychology research (Special Issue: Methodological issues in clinical child psychology research). Journal of Clinical Child Psychology, 24, 184–192.Google Scholar
Duffy, A., Alda, M., Kutcher, S., Cavazzoni, P., Robertson, C., Grof, E., et al. (2002). A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment. The Journal of Clinical Psychiatry, 63, 1171–1178.Google Scholar
Embretson, S. E., & Reise, S. P. (2000). The new rules of measurement. In S. E. Embretson & S. P. Reise (Eds.), Item response theory for psychologists (pp. 13–39). Mahwah, NJ: Erlbaum.
Epley, N., & Gilovich, T. (2004). Are adjustments insufficient? Personality and Social Psychology Bulletin, 30, 447–460.Google Scholar
Faraone, S. V., Tsuang, M. T., & Tsuang, D. W. (1999). Genetics of mental disorders. New York: Guilford Press.
Feeny, N. C., Danielson, C. K., Schwartz, L., Youngstrom, E. A., & Findling, R. L. (in press). CBT for bipolar disorders in adolescence: A pilot study. Bipolar Disorders.
Findling, R. L., Gracious, B. L., McNamara, N. K., Youngstrom, E. A., Demeter, C., & Calabrese, J. R. (2001). Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disorders, 3, 202–210.Google Scholar
Findling, R. L., McNamara, N. K., Gracious, B. L., Youngstrom, E. A., Stansbrey, R. J., Reed, M. D., et al. (2003). Combination lithium and divalproex in pediatric bipolarity. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 895–901.Google Scholar
Findling, R. L., Youngstrom, E. A., Danielson, C. K., DelPorto, D., Papish David, R., Townsend, L., et al. (2002). Clinical decision-making using the General Behavior Inventory in juvenile bipolarity. Bipolar Disorders, 4, 34–42.Google Scholar
Findling, R. L., Youngstrom, E. A., McNamara, N. K., Stansbrey, R. J., Demeter, C. A., Bedoya, D., et al. (2005). Early symptoms of mania and the role of parental risk. Bipolar Disorders, 7, 623–634.Google Scholar
Frazier, T. W., & Youngstrom, E. A. (in press). Evidence based assessment of attention-deficit/hyperactivity disorder: Using multiple sources of information. Journal of the American Academy of Child & Adolescent Psychiatry.
Fristad, M. A., Glickman, A. R., Verducci, J. S., Teare, M., Weller, E. B., & Weller, R. A. (1998). Study V: Children's Interview for Psychiatric Syndromes (ChIPS): Psychometrics in two community samples. Journal of Child and Adolescent Psychopharmacology, 8, 237–245.Google Scholar
Fristad, M. A., Teare, M., Weller, E. B., Weller, R. A., & Salmon, P. (1998). Study III: Development and concurrent validity of the Children's Interview for Psychiatric Syndromes—Parent Version (P-ChIPS). Journal of Child and Adolescent Psychopharmacology, 8, 221–226.Google Scholar
Fristad, M. A., Weller, E. B., & Weller, R. A. (1992). The mania rating scale: Can it be used in children? A preliminary report. Journal of the American Academy of Child & Adolescent Psychiatry, 31, 252–257.Google Scholar
Fristad, M. A., Weller, R. A., & Weller, E. B. (1995). The mania rating scale (MRS): Further reliability and validity studies with children. Annals of Clinical Psychiatry, 7, 127–132.Google Scholar
Gadow, K. D., & Sprafkin, J. (1994). Child Symptom Inventories Manual. Stony Brook, NY: Checkmate Plus.
Gadow, K. D., Sprafkin, J., & Weiss, M. D. (2004). Adult Self-Report Inventory 4 manual. Stony Brook, NY: Checkmate Plus.
Galanter, C., Carlson, G., Jensen, P., Greenhill, L., Davies, M., Li, W., et al. (2003). Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder Titration Trial. Journal of Child and Adolescent Psychopharmacology, 13, 123–136.Google Scholar
Geller, B., Craney, J. L., Bolhofner, K., DelBello, M. P., Axelson, D., Luby, J., et al. (2003). Phenomenology and longitudinal course of children with a prepubertal and early adolescent bipolar disorder phenotype. In B. Geller & M. P. DelBello (Eds.), Bipolar disorder in childhood and early adolescence (pp. 25–50). New York: Guilford Press.
Geller, B., & Luby, J. (1997). Child and adolescent bipolar disorder: A review of the past 10 years. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 1168–1176.Google Scholar
Geller, B., Tillman, R., Craney, J. L., & Bolhofner, K. (2004). Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Archives of General Psychiatry, 61, 459–467.Google Scholar
Geller, B., Warner, K., Williams, M., & Zimerman, B. (1998). Prepubertal and young adolescent bipolarity versus ADHD: Assessment and validity using the WASH-U-K-SADS, CBCL and TRF. Journal of Affective Disorders, 51, 93–100.Google Scholar
Geller, B., Zimerman, B., Williams, M., Bolhofner, K., Craney, J. L., DelBello, M. P., et al. (2001). Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-K-SADS) mania and rapid cycling sections. Journal of the American Academy of Child & Adolescent Psychiatry, 40, 450–455.Google Scholar
Geller, B., Zimerman, B., Williams, M., Delbello, M. P., Frazier, J., & Beringer, L. (2002). Phenomenology of prepubertal and early adolescent bipolar disorder: Examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality. Journal of Child & Adolescent Psychopharmacology, 12, 3–9.Google Scholar
Ghaemi, N. S., Miller, C. J., Berv, D. A., Klugman, J., Rosenquist, K. J., & Pies, R. W. (2005). Sensitivity and specificity of a new bipolar spectrum diagnostic scale. Journal of Affective Disorders, 84, 273–277.Google Scholar
Ghaemi, S. N., Ko, J. Y., & Goodwin, F. K. (2002). “Cade's disease” and beyond: Misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder. Canadian Journal of Psychiatry, 47, 125–134.Google Scholar
Glovinsky, I. (2002). A brief history of childhood-onset bipolar disorder through 1980. Child and Adolescent Psychiatric Clinics of North America, 11, 443–460.Google Scholar
Gracious, B. L., Youngstrom, E. A., Findling, R. L., & Calabrese, J. R. (2002). Discriminative validity of a parent version of the Young Mania Rating Scale. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 1350–1359.Google Scholar
Greves, E. H. (1884). Acute mania in a child of five years; Recovery; remarks. Lancet, 2, 824–826.Google Scholar
Guyatt, G. H., & Rennie, D. (Eds.). (2002). Users' guides to the medical literature. Chicago: AMA Press.
Hammen, C., Burge, D., & Adrian, C. (1991). Timing of mother and child depression in a longitudinal study of children at risk. Journal of Consulting and Clinical Psychology, 59, 341–345.Google Scholar
Hammen, C., Burge, D., Burney, E., & Adrian, C. (1990). Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder. Archives of General Psychiatry, 47, 1112–1117.Google Scholar
Hammen, C. L., Adrian, C., Gordon, D., Jaenicke, C., & Hiroto, D. (1987). Children of depressed mothers: Maternal strain and symptom predictors of dysfunction. Journal of Abnormal Psychology, 96, 190–198.Google Scholar
Hanley, J. A., & McNeil, B. J. (1983). A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology, 148, 839–843.Google Scholar
Hazell, P., Carr, V., Lewin, T. J., & Sly, K. (2003). Manic symptoms in young males with ADHD predict functioning but not diagnosis after 6 years. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 552–560.Google Scholar
Hazell, P. L., Lewin, T. J., & Carr, V. J. (1999). Confirmation that Child Behavior Checklist clinical scales discriminate juvenile mania from attention deficit hyperactivity disorder. Journal of Paediatrics and Child Health, 35, 199–203.Google Scholar
Hellander, M. (2002). Lithium testing in children: A public health necessity. Washington, DC: Testimony to the Food and Drug Administration.
Hirschfeld, R. M., Williams, J. B., Spitzer, R. L., Calabrese, J. R., Flynn, L., Keck, P. E., Jr., et al. (2000). Development and validation of a screening instrument for bipolar spectrum disorder: The Mood Disorder Questionnaire. The American Journal of Psychiatry, 157, 1873–1875.Google Scholar
Hodgins, S., Faucher, B., Zarac, A., & Ellenbogen, M. (2002). Children of parents with bipolar disorder. A population at high risk for major affective disorders. Child and Adolescent Psychiatric Clinics of North America, 11, 533–553.Google Scholar
Hudziak, J. J., Althoff, R. R., Derks, E. M., Faraone, S. V., & Boomsma, D. I. (2005). Prevalence and genetic architecture of Child Behavior Checklist—Juvenile bipolar disorder. Biological Psychiatry, 58, 562–568.Google Scholar
Hudziak, J. J., van Beijsterveldt, C. E. M., Bartels, M., Rietveld, M. J. H., Rettew, D. C., Derks, E. M., et al. (2003). Individual differences in aggression: Genetic analyses by age, gender, and informant in 3-, 7-, and 10-year-old Dutch twins. Behavior Genetics, 33, 575–589.Google Scholar
Jaeschke, R., Guyatt, G. H., & Sackett, D. L. (1994a). Users' guides to the medical literature: III. How to use an article about a diagnostic test: A. Are the results of the study valid? Journal of the American Medical Association, 271, 389–391.Google Scholar
Jaeschke, R., Guyatt, G. H., & Sackett, D. L. (1994b). Users' guides to the medical literature: III. How to use an article about a diagnostic test: B: What are the results and will they help me in caring for my patients? Journal of the American Medical Association, 271, 389–391.Google Scholar
Judd, L. L., & Akiskal, H. S. (2003). The prevalence and disability of bipolar spectrum disorders in the US population: Re-analysis of the ECA database taking into account subthreshold cases. Journal of Affective Disorders, 73, 123–131.Google Scholar
Kahana, S. Y., Youngstrom, E. A., Findling, R. L., & Calabrese, J. R. (2003). Employing parent, teacher, and YSR checklists in identifying pediatric bipolar spectrum disorders: An examination of diagnostic accuracy and clinical utility. Journal of Child and Adolescent Psychopharmacology, 13, 471–488.Google Scholar
Kasanin, J. (1931). The affective psychoses in children. American Journal of Psychiatry, 10, 897–926.Google Scholar
Kasen, S., Cohen, P., Skodol, A. E., Johnson, J. G., Smailes, E., & Brook, J. (2001). Childhood depression and adult personality disorder: Alternative pathways of continuity. Archives of General Psychiatry, 58, 231–236.Google Scholar
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980–988.Google Scholar
Kendler, K. S., Prescott, C. A., Jacobson, K., Myers, J., & Neale, M. C. (2002). The joint analysis of personal interview and family history diagnoses: Evidence for validity of diagnosis and increased heritability estimates. Psychological Medicine, 32, 829–842.Google Scholar
Kendler, K. S., & Roy, M.-A. (1995). Validity of a diagnosis of lifetime major depression obtained by personal interview versus family history. The American Journal of Psychiatry, 152, 1608–1614.Google Scholar
Kessler, R. C., Berglund, P., Demler, O., Jin, R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 593–602.Google Scholar
Kessler, R. C., Rubinow, D. R., Holmes, C., Abelson, J. M., & Zhao, S. (1997). The epidemiology of DSM-III-R bipolar I disorder in a general population survey. Psychological Medicine, 27, 1079–1089.Google Scholar
Kim, E. Y., & Miklowitz, D. J. (2002). Childhood mania, attention deficit hyperactivity disorder and conduct disorder: A critical review of diagnostic dilemmas. Bipolar Disorders, 4, 215–225.Google Scholar
Klein, R. G., Pine, D. S., & Klein, D. F. (1998). Resolved: Mania is mistaken for ADHD in prepubertal children. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 1093–1096.Google Scholar
Kluger, J., & Song, S. (2002). Young and bipolar. Time, August 19, 39–47, 51.
Kogan, J. N., Otto, M. W., Bauer, M. S., Dennehy, E. B., Miklowitz, D. J., Zhang, H.-W., et al. (2004). Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Bipolar Disorders, 6, 460–469.Google Scholar
Kovacs, M. (1989). Affective disorders in children and adolescents (Special Issue: Children and their development: Knowledge base, research agenda, and social policy application). American Psychologist, 44, 209–215.Google Scholar
Kowatch, R. A., Suppes, T., Carmody, T. J., Bucci, J. P., Hume, J. H., Kromelis, M., et al. (2000). Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 39, 713–720.Google Scholar
Kowatch, R. A., Youngstrom, E. A., Danielyan, A., & Findling, R. L. (2005). Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disorders, 7, 483–496.Google Scholar
Kraemer, H. C. (1992). Evaluating medical tests: Objective and quantitative guidelines. Newbury Park, CA: Sage.
Kraepelin, E. (1921). Manic-depressive insanity and paranoia. Edinburgh: Livingstone.
Kutcher, S. P., Marton, P., & Korenblum, M. (1990). Adolescent bipolar illness and personality disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 29, 355–358.Google Scholar
Kwapil, T. R., Miller, M. B., Zinser, M. C., Chapman, L. J., Chapman, J., & Eckblad, M. (2000). A longitudinal study of high scorers on the hypomanic personality scale. Journal of Abnormal Psychology, 109, 222–226.Google Scholar
Lapalme, M., Hodgins, S., & LaRoche, C. (1997). Children of parents with bipolar disorder: A metaanalysis of risk for mental disorders. Canadian Journal of Psychiatry, 42, 623–631.Google Scholar
Leibenluft, E., Charney, D. S., Towbin, K. E., Bhangoo, R. K., & Pine, D. S. (2003). Defining clinical phenotypes of juvenile mania. The American Journal of Psychiatry, 160, 430–437.Google Scholar
Lewinsohn, P. M., Klein, D. N., & Seeley, J. (2000). Bipolar disorder during adolescence and young adulthood in a community sample. Bipolar Disorders, 2, 281–293.Google Scholar
Lewinsohn, P. M., Klein, D. N., & Seeley, J. R. (1995). Bipolar disorders in a community sample of older adolescents: Prevalence, phenomenology, comorbidity, and course. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 454–463.Google Scholar
Lewinsohn, P. M., Seeley, J. R., Buckley, M. E., & Klein, D. N. (2002). Bipolar disorder in adolescence and young adulthood. Child and Adolescent Psychiatric Clinics of North America, 11, 461–476.Google Scholar
Loeber, R., Green, S. M., & Lahey, B. B. (1990). Mental health professionals' perception of the utility of children, mothers, and teachers as informants on childhood psychopathology. Journal of Clinical Child Psychology, 19, 136–143.Google Scholar
Lofthouse, N., & Fristad, M. (2004). Psychosocial interventions for children with early-onset bipolar spectrum disorder. Clinical Child and Family Psychology Review, 21, 71–89.Google Scholar
MacKinnon, D., & Pies, R. (2006). Affective instability as rapid cycling: Theoretical and clinical implications for borderline personality and bipolar spectrum disorders. Bipolar Disorders, 8, 1–14.Google Scholar
MacKinnon, D. F., Zandi, P. P., Gershon, E., Nurnberger, J., Reich, T., & DePaulo, R. (2003). Rapid switching of mood in families with multiple cases of bipolar disorder. Archives of General Psychiatry, 60, 921–928.Google Scholar
McGuffin, P., Rijsdijk, F., Andrew, M., Sham, P., Katz, R., & Cardno, A. (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Archives of General Psychiatry, 60, 497–502.Google Scholar
Mick, E., Biederman, J., Pandina, G., & Faraone, S. V. (2003). A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder. Biological Psychiatry, 53, 1021–1027.Google Scholar
Miklowitz, D. J., & Alloy, L. B. (1999). Psychosocial factors in the course and treatment of bipolar disorder: Introduction to the special section. Journal of Abnormal Psychology, 108, 555–557.Google Scholar
Miklowitz, D. J., George, E. L., Axelson, D. A., Kim, E. Y., Birmaher, B., Schneck, C., et al. (2004). Family-focused treatment for adolescents with bipolar disorder. Journal of Affective Disorders, 82(Suppl. 1), S113–S128.Google Scholar
Miklowitz, D. J., George, E. L., Richards, J. A., Simoneau, T. L., & Suddath, R. L. (2003). A randomized study of family focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Archives of General Psychiatry, 60, 904–912.Google Scholar
Miklowitz, D. J., Goldstein, M. J., Nuechterlein, K. H., Snyder, K. S. (1988). Family factors and the course of bipolar affective disorder. Archives of General Psychiatry, 45, 225–231.Google Scholar
Miller, C. J., Klugman, J., Berv, D. A., Rosenquist, K. J., & Ghaemi, S. N. (2004). Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. Journal of Affective Disorders, 81, 167–171.Google Scholar
Naylor, M. W., Anderson, T. R., Kruesi, M. J., & Stoewe, M. (2002, October). Pharmacoepidemiology of bipolar disorder in abused and neglected state wards. Poster presented at the National Meeting of the American Academy of Child & Adolescent Psychiatry, San Francisco, CA.
Neighbors, H. W., Trierweiler, S. J., Ford, B. C., & Muroff, J. R. (2003). Racial differences in DSM diagnosis using a semi-structured instrument: The importance of clinical judgment in the diagnosis of African Americans. Journal of Health and Social Behavior, 44, 237–256.Google Scholar
Nottelmann, E., Biederman, J., Birmaher, B., Carlson, G. A., Chang, K. D., Fenton, W. S., et al. (2001). National Institute of Mental Health Research roundtable on prepubertal bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 40, 871–878.Google Scholar
O'Connell, R. A., Mayo, J. A., & Sciutto, M. S. (1991). PDQ-R personality disorders in bipolar patients. Journal of Affective Disorders, 23, 217–221.Google Scholar
Orvaschel, H. (1995). Schizophrenia and Affective Disorders Schedule for Children—Epidemiological version (K-SADS-E). Unpublished manuscript, Nova University.
Papolos, D. F., & Papolos, J. (2002). The bipolar child: The definitive and reassuring guide to childhood's most misunderstood disorder (2nd ed.). New York: Broadway Books.
Pavuluri, M. (2002, September). Prospective treatment study/reliability and validity of the Child Bipolar Rating Scale—Parent/teacher version (CBRS-P/T). Paper presented at the NIMH Roundtable on the Broad Phenotype of Juvenile Bipolar Disorder, Bethesda, MD.
Pelham, J. W. E., Fabiano, G. A., & Massetti, G. M. (2005). Evidence-based assessment of attention deficit hyperactivity disorder in children and adolescents. Journal of Clinical Child and Adolescent Psychiatry, 34, 449–476.Google Scholar
Pini, S., Dell'Osso, L., & Amador, X. F. (2001). Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. The American Journal of Psychiatry, 158, 122–125.Google Scholar
Pliszka, S. R., Sherman, J. O., Barrow, M. V., & Irick, S. (2000). Affective disorder in juvenile offenders: A preliminary study. The American Journal of Psychiatry, 157, 130–132.Google Scholar
Post, R., Leverich, G., Luckenbaugh, D., Altshuler, L., Frye, M. A., Suppes, T., et al. (2006, April). An excess of childhood-onset bipolar illness in the United States compared with Europe. Paper presented at the NIMH Pediatric Bipolar Disorder Conference, Chicago.
Poznanski, E. O., Miller, E., Salguero, C., & Kelsh, R. C. (1984). Preliminary studies of the reliability and validity of the Children's Depression Rating Scale. Journal of the American Academy of Child Psychiatry, 23, 191–197.Google Scholar
Radke-Yarrow, M. (1998). Children of depressed mothers: From early childhood to maturity. Cambridge, MA: Cambridge Univ Press.
Reichart, C. G., van der Ende, J., Wals, M., Hillegers, M. H., Ormel, J., Nolen, W. A., et al. (2004). The use of the GBI in a population of adolescent offspring of parents with a bipolar disorder. Journal of Affective Disorders, 80, 263–267.Google Scholar
Richters, J. E. (1992). Depressed mothers as informants about their children: A critical review of the evidence for distortion. Psychological Bulletin, 112, 485–499.Google Scholar
Robins, E., & Guze, S. B. (1970). Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. The American Journal of Psychiatry, 126, 983–986.Google Scholar
Sackett, D. L., Straus, S. E., Richardson, W. S., Rosenberg, W., & Haynes, R. B. (2000). Evidence-based medicine: How to practice and teach EBM (2nd ed.). New York: Churchill Livingstone.
Sattler, J. M. (1998). Clinical and forensic interviewing of children and families: Guidelines for the mental health, education, pediatric, and child maltreatment fields. San Diego, CA: Jerome M. Sattler Publisher.
Schneck, C. D., Miklowitz, D. J., Calabrese, J. R., Allen, M. H., Thomas, M. R., Wisniewski, S. R., et al. (2004). Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program. The American Journal of Psychiatry, 161, 1902–1908.Google Scholar
Shiner, R. L. (1998). How shall we speak of children's personalities in middle childhood? A preliminary taxonomy. Psychological Bulletin, 124, 308–332.Google Scholar
Soutullo, C. A., Chang, K. D., Diez-Suarez, A., Figueroa-Quintana, A., Escamilla-Canales, I., Rapado-Castro, M., et al. (2005). Bipolar disorder in children and adolescents: International perspective on epidemiology and phenomenology. Bipolar Disorders, 7, 497–506.Google Scholar
Strakowski, S. M., Hawkins, J. M., Keck, P. E., Jr., McElroy, S. L., West, S. A., Bourne, M. L., et al. (1997). The effects of race and information variance on disagreement between psychiatric emergency service and research diagnoses in first-episode psychosis. The Journal of Clinical Psychiatry, 58, 457–463.Google Scholar
Swets, J. A., Dawes, R. M., & Monahan, J. (2000). Psychological science can improve diagnostic decisions. Psychological Science in the Public Interest, 1, 1–26.Google Scholar
Teplin, L. A., Abram, K. M., McClelland, G. M., Dulcan, M. K., & Mericle, A. A. (2002). Psychiatric disorders in youth in juvenile detention. Archives of General Psychiatry, 59, 1133–1143.Google Scholar
Thuppal, M., Carlson, G. A., Sprafkin, J., & Gadow, K. D. (2002). Correspondence between adolescent report, parent report, and teacher report of manic symptoms. Journal of Child and Adolescent Psychopharmacology, 12, 27–35.Google Scholar
Tillman, R., & Geller, B. (2005). A brief screening tool for a prepubertal and early adolescent bipolar disorder phenotype. The American Journal of Psychiatry, 162, 1214–1216.Google Scholar
Tillman, R., Geller, B., Craney, J. L., Bolhofner, K., Williams, M., & Zimerman, B. (2004). Relationship of parent and child informants to prevalence of mania symptoms in children with a prepubertal and early adolescent bipolar disorder phenotype. The American Journal of Psychiatry, 161, 1278–1284.Google Scholar
Toichi, M., Findling, R. L., Youngstrom, E. A., McNamara, N. K., Gracious, B. L., Kubota, Y., et al. (2006). Impaired prefrontal lobe function in juvenile bipolar disorder during manic episodes. Manuscript submitted for publication.
Tramontina, S., Schmitz, M., Polanczyk, G., & Rohde, L. A. (2003). Juvenile bipolar disorder in Brazil: Clinical and treatment findings. Biological Psychiatry, 53, 1043–1049.Google Scholar
Tsuchiya, K. J., Byrne, M., & Mortensen, P. B. (2003). Risk factors in relation to an emergence of bipolar disorder: A systematic review. Bipolar Disorders, 5, 231–242.Google Scholar
Weckerly, J. (2002). Pediatric bipolar mood disorder. Journal of Developmental and Behavioral Pediatrics, 23, 42–56.Google Scholar
Weinberg, W. A., & Brumback, R. A. (1976). Mania in childhood: Case studies and literature review. American Journal of Diseases of Children, 130, 380–385.Google Scholar
Wozniak, J., Biederman, J., Kiely, K., Ablon, J. S., Faraone, S., Mundy, E., et al. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. Journal of the American Academy of Child & Adolescent Psychiatry, 34, 867–876.Google Scholar
Yeh, M., & Weisz, J. (2001). Why are we here at the clinic? Parent–child (dis)agreement on referral problems at outpatient treatment entry. Journal of Consulting and Clinical Psychology, 69, 1018–1025.Google Scholar
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978). A rating scale for mania: Reliability, validity, and sensitivity. British Journal of Psychiatry, 133, 429–435.Google Scholar
Youngstrom, E. A. (1999, April). Caregiver dysphoria (but not antisocial behavior) predicts disagreement with teacher-rated behavior problems. Paper presented at the Biennial Meeting of the Society for Research on Child Development Albuquerque, NM.
Youngstrom, E. A., Ackerman, B. P., & Izard, C. E. (1999). Dysphoria-related bias in maternal ratings of children. Journal of Consulting and Clinical Psychology, 67, 905–916.Google Scholar
Youngstrom, E. A., & Duax, J. (2005). Evidence based assessment of pediatric bipolar disorder, part 1: Base rate and family history. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 712–717.Google Scholar
Youngstrom, E. A., Findling, R. L., & Calabrese, J. R. (2003). Who are the comorbid adolescents? Agreement between psychiatric diagnosis, parent, teacher, and youth report. Journal of Abnormal Child Psychology, 31, 231–245.Google Scholar
Youngstrom, E. A., Findling, R. L., & Calabrese, J. R. (2004). Effects of adolescent manic symptoms on agreement between youth, parent, and teacher ratings of behavior problems. Journal of Affective Disorders, 82(Suppl. 1), S5–S16.Google Scholar
Youngstrom, E. A., Findling, R. L., Calabrese, J. R., Gracious, B. L., Demeter, C., DelPorto Bedoya, D., et al. (2004). Comparing the diagnostic accuracy of six potential screening instruments for bipolar disorder in youths aged 5 to 17 years. Journal of the American Academy of Child & Adolescent Psychiatry, 43, 847–858.Google Scholar
Youngstrom, E. A., Findling, R. L., Danielson, C. K., & Calabrese, J. R. (2001). Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior Inventory. Psychological Assessment, 13, 267–276.Google Scholar
Youngstrom, E. A., Findling, R. L., Kogos Youngstrom, J., & Calabrese, J. R. (2005). Toward an evidence-based assessment of pediatric bipolar disorder. Journal of Clinical Child and Adolescent Psychology, 34, 433–448.Google Scholar
Youngstrom, E. A., Findling, R. L., Sachs, G., Carlson, G. A., Kafantaris, V., Wozniak, J., et al. (2003, March). Manic symptoms in bipolar and nonbipolar youths across eleven research groups using the Young Mania Rating Scale. Paper presented at the NIMH Conference on Pediatric Bipolar Disorder, Washington, DC.
Youngstrom, E. A., Frazier, T. W., Findling, R. L., & Calabrese, J. R. (2006). Developing a ten item short form of the Parent General Behavior Inventory to assess for juvenile mania and hypomania. Manuscript submitted for publication.
Youngstrom, E. A., Gracious, B. L., Danielson, C. K., Findling, R. L., & Calabrese, J. R. (2003). Toward an integration of parent and clinician report on the Young Mania Rating Scale. Journal of Affective Disorders, 77, 179–190.Google Scholar
Youngstrom, E. A., & Kogos Youngstrom, J. (2005). Evidence based assessment of pediatric bipolar disorder, part 2: Incorporating information from behavior checklists. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 823–828.Google Scholar
Youngstrom, E. A., Loeber, R., & Stouthamer-Loeber, M. (2000). Patterns and correlates of agreement between parent, teacher, and male adolescent ratings of externalizing and internalizing problems. Journal of Consulting and Clinical Psychology, 68, 1038–1050.Google Scholar
Youngstrom, E. A., Meyers, O. I., Demeter, C., Kogos Youngstrom, J., Morello, L., Piiparinen, R., et al. (2005). Comparing diagnostic checklists for pediatric bipolar disorder in academic and community mental health settings. Bipolar Disorders, 7, 507–517.Google Scholar
Youngstrom, E. A., Meyers, O. I., Youngstrom, J. K., Calabrese, J. R., & Findling, R. L. (in press). Comparing the effects of sampling designs on the diagnostic accuracy of eight promising screening instruments for pediatric bipolar disorder. Biological Psychiatry.
Youngstrom, E. A., Youngstrom, J. K., Meyers, O. I., Feeny, N. C., Calabrese, J. R., & Findling, R. L. (2004, October). Examining Achenbach CBCL profiles as a proxy for bipolar diagnosis. Paper presented at the Annual Meeting of the American Academy of Child & Adolescent Psychiatry, Washington, DC.
Youngstrom, E. A., Youngstrom, J. K., & Starr, M. (2005). Bipolar diagnoses in community mental health: Achenbach CBCL profiles and patterns of comorbidity. Biological Psychiatry, 58, 569–575.Google Scholar
Zhou, X.-H., Obuchowski, N. A., & McClish, D. K. (2002). Statistical methods in diagnostic medicine. New York: Wiley.
Zubin, J., & Gurland, B. J. (1977). The United States–United Kingdom project on diagnosis of the mental disorders. Annals of the New York Academy of Sciences, 285, 676–686.Google Scholar