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Childhood trauma and cognitive functioning in individuals at clinical high risk (CHR) for psychosis

Published online by Cambridge University Press:  21 January 2020

T. Velikonja Open the ORCID record for T. Velikonja [Opens in a new window] ,
E. Velthorst ,
J. Zinberg ,
T. D. Cannon ,
B. A. Cornblatt ,
D. O. Perkins ,
K. S. Cadenhead ,
M. T. Tsuang ,
J. Addington  and
S. W. Woods
...Show all authors
T. Velikonja*
Affiliation:
Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, USA Seaver Center of Research and Treatment, Icahn School of Medicine, Mount Sinai, New York, NY, USA
E. Velthorst
Affiliation:
Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, USA Seaver Center of Research and Treatment, Icahn School of Medicine, Mount Sinai, New York, NY, USA
J. Zinberg
Affiliation:
Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California–Los Angeles, Los Angeles, CA, USA
T. D. Cannon
Affiliation:
Department of Psychiatry, Yale University, New Haven, CT, USA
B. A. Cornblatt
Affiliation:
Department of Psychiatry, Zucker Hillside Hospital, Queens, NY, USA
D. O. Perkins
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
K. S. Cadenhead
Affiliation:
Department of Psychiatry, University of California–San Diego, La Jolla, CA, USA
M. T. Tsuang
Affiliation:
Department of Psychiatry, University of California–San Diego, La Jolla, CA, USA
J. Addington
Affiliation:
Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
S. W. Woods
Affiliation:
Department of Psychiatry, Yale University, New Haven, CT, USA
T. McGlashan
Affiliation:
Department of Psychiatry, Yale University, New Haven, CT, USA
D. H. Mathalon
Affiliation:
Department of Psychiatry, University of California–San Francisco, San Francisco, CA, USA
W. Stone
Affiliation:
Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA
M. Keshavan
Affiliation:
Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA
L. Seidman
Affiliation:
Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA
C. E. Bearden
Affiliation:
Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California–Los Angeles, Los Angeles, CA, USA
*
Author for correspondence: Dr. Tjasa Velikonja, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Pl., Psychiatry Box# 1230, New York, NY10029. E-mail: [email protected].
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Abstract

Evidence suggests that early trauma may have a negative effect on cognitive functioning in individuals with psychosis, yet the relationship between childhood trauma and cognition among those at clinical high risk (CHR) for psychosis remains unexplored. Our sample consisted of 626 CHR children and 279 healthy controls who were recruited as part of the North American Prodrome Longitudinal Study 2. Childhood trauma up to the age of 16 (psychological, physical, and sexual abuse, emotional neglect, and bullying) was assessed by using the Childhood Trauma and Abuse Scale. Multiple domains of cognition were measured at baseline and at the time of psychosis conversion, using standardized assessments. In the CHR group, there was a trend for better performance in individuals who reported a history of multiple types of childhood trauma compared with those with no/one type of trauma (Cohen d = 0.16). A history of multiple trauma types was not associated with greater cognitive change in CHR converters over time. Our findings tentatively suggest there may be different mechanisms that lead to CHR states. Individuals who are at clinical high risk who have experienced multiple types of childhood trauma may have more typically developing premorbid cognitive functioning than those who reported minimal trauma do. Further research is needed to unravel the complexity of factors underlying the development of at-risk states.

Keywords

clinical high riskchildhood traumanonsocial cognitionpsychosissocial cognition
Type
Regular Articles
Information
Development and Psychopathology , Volume 33 , Issue 1 , February 2021 , pp. 53 - 64
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Copyright
Copyright © Cambridge University Press 2020

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References

Aas, M., Dazzan, P., Fisher, H. L., Morgan, C., Morgan, K., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P.B., & Pariante, C. M. (2011). Childhood trauma and cognitive function in first-episode affective and non-affective psychosis. Schizophrenia Research, 129, 12–19. doi:10.1016/j.schres.2011.03.017CrossRefGoogle ScholarPubMed
Addington, J., Cadenhead, K. S., Cornblatt, B. A., Mathalon, D. H., McGlashan, T. H., Perkins, , … Cannon, T. D. (2012). North American Prodrome Longitudinal Study (NAPLS 2): Overview and recruitment. Schizophrenia Research, 142, 77–82. doi:10.1016/j.schres.2012.09.012CrossRefGoogle ScholarPubMed
Addington, J., Liu, L., Buchy, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., … McGlashan, T. H. (2015). North American Prodrome Longitudinal Study (NAPLS 2): The prodromal symptoms. Journal of Nervous and Mental Disease, 203, 328–335. doi:10.1097/NMD.0000000000000290CrossRefGoogle ScholarPubMed
Addington, J., Stowkowy, J., Cadenhead, K. S., Cornblatt, B. A., McGlashan, T. H., Perkins, D., … Cannon, T. D. (2013). Early traumatic experiences in those at clinical high risk for psychosis. Early Intervention in Psychiatry, 7, 300–305. doi:10.1111/eip.12020CrossRefGoogle ScholarPubMed
Agnew-Blais, J., & Seidman, L. J. (2013). Neurocognition in youth and young adults under age 30 at familial risk for schizophrenia: A quantitative and qualitative review. Cognitive Neuropsychiatry, 18, 44–82. doi:10.1080/13546805.2012.676309CrossRefGoogle Scholar
Arseneault, L., Cannon, M., Fisher, H. L., Polanczyk, G., Moffitt, T. E., & Caspi, A. (2011). Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study. American Journal of Psychiatry, 168, 65–72. doi:10.1176/appi.ajp.2010.10040567CrossRefGoogle ScholarPubMed
Barbato, M., Colijn, M. A., Keefe, R. S., Perkins, D. O., Woods, S. W., Hawkins, K. A., … Addington, J. (2013). The course of cognitive functioning over six months in individuals at clinical high risk for psychosis. Psychiatry Research, 206, 195–199. doi:10.1016/j.psychres.2012.10.013CrossRefGoogle ScholarPubMed
Barbato, M., Liu, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., … Addington, J. (2015). Theory of mind, emotion recognition and social perception in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophrenia Research: Cognition, 2, 133–139. doi:10.1016/j.scog.2015.04.004CrossRefGoogle ScholarPubMed
Beers, S. R., & De Bellis, M. D. (2002). Neuropsychological function in children with maltreatment-related posttraumatic stress disorder. American Journal of Psychiatry, 159, 483–486. doi:10.1176/appi.ajp.159.3.483CrossRefGoogle ScholarPubMed
Bendall, S., Jackson, H. J., Hulbert, C. A., & McGorry, P. D. (2008). Childhood trauma and psychotic disorders: A systematic, critical review of the evidence. Schizophrenia Bulletin, 34, 568–579. doi:10.1093/schbul/sbm121CrossRefGoogle Scholar
Benedict, R. H. B., Schretlen, D., Groninger, L., & Brandt, J. (1998). The Hopkins Verbal Learning Test–Revised: Normative data and analysis of interform and test-retest reliability. Clinical Neuropsychologist, 12, 43–55.CrossRefGoogle Scholar
Benedict, R. H., Schretlen, D., Groninger, L., Dobraski, M., Sphritz, B. (1996). Revision of the Brief Visuospatial Memory Test: Studies of normal performance, reliability, and validity. Psychological Assessment, 8, 145–153.CrossRefGoogle Scholar
Bora, E., & Murray, R. M. (2014). Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: Do the cognitive deficits progress over, or after, the onset of psychosis? Schizophrenia Bulletin, 40, 744–755. doi:10.1093/schbul/sbt085CrossRefGoogle ScholarPubMed
Bower, G. H. (1981). Mood and memory. American Psychologist, 36, 129–148.CrossRefGoogle ScholarPubMed
Burchinal, M., Vernon-Feagans, L., Cox, M., & Key Family Life Project, I. (2008). Cumulative social risk, parenting, and infant development in rural low-income communities. Parenting: Science and Practice, 8, 41–69. doi:10.1080/15295190701830672CrossRefGoogle ScholarPubMed
Campbell CB, S., Shannon, S., Hoy, K., Rushe, T., Cooper, S., & Mulholland, C. (2013). The relationship between childhood trauma and neuropsychological functioning in first episode psychosis. Psychosis, 5, 48–59.CrossRefGoogle Scholar
Cannon, M., Caspi, A., Moffitt, T. E., Harrington, H., Taylor, A., Murray, R. M., & Poulton, R. (2002). Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: Results from a longitudinal birth cohort. Archives of General Psychiatry, 59, 449–456.CrossRefGoogle ScholarPubMed
Cannon, T. D., Mednick, S. A., Parnas, J., Schulsinger, F., Praestholm, J., & Vestergaard, A. (1993). Developmental brain abnormalities in the offspring of schizophrenic mothers. I. Contributions of genetic and perinatal factors. Archives of General Psychiatry, 50, 551–564.CrossRefGoogle ScholarPubMed
Corcoran, C., Walker, E., Huot, R., Mittal, V., Tessner, K., Kestler, L., & Malaspina, D. (2003). The stress cascade and schizophrenia: Etiology and onset. Schizophrenia Bulletin, 29, 671–692.CrossRefGoogle ScholarPubMed
Cornblatt, B. A., & Erlenmeyer-Kimling, L. (1985). Global attentional deviance as a marker of risk for schizophrenia: Specificity and predictive validity. Journal of Abnormal Psychology, 94, 470–486.CrossRefGoogle ScholarPubMed
Cornblatt, B., Obuchowski, M., Roberts, S., Pollack, S., & Erlenmeyer-Kimling, L. (1999). Cognitive and behavioral precursors of schizophrenia. Dev Psychopathol, 11, 487–508.CrossRefGoogle ScholarPubMed
Dauvermann, M. R., & Donohoe, G. (2019). The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder—A systematic review. Schizophrenia Research: Cognition, 16, 1–11. doi:10.1016/j.scog.2018.11.001CrossRefGoogle ScholarPubMed
Davis, J., Eyre, H., Jacka, F. N., Dodd, S., Dean, O., McEwen, S., … Berk, M. (2016). A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis. Neuroscience & Biobehavioral Reviews, 65, 185–194. doi:10.1016/j.neubiorev.2016.03.017CrossRefGoogle ScholarPubMed
Ding, Y. H., Xu, X., Wang, Z. Y., Li, H. R., & Wang, W. P. (2014). The relation of infant attachment to attachment and cognitive and behavioural outcomes in early childhood. Early Human Devevelopment, 90, 459–464. doi:10.1016/j.earlhumdev.2014.06.004CrossRefGoogle ScholarPubMed
Dong, M., Anda, R. F., Felitti, V. J., Dube, S. R., Williamson, D. F., Thompson, T. J., … Giles, W. H. (2004). The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction. Child Abuse & Neglect, 28, 771–784. doi:10.1016/j.chiabu.2004.01.008CrossRefGoogle ScholarPubMed
Dozier, M., Stovall-McClough, K. C., & Albus, K. E. (2008). Attachment and psychopathology in adulthood. In Shave, J. C. P. R. (Ed.), Handbook of attachment: Theory, research, and clinical applications (pp. 718–744). New York: Guilford Press.Google Scholar
Finkelhor, D., Ormrod, R.K., Turner, H.A. (2007). Poly-victimization: A neglected component in child victimization. Child Abuse & Neglect, 31, 7–26.CrossRefGoogle ScholarPubMed
First, M. S. R., Gibbon, M., Williams, B., & Williams, J.B.W. (1995). Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition. New York: Biometrics Research Department, New York State Psychiatric Institute.Google Scholar
Fisher, H. L., Craig, T. K., Fearon, P., Morgan, K., Dazzan, P., Lappin, J., Hutchinson, G., … Morgan, C. (2011). Reliability and comparability of psychosis patients’ retrospective reports of childhood abuse. Schizophrenia Bulletin, 37(3), 546–553. doi:10.1093/schbul/sbp103CrossRefGoogle ScholarPubMed
Fisher, H. L., Jones, P. B., Fearon, P., Craig, T. K., Dazzan, P., Morgan, K., Hutchinson, G., … Morgan, C. (2010). The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychological Medicine, 40, 1967–1978. doi:10.1017/S0033291710000231CrossRefGoogle ScholarPubMed
Fiske, A. P. (1991). Structures of social life: The four elementary forms of human relations. New York: Free Press.Google Scholar
Fusar-Poli, P., Bonoldi, I., Yung, A. R., Borgwardt, S., Kempton, M. J., Valmaggia, L., … McGuire, P. (2012). Predicting psychosis: Meta- analysis of transition outcomes in individuals at high clinical risk. Archives of General Psychiatry, 69, 220–229.CrossRefGoogle ScholarPubMed
Fusar-Poli, P., Cappucciati, M., Borgwardt, S., Woods, S. W., Addington, J., Nelson, B., … McGuire, P.K. (2016). Heterogeneity of psychosis risk within individuals at clinical high risk: A meta-analytical stratification. JAMA Psychiatry, 73, 113–120. doi:10.1001/jamapsychiatry.2015.2324CrossRefGoogle ScholarPubMed
Fusar-Poli, P., Deste, G., Smieskova, R., Barlati, S., Yung, A. R., Howes, O., … Borgwardt, S. (2012). Cognitive functioning in prodromal psychosis: A meta-analysis. Archives of General Psychiatry, 69, 562–571. doi:10.1001/archgenpsychiatry.2011.1592CrossRefGoogle ScholarPubMed
Giuliano, A. J., Li, H., Mesholam-Gately, R. I., Sorenson, S. M., Woodberry, K. A., & Seidman, L. J. (2012). Neurocognition in the psychosis risk syndrome: A quantitative and qualitative review. Current Pharmaceutical Design, 18, 399–415.CrossRefGoogle ScholarPubMed
Goghari, V. M., & Sponheim, S. R. (2013). More pronounced deficits in facial emotion recognition for schizophrenia than bipolar disorder. Comprehensive Psychiatry, 54, 388–397. doi:10.1016/j.comppsych.2012.10.012CrossRefGoogle ScholarPubMed
Gold, J. M., Carpenter, C., Randolph, C., Goldberg, T. E., & Weinberger, D. R. (1997). Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Archives of General Psychiatry, 54, 159–165.CrossRefGoogle Scholar
Green, M. F., Bearden, C. E., Cannon, T. D., Fiske, A. P., Hellemann, G. S., Horan, W. P., … Neicherlein, K.H. (2012). Social cognition in schizophrenia, Part 1: Performance across phase of illness. Schizophrenia Bulletin, 38, 854–864. doi:10.1093/schbul/sbq171CrossRefGoogle ScholarPubMed
Gur, R. C., Sara, R., Hagendoorn, M., Marom, O., Hughett, P., Macy, L., … Gur, R. E. (2002). A method for obtaining 3-dimensional facial expressions and its standardization for use in neurocognitive studies. Journal of Neuroscience Methods, 115, 137–143.CrossRefGoogle ScholarPubMed
Hackman, D. A., & Farah, M. J. (2009). Socioeconomic status and the developing brain. Trends in Cognitive Sciences, 13, 65–73. doi:10.1016/j.tics.2008.11.003CrossRefGoogle ScholarPubMed
Harvey, P. D., Walker, E., & Wielgus, M. S. (1986). Psychological markers of vulnerability to schizophrenia: Research and future directions. Progressin Experimental Personality & Psychopathology Research, 14, 231–267.Google ScholarPubMed
Hou, C. L., Xiang, Y. T., Wang, Z. L., Everall, I., Tang, Y., Yang, C., … Jia, F. J. (2016). Cognitive functioning in individuals at ultra-high risk for psychosis, first-degree relatives of patients with psychosis and patients with first-episode schizophrenia. Schizophrenia Research, 174, 71–76. doi:10.1016/j.schres.2016.04.034CrossRefGoogle ScholarPubMed
Howe, M. L., & Courage, M. L. (1993). On resolving the enigma of infantile amnesia. Psychological Bulletin, 113, 305–326.CrossRefGoogle ScholarPubMed
Howes, O. D., McCutcheon, R., Owen, M. J., & Murray, R. M. (2017). The role of genes, stress, and dopamine in the development of schizophrenia. Biolological Psychiatry, 81, 9–20. doi:10.1016/j.biopsych.2016.07.014CrossRefGoogle ScholarPubMed
Janssen, I., Krabbendam, L., Bak, M., Hanssen, M., Vollebergh, W., de Graaf, R., & van Os, J. (2004). Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatrica Scandinavica, 109, 38–45.CrossRefGoogle ScholarPubMed
Keefe, R. S., Goldberg, T. E., Harvey, P. D., Gold, J. M., Poe, M. P., & Coughenour, L. (2004). The Brief Assessment of Cognition in Schizophrenia: Reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophrenia Research, 68, 283–297. doi:10.1016/j.schres.2003.09.011CrossRefGoogle ScholarPubMed
Kelleher, I., Clarke, M. C., Rawdon, C., Murphy, J., & Cannon, M. (2013). Neurocognition in the extended psychosis phenotype: Performance of a community sample of adolescents with psychotic symptoms on the MATRICS neurocognitive battery. Schizophrenia Bulletin, 39, 1018–1026. doi:10.1093/schbul/sbs086CrossRefGoogle ScholarPubMed
Kelleher, I., Keeley, H., Corcoran, P., Ramsay, H., Wasserman, C., Carli, V., … Cannon, M. (2013). Childhood trauma and psychosis in a prospective cohort study: Cause, effect, and directionality. American Journal of Psychiatry, 170, 734–741. doi:10.1176/appi.ajp.2012.12091169CrossRefGoogle Scholar
Kern, R. S., Green, M. F., Fiske, A. P., Kee, K. S., Lee, J., Sergi, M. J., … Nuechterlein, K. H. (2009). Theory of mind deficits for processing counterfactual information in persons with chronic schizophrenia. Psychological Medicine, 39, 645–654. doi:10.1017/S0033291708003966CrossRefGoogle ScholarPubMed
Kessler, R. C., McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. … Williams, D. R. (2010). Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. British Journal of Psychiatry, 197, 378–385. doi:10.1192/bjp.bp.110.080499CrossRefGoogle ScholarPubMed
Koenen, K. C., Moffitt, T. E., Caspi, A., Taylor, A., & Purcell, S. (2003). Domestic violence is associated with environmental suppression of IQ in young children. Development and Psychopathology, 15, 297–311.CrossRefGoogle ScholarPubMed
Kohler, C. G., Bilker, W., Hagendoorn, M., Gur, R. E., & Gur, R. C. (2000). Emotion recognition deficit in schizophrenia: Association with symptomatology and cognition. Biological Psychiatry, 48, 127–136.CrossRefGoogle ScholarPubMed
Kohler, C. G., Richard, J. A., Brensinger, C. M., Borgmann-Winter, K. E., Conroy, C. G., Moberg, P. J., … Calkins, M. E. (2014). Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis. Psychiatry Researchearch, 216, 206–212. doi:10.1016/j.psychres.2014.01.023CrossRefGoogle ScholarPubMed
Kraan, T., Velthorst, E., Smit, F., de Haan, L., & van der Gaag, M. (2015). Trauma and recent life events in individuals at ultra high risk for psychosis: Review and meta-analysis. Schizophrenia Research, 161, 143–149. doi:10.1016/j.schres.2014.11.026CrossRefGoogle ScholarPubMed
Lysaker, P.H., Gumley, A., Brune, M., Vanheule, S., Buck, K.D., Dimaggio, G. (2011). Deficits in the ability to recognize one's own affects and those of others: Associations with neurocognition, symptoms and sexual trauma amog persons with schizophrenia spectrum disorders. Consciousness and Cognition, 20, 1183–1192.CrossRefGoogle Scholar
Malarbi, S., Abu-Rayya, H.M., Muscara, F., Stargatt, R. (2017). Neuropsychological functioning of childhood trauma and post-traumatic stress disorder: A meta-analysis. Neuroscience & Biobehavioral Reviews, 72, 68–86.CrossRefGoogle ScholarPubMed
Matheson, S. L., Shepherd, A. M., Pinchbeck, R. M., Laurens, K. R., & Carr, V. J. (2013). Childhood adversity in schizophrenia: A systematic meta-analysis. Psychological Medicine, 43, 225–238. doi:10.1017/S0033291712000785CrossRefGoogle ScholarPubMed
McDonald, S., Flanagan, S., Rollins, J., & Kinch, J. (2003). TASIT: A new clinical tool for assessing social perception after traumatic brain injury. Journal of Head Trauma Rehabilitation, 18, 219–238.CrossRefGoogle ScholarPubMed
McGlashan T, W. B., Woods, SW. (2010). The Psychosis Risk Syndrome: Handbook for Diagnosis and Follow-up. New York: Oxford University Press.Google Scholar
Mezzacappa, E., Kindlon, D., & Earls, F. (2001). Child abuse and performance task assessments of executive functions in boys. Journal of Child Psychology and Psychiatry, 42, 1041–1048.CrossRefGoogle ScholarPubMed
Miller, T. J., McGlashan, T. H., Rosen, J. L., Cadenhead, K., Cannon, T., Ventura, J., … Woods, S.W. (2003). Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: Predictive validity, interrater reliability, and training to reliability. Schizophrenia Bulletin, 29, 703–715.CrossRefGoogle ScholarPubMed
Miller, T.J., McGlashan, T.H., Rosen, J.L., Somjee, L., Markovich, P.J., Stein, K., & Woods, S.W. (2002). Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: Preliminary evidence of interrater reliability and predictive validity. American Journal of Psychiatry, 159, 863–865.CrossRefGoogle ScholarPubMed
Morgan, C., & Fisher, H. (2007). Environment and schizophrenia: Environmental factors in schizophrenia: Childhood trauma—A critical review. Schizophrenia Bulletin, 33, 3–10. doi:10.1093/schbul/sbl053CrossRefGoogle ScholarPubMed
Myin-Germeys, I., Krabbendam, L., Jolles, J., Delespaul, P. A., & van Os, J. (2002). Are cognitive impairments associated with sensitivity to stress in schizophrenia? An experience sampling study. American Journal of Psychiatry, 159, 443–449. doi:10.1176/appi.ajp.159.3.443CrossRefGoogle ScholarPubMed
Myin-Germeys, I., & van Os, J. (2007). Stress-reactivity in psychosis: Evidence for an affective pathway to psychosis. Clinical Psychology Review, 27, 409–424. doi:10.1016/j.cpr.2006.09.005CrossRefGoogle ScholarPubMed
Navalta, C. P., Polcari, A., Webster, D. M., Boghossian, A., & Teicher, M. H. (2006). Effects of childhood sexual abuse on neuropsychological and cognitive function in college women. Journal of Neuropsychiatry and Clinical Neurosciences, 18, 45–53. doi:10.1176/jnp.18.1.45CrossRefGoogle ScholarPubMed
Nuechterlein, K., & Dawson, M. E. (1984). A heuristic vulnerability-stress model of schizophrenia. Schizophrenia Bulletin, 10, 300–312.CrossRefGoogle Scholar
Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., … Marder, S. R. (2008). The MATRICS Consensus Cognitive Battery, Part 1: Test selection, reliability, and validity. American Journal of Psychiatry, 165, 203–213. doi:10.1176/appi.ajp.2007.07010042CrossRefGoogle ScholarPubMed
Piskulic, D., Liu, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D.O., … Addington, J. (2016). Social cognition over time in individuals at clinical high risk for psychosis: Findings from the NAPLS-2 cohort. Schizophrenia Research, 171, 176–181. doi:10.1016/j.schres.2016.01.017CrossRefGoogle ScholarPubMed
Radua, J., Ramella-Cravaro, V., Ioannidis, J. P. A., Reichenberg, A., Phiphopthatsanee, N., Amir, T., … Fusar-Poli, P. (2018). What causes psychosis? An umbrella review of risk and protective factors. World Psychiatry, 17, 49–66. doi:10.1002/wps.20490CrossRefGoogle ScholarPubMed
Read, J., Perry, B. D., Moskowitz, A., & Connolly, J. (2001). The contribution of early traumatic events to schizophrenia in some patients: A traumagenic neurodevelopmental model. Psychiatry, 64, 319–345.CrossRefGoogle ScholarPubMed
Reichenberg, A., Caspi, A., Harrington, H., Houts, R., Keefe, R. S., Murray, R. M., … Moffitt, T. E. (2010). Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: A 30-year study. American Journal of Psychiatry, 167, 160–169. doi:10.1176/appi.ajp.2009.09040574CrossRefGoogle ScholarPubMed
Reitan Neuropsychology Laboratory (1944). Army Individual Test Battery, Manual of Directions and Scoring. Washington, DC: War Department, Adjunct General's Office.Google Scholar
Rokita, K. I., Dauvermann, M. R., & Donohoe, G. (2018). Early life experiences and social cognition in major psychiatric disorders: A systematic review. European Psychiatry, 53, 123–133. doi:10.1016/j.eurpsy.2018.06.006CrossRefGoogle ScholarPubMed
Schacter, D. L. (1999). The seven sins of memory. Insights from psychology and cognitive neuroscience. American Psychologist, 54, 182–203.CrossRefGoogle ScholarPubMed
Seidman, L. J., Giuliano, A. J., Meyer, E. C., Addington, J., Cadenhead, K. S., Cannon, T. D., McGlashan, T.H., … North American Prodrome Longitudinal Study, G. (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: Relationship to family history and conversion to psychosis. Archives of General Psychiatry, 67, 578–588. doi:10.1001/archgenpsychiatry.2010.66CrossRefGoogle ScholarPubMed
Seidman, L. J., Shapiro, D. I., Stone, W. S., Woodberry, K. A., Ronzio, A., Cornblatt, B. A., … Woods, S. W. (2016). Association of neurocognition with transition to psychosis: Baseline functioning in the second phase of the North American Prodrome Longitudinal Study. JAMA Psychiatry, 73, 1239–1248. doi:10.1001/jamapsychiatry.2016.2479CrossRefGoogle ScholarPubMed
Sergi, M. J., Fiske, A. P., Horan, W. P., Kern, R. S., Kee, K. S., Subotnik, K. L., … Green, M. F. (2009). Development of a measure of relationship perception in schizophrenia. Psychiatry Research, 166, 54–62. doi:10.1016/j.psychres.2008.03.010CrossRefGoogle Scholar
Snitz, B. E., Macdonald, A. W., & Carter, C. S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32, 179–194. doi:10.1093/schbul/sbi048CrossRefGoogle ScholarPubMed
Sparks, A., McDonald, S., Lino, B., O'Donnell, M., & Green, M. J. (2010). Social cognition, empathy and functional outcome in schizophrenia. Schizophrenia Research, 122, 172–178. doi:10.1016/j.schres.2010.06.011CrossRefGoogle Scholar
Spreen, O. and Strauss, E. (1998) A compendium of neuropsychological tests: Administration, norms, and commentary (2nd Edition). New York: Oxford University Press.Google Scholar
StataCorp. (2017). Stata Statistical Software: Release 15. In. College Station, Texas: StataCorp LLC.Google Scholar
Stern, R. A., & White, T. (2003). Neuropsychological Assessment Battery. Lutz, FL: Psychological Assessment Resources.Google Scholar
Stowkowy, J., Liu, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., … Addington, J. (2016). Early traumatic experiences, perceived discrimination and conversion to psychosis in those at clinical high risk for psychosis. Social Psychiatry and Psychiatric Epidemiology, 51, 497–503. doi:10.1007/s00127-016-1182-yCrossRefGoogle ScholarPubMed
Thompson, A. D., Bartholomeusz, C., & Yung, A. R. (2011). Social cognition deficits and the “ultra high risk” for psychosis population: A review of literature. Early Intervention in Psychiatry, 5, 192–202. doi:10.1111/j.1751-7893.2011.00275.xGoogle Scholar
Thompson, A.D., Nelson, B., Yuen, H.P., Lin, A., Amminger, G.P., McGorry, P.D., … Yung, A.R. (2014). Sexual trauma increases the risk of developing psychosis in an ultra high-risk “prodromal” population. Schizophrenia Bulletin, 40, 697–706.CrossRefGoogle Scholar
Tienari, P., Wynne, L. C., Moring, J., Lahti, I., Naarala, M., Sorri, A., … Laksy, K. (1994). The Finnish adoptive family study of schizophrenia. Implications for family research. British Journal of Psychiatry Supplement, 23, 20–26.CrossRefGoogle Scholar
Tikka, M., Luutonen, S., Ilonen, T., Tuominen, L., Kotimaki, M., Hankala, J., & Salokangas, R. K. (2013). Childhood trauma and premorbid adjustment among individuals at clinical high risk for psychosis and normal control subjects. Early Intervention in Psychiatry, 7, 51–57. doi:10.1111/j.1751-7893.2012.00391.xCrossRefGoogle ScholarPubMed
Trauelsen, A.M., Gumley, A., Jansen, J.E., Pedersen, M.B., Nielsen, H.G.L., Haahr, U.H., & Simonsen, E. (2019) Does childhood trauma predict poorer metacognitive abilities in people withfirst-episode psychosis? Psychiatry Research, 273, 163–170.CrossRefGoogle ScholarPubMed
Trotta, A., Murray, R. M., & Fisher, H. L. (2015). The impact of childhood adversity on the persistence of psychotic symptoms: A systematic review and meta-analysis. Psychological Medicine, 45, 2481–2498. doi:10.1017/S0033291715000574CrossRefGoogle ScholarPubMed
Turner, H.A., Finkelhor, D., & Ormrod, R. (2010). Poly-victimization in a national sample of children and youth. American Journal of Preventive Medicine, 38, 323–330.CrossRefGoogle Scholar
Ucok, A., Kaya, H., Ugurpala, C., Cikrikcili, U., Ergul, C., Yokusoglu, C., … Direk, N. (2015). History of childhood physical trauma is related to cognitive decline in individuals with ultra-high risk for psychosis. Schizophrenia Research, 169, 199–203. doi:10.1016/j.schres.2015.08.038CrossRefGoogle ScholarPubMed
van Dam, D. S., van der Ven, E., Velthorst, E., Selten, J. P., Morgan, C., & de Haan, L. (2012). Childhood bullying and the association with psychosis in non-clinical and clinical samples: A review and meta-analysis. Psychological Medicine, 42, 2463–2474. doi:10.1017/S0033291712000360CrossRefGoogle ScholarPubMed
van Os, J., Marsman, A., van Dam, D., Simons, C.J.; & GROUP Investigators (2017). Evidence that the impact of childhood trauma on IQ is substantial in controls, moderate in siblings, and absent in patients with psychotic disorder. Schizophrenia Bulletin, 43, 316–324.CrossRefGoogle ScholarPubMed
Varese, F., Smeets, F., Drukker, M., Lieverse, R., Lataster, T., Viechtbauer, W., … Bentall, R. P. (2012). Childhood adversities increase the risk of psychosis: A meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophrenia Bulletin, 38, 661–671. doi:10.1093/schbul/sbs050CrossRefGoogle ScholarPubMed
Vargas, T., Lam, P.H., Azis, M., Osborne, K.J., Lieberman, A., & Mittal, V.A. (2019). Childhood trauma and neurocognition in adults with psychotic disorders: A systematic review and meta-analysis. Schizophrenia Bulletin, 45, 1195–1208. doi:10.1093/schbul/sby150CrossRefGoogle ScholarPubMed
Velikonja, T., Fisher, H. L., Mason, O., & Johnson, S. (2015). Childhood trauma and schizotypy: A systematic literature review. Psychological Medicine, 45, 947–963. doi:10.1017/S0033291714002086CrossRefGoogle ScholarPubMed
Velikonja, T., Velthorst, E, McClure, M. M., Rutter, S., Calabrese, W., Rosell, D.; Koenigsberg, H. W., Goodman, M., … Perez-Rodriguez, M. M. (2019). Severe childhood trauma and clinical and neurocognitive features in schizotypal personality disorder. Acta Psychiatrica Scandinavica, 140, 50–64.CrossRefGoogle ScholarPubMed
Velthorst, E., Nelson, B., O'Connor, K., Mossaheb, N., de Haan, L., Bruxner, A., … Thompson, A. (2013). History of trauma and the association with baseline symptoms in an ultra-high risk for psychosis cohort. Psychiatry Researchearch, 210, 75–81. doi:10.1016/j.psychres.2013.06.007CrossRefGoogle Scholar
Walker, E. F., & Diforio, D. (1997). Schizophrenia: A neural diathesis-stress model. Psychological Review, 104, 667–685.CrossRefGoogle ScholarPubMed
Wechsler, D. (1997). Wechsler Adult Intelligence Scale. San Antonio, TX: Psychological Corporation.Google Scholar
Weinberger, D. R. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44(7), 660–669.CrossRefGoogle ScholarPubMed
Widom, C. S., Czaja, S. J., & Dutton, M. A. (2008). Childhood victimization and lifetime revictimization. Child Abuse & Neglect, 32, 785–796. doi:10.1016/j.chiabu.2007.12.006CrossRefGoogle ScholarPubMed
Zubin, J., & Spring, B. (1977). Vulnerability: A new view of schizophrenia. Journal of Abnormal Psychology, 86, 103–126.CrossRefGoogle ScholarPubMed
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