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Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood

Published online by Cambridge University Press:  22 July 2015

Salvatore P. Insana ,
Layla Banihashemi ,
Ryan J. Herringa ,
David J. Kolko  and
Anne Germain
Salvatore P. Insana
Affiliation:
University of Pittsburgh School of Medicine
Layla Banihashemi
Affiliation:
University of Pittsburgh School of Medicine
Ryan J. Herringa
Affiliation:
University of Pittsburgh School of Medicine University of Wisconsin School of Medicine and Public Health
David J. Kolko
Affiliation:
University of Pittsburgh School of Medicine
Anne Germain*
Affiliation:
University of Pittsburgh School of Medicine
*
Address correspondence and reprint requests to: Anne Germain, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O'Hara Street, Sterling Plaza 239, Pittsburgh, PA 15213; E-mail: [email protected].
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Abstract

Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting–wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal–temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health.

Type
Regular Articles
Information
Development and Psychopathology , Volume 28 , Issue 2 , May 2016 , pp. 551 - 564
Copyright
Copyright © Cambridge University Press 2015 

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