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Coping with having a depressed mother: The role of stress and coping in hypothalamic–pituitary–adrenal axis dysfunction in girls at familial risk for major depression

Published online by Cambridge University Press:  25 November 2014

Lara C. Foland-Ross ,
Katharina Kircanski  and
Ian H. Gotlib
Lara C. Foland-Ross*
Affiliation:
Stanford University
Katharina Kircanski
Affiliation:
Stanford University
Ian H. Gotlib
Affiliation:
Stanford University
*
Address correspondence and reprint requests to: Lara Foland-Ross, Stanford Mood and Anxiety Disorders Laboratory, Department of Psychology, Stanford University, Jordan Hall, Building 420, 450 Serra Mall, Stanford, CA 94305; E-mail: [email protected].
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Abstract

Having a depressed mother is one of the strongest predictors of depression in adolescence. We investigated whether the stress of having a mother with recurrent depression is associated with dysfunction in adolescents in the HPA axis and whether the tendency to use involuntary coping strategies in dealing with this stress is associated with exacerbation of dysfunction in this system. Sixty-four never-disordered daughters of mothers with recurrent depression (high risk) and 64 never-disordered daughters of never-disordered mothers (low risk) completed diurnal cortisol and stress assessments. High-risk girls secreted more diurnal cortisol than did low-risk girls. Whereas low-risk girls secreted higher levels of cortisol with increasing stress associated with having a depressed mother, no such relation was present in high-risk girls. Finally, in contrast to low-risk girls, girls at familial risk for depression who more frequently used involuntary versus voluntary coping exhibited the greatest elevations in diurnal cortisol. These findings indicate that a tendency to utilize involuntary, as opposed to voluntary, coping strategies in dealing with stress involving maternal depression exacerbates already high levels of cortisol in youth at risk for depression. Future research that examines whether interventions aimed at increasing the use of voluntary coping strategies normalizes HPA axis dysfunction is of interest.

Type
Regular Articles
Information
Development and Psychopathology , Volume 26 , Special Issue 4pt2: Multilevel Developmental Perspectives Toward Understanding Internalizing Psychopathology: Current Research and Future Directions , November 2014 , pp. 1401 - 1409
Copyright
Copyright © Cambridge University Press 2014 

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References

Abelson, J. L., Khan, S., Liberzon, I., Erickson, T. M., & Young, E. A. (2008). Effects of perceived control and cognitive coping on endocrine stress responses to pharmacological activation. Biological Psychiatry, 64, 701–707.CrossRefGoogle ScholarPubMed
Adam, E. K., Doane, L. D., Zinbarg, R. E., Mineka, S., Craske, M. G., & Griffith, J. W. (2010). Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology, 35, 921–931.CrossRefGoogle ScholarPubMed
Adrian, C., & Hammen, C. (1993). Stress exposure and stress generation in children of depressed mothers. Journal of Consulting and Clinical Psychology, 61, 354–359.Google Scholar
Beardslee, W. R., Versage, E. M., & Gladstone, T. R. (1998). Children of affectively ill parents: A review of the last 10 years. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 11134–11141.Google Scholar
Chen, M., Joormann, J., Hallmayer, J., & Gotlib, I. (2010). Serotonin transporter polymorphism predicts waking cortisol in young girls. Psychoneuroendocrinology, 34, 681–686.Google Scholar
Cohen, J., & Cohen, P. (1983). Applied multiple regression/correlation analysis for the behavioral science (2nd ed.). Hillsdale, NJ: Erlbaum.Google Scholar
Compas, B. E., Champion, J. E., Forehand, R., Cole, D. A., Reeslund, K. L., Fear, J., et al. (2010). Coping and parenting: Mediators of 12-month outcomes of a family group cognitive–behavioral preventive intervention with families of depressed parents. Journal of Consulting and Clinical Psychology, 78, 623–634.Google Scholar
Compas, B. E., Forehand, R., Keller, G., Champion, J. E., Rakow, A., Reeslund, K. L., et al. (2009). Randomized controlled trial of a family cognitive–behavioral preventive intervention for children of depressed parents. Journal of Consulting and Clinical Psychology, 77, 1007–1020.CrossRefGoogle ScholarPubMed
Compas, B. E., Langrock, A. M., Keller, G., Merchant, M. J., & Copeland, M. E. (2002). Children coping with parental depression: Processes of adaptation to family stress. In Goodman, S. & Gotlib, I. H. (Eds.), Children of depressed parents: Alternative pathways to risk for psychopathology (pp. 227–252). Washington, DC: American Psychological Association.Google Scholar
Connell, A. M., & Goodman, S. H. (2002). The association between psychopathology in fathers versus mothers and children's internalizing and externalizing behavior problems: A meta-analysis. Psychological Bulletin, 128, 746–773.CrossRefGoogle ScholarPubMed
Connor-Smith, J., Compas, B., Wadsworth, M., Thomsen, A., & Saltzman, H. (2000). Responses to stress in adolescence: Measurement of coping and involuntary stress responses. Journal of Consulting and Clinical Psychology, 68, 976–992.Google Scholar
Dickerson, S. S., & Kemeny, M. E. (2004). Acute stressors and cortisol responses: A theoretical integration and synthesis of laboratory research. Psychological Bulletin, 130, 355–391.CrossRefGoogle ScholarPubMed
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). Structured Clinical Interview for DSM-IV Axis I Disorders—Clinician version (SCID-CV). Washington, DC: American Psychiatric Press.Google Scholar
Folkman, S., & Moskowitz, J. T. (2004). Coping: Pitfalls and promise. Annual Review of Psychology, 55, 745–774.Google Scholar
Gelfand, D. M., & Teti, D. M. (1990). The effects of maternal depression on children. Clinical Psychology Review, 106, 329–353.Google Scholar
Goodyer, I. M., Herbert, J., & Altham, P. M. E. (2000). Adrenal steroid secretion and major depression in 8- to 16-year-olds. III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression. Psychological Medicine, 28, 265–273.Google Scholar
Hammen, C. (1997). Children of depressed parents: The stress context. In Wolchik, S. A. & Sandler, I. N. (Eds.), Handbook of children's coping: Linking theory and intervention (pp. 131–157). New York: Perseus.CrossRefGoogle Scholar
Hammen, C. (2002). Context of stress within families of children with depressed parents. In Goodman, S. & Gotlib, I. H. (Eds.), Children of depressed parents: Alternative pathways to risk for psychopathology (pp. 175–199). Washington, DC: American Psychological Association.Google Scholar
Hammen, C., Brennan, P. A., & Shih, J. H. (2004). Family discord and stress predictors of depression and other disorders in adolescent children of depressed and nondepressed women. Journal of the American Academy of Child & Adolescent Psychiatry, 43, 994–1002.Google Scholar
Hori, H., Teraishi, T., Ota, M., Hattori, K., Matsuo, J., Kinoshita, Y., et al. (in press). Psychological coping in depressed outpatients: Association with cortisol response to the combined dexamethasone/CRH test. Journal of Affective Disorders.Google Scholar
Jaser, S. S., Champion, J. E., Dharamsi, K. R., Riesing, M. M., & Compas, B. E. (2011). Coping and positive affect in adolescents of mothers with and without a history of depression. Journal of Child and Family Studies, 20, 353–360.Google Scholar
Jaser, S. S., Fear, J. M., Reeslund, K. L., Champion, J. E., Reising, M. M., & Compas, B. E. (2008). Maternal sadness and adolescents’ responses to stress in offspring of mothers with and without a history of depression. Journal of Clinical Child and Adolescent Psychology, 37, 736–746.Google Scholar
Jaser, S. S., Langrock, A. M., Keller, G., Merchant, M. J., Benson, M. A., Reeslund, K., et al. (2005). Coping with the stress of parental depression II: Adolescent and parent reports of coping and adjustment. Journal of Clinical Child and Adolescent Psychology, 34, 193–205.Google Scholar
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980–988.Google Scholar
Kovacs, M. (1992). The Children's Depression Inventory (CDI). North Tonawanda, NY: Multi-Health Systems.Google Scholar
Kupper, N., de Geus, E. J., van den Berg, M., Kirschbaum, C., Boomsma, D. I., & Willemsen, G. (2005). Familial influences on basal salivary cortisol in an adult population. Psychoneuroendochrinology, 30, 857–868.Google Scholar
Langrock, A. M., Compas, B. E., Keller, G., Merchant, M. J., & Copeland, M. E. (2002). Coping with the stress of parental depression: Parents’ reports of children's coping, emotional, and behavioral problems. Journal of Clinical Child and Adolescent Psychology, 31, 312–324.CrossRefGoogle ScholarPubMed
Lazarus, R. S., & Folkman, S. (1984). Stress, appraisal, and coping. New York: Springer.Google Scholar
Lewinsohn, P. M., Rohde, P., Seeley, J. R., Klein, D. N., & Gotlib, I. H. (2000). Natural course of adolescent major depressive disorder in a community sample: Predictors of recurrence in young adults. American Journal of Psychiatry, 157(10), 1584–1591.CrossRefGoogle Scholar
Lieb, R., Isensee, B., Höfler, M., Pfister, H., & Wittchen, H. U. (2002). Parental major depression and the risk of depression and other mental disorders in offspring: A prospective-longitudinal community study. Archives of General Psychiatry, 59, 365–374.Google Scholar
Lovejoy, M. C., Graczyk, P. A., O'Hare, E., & Neuman, G. (2000). Maternal depression and parenting behavior: A meta-analytic review. Clinical Psychology Review, 20, 561–592.CrossRefGoogle ScholarPubMed
Lupien, S. J., King, S., Meaney, M. J., & McEwen, B. S. (2000). Child's stress hormone levels correlate with mother's socioeconomic status and depressive state. Biological Psychiatry, 48, 976–980.Google Scholar
Malphurs, J. E., Field, T. M., Larraine, C., Pickens, J., & Pelaez-Nogueras, M. (1996). Altering withdrawn and intrusive interaction behaviors of depressed mothers. Infant Mental Health Journal, 17, 152–160.Google Scholar
Mannie, Z. N., Harmer, C. J., & Cowen, P. J. (2007). Increased waking salivary cortisol levels in young people at familial risk of depression. American Journal of Psychiatry, 164, 617–621.CrossRefGoogle ScholarPubMed
March, J., Parker, J., Sullivan, K., Stallings, P., & Conners, C. (1997). The Multidimensional Anxiety Scale for Children (MASC): Factor structure, reliability and validity. Journal of the Academy of Child & Adolescent Psychiatry, 36, 554–565.Google Scholar
Monroe, S. M., Slavich, G. M., & Georgiades, K. (2008). The social environment and life stress in depression. In Gotlib, I. H. & Hammen, C. L. (Eds.), Handbook of depression (2nd ed., pp. 340–360). New York: Guilford Press.Google Scholar
Nelson, D. R., Hammen, C., Brennan, P. A., & Ullman, J. B. (2003). The impact of maternal depression on adolescent adjustment: The role of expressed emotion. Journal of Consulting and Clinical Psychology, 71, 935–944.Google Scholar
Nolen-Hoeksema, S., & Hilt, L. M. (2008). Gender differences in depression. In Gotlib, I. H. & Hammen, C. L. (Eds.), Handbook of depression (2nd ed., pp. 386–404). New York: Guilford Press.Google Scholar
O'Donnell, K., Badrick, E., Kumari, M., & Steptoe, A. (2008). Psychological coping styles and cortisol over the day in healthy older adults. Psychoneuroendochrinology, 33, 601–611.Google Scholar
Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendochrinology, 28, 916–931.Google Scholar
Rao, U., Hammen, C. L., & Poland, R. E. (2009). Risk markers for depression in adolescents: Sleep and HPA measures. Neuropsychopharmacology, 34, 1936–1945.Google Scholar
Sawyer, M. G., Pfeiffer, S., & Spence, S. H. (2009). Life events, coping and depressive symptoms among young adolescents: A one-year prospective study. Journal of Affective Disorders, 117, 48–54.Google Scholar
Seifer, R., Dickstein, S., Sameroff, A. J., Magee, K. D., & Hayden, L. C. (2001). Infant mental health and variability of parental depression symptoms. Journal of the Academy of Child & Adolescent Psychiatry, 40, 1375–1382.Google Scholar
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 1552–1562.Google Scholar
Thompson, R. J., Mata, J., Jaeggi, S. M., Buschkuehl, M., Jonides, J., & Gotlib, I. H. (2010). Maladaptive coping, adaptive coping, and depressive symptoms: Variations across age and depressive state. Behavior Research and Therapy, 48, 459–466.CrossRefGoogle ScholarPubMed
Tukey, J. W. (1977). Addison–Wesley series in behavioral science: Quantitative methods (p. 231). Reading, MA: Addison–Wesley.Google Scholar
Vreeburg, S. A., Hartman, C. A., Hoogendijk, W. J., van Dyck, R., Zitman, F. G., Ormel, J., et al. (2010). Parental history of depression or anxiety and the cortisol awakening response. British Journal of Psychiatry, 197, 180–185.Google Scholar
Weschler, D. (1991). The Weschler Intelligence Scale for Children. San Antonio, TX: Psychological Corporation.Google Scholar
Williamson, D. E., Birmaher, B., Axelson, D. A., Ryan, N. D., & Dahl, R. E. (2004). First episode of depression in children at low and high familial risk for depression. Journal of the American Academy of Child & Adolescent Psychiatry, 43, 291–297.CrossRefGoogle ScholarPubMed
Wust, S., Federenko, I., Hellhammer, D. H., & Kirschbaum, C. (2000). Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology, 25, 707–720.Google Scholar