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When inflammation and depression go together: The longitudinal effects of parent–child relationships

Published online by Cambridge University Press:  22 November 2017

Steven R. H. Beach ,
Man Kit Lei ,
Ronald L. Simons ,
Ashley B. Barr ,
Leslie G. Simons ,
Katherine Ehrlich ,
Gene H. Brody  and
Robert A. Philibert
Steven R. H. Beach*
Affiliation:
University of Georgia
Man Kit Lei
Affiliation:
University of Georgia
Ronald L. Simons
Affiliation:
University of Georgia
Ashley B. Barr
Affiliation:
State University of New York Buffalo
Leslie G. Simons
Affiliation:
University of Georgia
Katherine Ehrlich
Affiliation:
University of Georgia
Gene H. Brody
Affiliation:
University of Georgia
Robert A. Philibert
Affiliation:
University of Iowa
*
Address correspondence and reprint requests to: Steven R. H. Beach, Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30602-4527; E-mail: [email protected].
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Abstract

Parent–child relationships have long-term effects on health, particularly later inflammation and depression. We hypothesized that these effects would be mediated by later romantic partner relationships and elevated stressors in young adulthood, helping promote chronic, low grade, inflammation as well as depressive symptoms, and driving their covariation. It has been proposed recently that youth experiencing harsher parenting may also develop a stronger association between inflammation and depressive symptoms in adulthood and altered effects of stressors on outcomes. In the current investigation, we test these ideas using an 18-year longitudinal study of N = 413 African American youth that provides assessment of the parent–child relationship (at age 10), pro-inflammatory cytokine profile and depressive symptoms (at age 28), and potential mediators in early young adulthood (assessed at ages 21 and 24). As predicted, the effect of harsher parent–child relationships (age 10) on pro-inflammatory state and increased depressive symptoms at age 28 were fully mediated through young adult stress and romantic partner relationships. In addition, beyond these mediated effects, parent–child relationships at age 10 moderated the concurrent association between inflammation and depressive symptoms, as well as the prospective association between romantic partner relationships and inflammation, and resulted in substantially different patterns of indirect effects from young adult mediators to outcomes. The results support theorizing that the association of depression and inflammation in young adulthood is conditional on earlier parenting, and suggest incorporating this perspective into models predicting long-term health outcomes.

Type
Special Issue Articles
Information
Development and Psychopathology , Volume 29 , Special Issue 5: Biological and Behavioral Effects of Early Adversity on Multiple Levels of Development , December 2017 , pp. 1969 - 1986
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

This research was supported by Award Number R01 HL8045 from the National Heart, Lung, and Blood Institute; Award Number R01 HD080749 from the National Institute of Child Health and Human Development; and P30 DA027827 from the National Institute on Drug Abuse. The content is solely the responsibility of the authors and does not necessarily reflect the official views of the National Institutes of Health or any agencies that comprise it.

References

Barr, A. B., Culatta, E., & Simons, R. L. (2013). Romantic relationships and health among African American young adults: Linking patterns of relationship quality over time to changes in physical and mental health. Journal of Health and Social Behavior, 54, 369–385. doi:10.1177/0022146513486652 Google Scholar
Barr, A. B., Sutton, T. E., Simons, L. G., Wickrama, K. A. S., & Lorenz, F. O. (2016). Romantic relationship transitions and changes in health among rural, White young adults. Journal of Family Psychology, 30, 832–842. doi:10.1037/fam0000207 CrossRefGoogle ScholarPubMed
Beach, S. R. H. (2014). The couple and family discord model of depression: Updates and future directions. In Agnew, C. R. & South, S. C. (Eds.), Interpersonal relationships and health: Social and clinical psychological mechanisms (pp. 133–155). New York: Oxford University Press.Google Scholar
Beach, S. R. H., Lei, M. K., Brody, G. H., Dogan, M. V., & Philibert, R. A. (2015). Higher levels of protective parenting are associated with better young adult health: Exploration of mediation through epigenetic influences on pro-inflammatory processes. Frontiers in Psychology, 6, 676. doi:10.3389/fpsyg.2015.00676 CrossRefGoogle ScholarPubMed
Beach, S. R. H., Lei, M. K., Brody, G. H., Kim, S., Barton, A. W., Dogan, M. V., & Philibert, R. A. (2016). Parenting, SES-risk, and later young adult health: Exploration of opposing indirect effects via DNA methylation. Child Development, 87, 111–121. doi:10.1111/cdev.12486 CrossRefGoogle ScholarPubMed
Beach, S. R. H., Lei, M. K., Brody, G. H., Miller, G. E., Chen, E., Mandara, J., & Philibert, R. A. (2016). Smoking in young adulthood among African Americans: Interconnected effects of supportive parenting in early adolescence, pro-inflammatory epitype, and young adult stress. Development and Psychopathology. Advance online publication. doi:10.1017/S0954579416000961 Google Scholar
Beach, S. R. H., Sandeen, E. E., & O'Leary, K. D. (1990). Depression in marriage: A model for etiology and treatment. New York: Guilford Press.Google Scholar
Bentler, P. M. (1990). Comparative fit indexes in structural models. Psychological Bulletin, 107, 238–246.CrossRefGoogle ScholarPubMed
Blatt, S. J., & Homann, E. (1992). Parent-child interaction in the etiology of dependent and self-critical depression. Clinical Psychology Review, 12, 47–91.Google Scholar
Brody, G. H., Chen, Y.-F., Murry, V. M., Simons, R. L., Ge, X., Gibbons, F. X., … Cutrona, C. E. (2006). Perceived discrimination and the adjustment of African American youths: A five-year longitudinal analysis with contextual moderation effects. Child Development, 77, 1170–1189.Google Scholar
Brody, G. H., Miller, G. E., Yu, T., Beach, S. R. H., & Chen, E. (2016). Supportive family environments ameliorate the link between racial discrimination and epigenetic aging: A replication across two longitudinal cohorts. Psychological Science, 27, 530–541. doi:10.1177/0956797615626703 CrossRefGoogle ScholarPubMed
Brody, G. H., Yu, T., & Beach, S. R. H. (2016). Resilience to adversity and the early origins of disease. Development and Psychopathology, 28, 1347–1365. doi:10.1017/S0954579416000894 CrossRefGoogle ScholarPubMed
Brody, G. H., Yu, T., Beach, S. R. H., Kogan, S. M., Windle, M., & Philibert, R. A. (2014). Harsh parenting and adolescent health: A longitudinal analysis with genetic moderation. Health Psychology, 33, 401–409. doi:10.1037/a0032686 Google Scholar
Brody, G. H., Yu, T., Miller, G. E., & Chen, C. (2015). Discrimination, racial identity, and cytokine levels among African-American adolescents. Journal of Adolescent Health, 56, 496–501.Google Scholar
Brown, G. W., & Harris, T. O. (1989). Social origins of depression: A study of psychiatric disorder in women. London: Routledge.Google Scholar
Browne, M. W., & Cudeck, R. (1992). Alternative ways of assessing model fit. Sociological Methods and Research, 21, 230–258.CrossRefGoogle Scholar
Bryant, C. M. (2006). Pathways linking early experiences and later relationship functioning. In Crouter, A. C. & Booth, A. (Eds.), Romance and sex in adolescence and emerging adulthood: Risks and opportunities (pp. 103–111). Mahwah, NJ: Erlbaum.Google Scholar
Chen, E., & Miller, G. E. (2013). Socioeconomic status and health: Mediating and moderating factors. Annual Review of Clinical Psychology, 9, 723–749.CrossRefGoogle ScholarPubMed
Chou, T., Asnaani, A., & Hofmann, S. G. (2012). Perception of racial discrimination and psychopathology across three U.S. ethnic minority groups. Cultural Diversity and Ethnic Minority Psychology, 18, 74–81. doi:10.1037/a0025432 Google Scholar
Cicchetti, D., & Toth, S. L. (2005). Child maltreatment. Annual Review of Clinical Psychology, 1, 409–438.Google Scholar
Cole, S. W. (2013). Social regulation of human gene expression: Mechanisms and implications for public health. American Journal of Public Health, 103(Suppl. 1), S84–S92. doi:10.2105/AJPH.2012.301183 Google Scholar
Cole, S. W., Conti, G., Arevalo, J. M. G., Ruggiero, A. M., Heckman, J. J., & Suomi, S. J. (2012). Transcriptional modulation of the developing immune system by early life social adversity. Proceedings of the National Academy of Sciences, 109, 20578–20583. doi:10.1073/pnas.1218253109 Google Scholar
Conger, R. D., Conger, K. J., Elder, G. H., Lorenz, F. O., Simons, R. L., & Whitbeck, L. B. (1992). A family process model of economic hardship and adjustment of early adolescent boys. Child Development, 63, 526–541.Google Scholar
Conger, R. D., Conger, K. J., & Marin, M. J. (2010). Socioeconomic status, family processes, and individual development. Journal of Marriage and Family, 72, 685–704.Google Scholar
Conger, R. D., Cui, M., Bryant, G. M., & Elder, G. H. (2000). Competence in early adult romantic relationships. Journal of Personality and Social Psychology, 79, 224–237. doi:10.1037/0022-3514.79.2.224 Google Scholar
Conger, R. D., & Elder, G. H. Jr. (1994). Families in troubled times: The Iowa Youth and Families Project. In Conger, R. D. & Elder, G. H. Jr., (Eds.), Families in troubled times: Adapting to change in rural America (pp. 57–78). Hawthorne, NY: Aldine de Gruyter.Google Scholar
Conraads, V. M., Denollet, J., De Clerck, L. S., Stevens, W. J., Bridts, C., & Vrints, C. J. (2006). Type D personality is associated with increased levels of tumour necrosis factor (TNF)-α and TNF-α receptors in chronic heart failure. International Journal of Cardiology, 113, 34–38.Google Scholar
Cui, M., Lorenz, F., Conger, R., Melby, J., & Bryant, C. (2005). Observer, self-, and partner reports of hostile behaviors in romantic relationships. Journal of Marriage and Family, 67, 1169–1181. doi:10.1111/j.1741-3737.2005.00208.x CrossRefGoogle Scholar
Cutrona, C. E., Abraham, W. T., Russel, D. W., Beach, S. R. H., Burzette, R., Gibbons, F. X., … Philibert, R. A. (2015). Financial strain, inflammatory factors, and hemoglobin A1C levels in African-American women. British Journal of Health Psychology, 20, 662–679. doi:10.1111/bjhp.12120 CrossRefGoogle ScholarPubMed
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry, 65, 409–415.Google Scholar
Dube, S. R., Fairweather, D., Pearson, W. S., Felitti, V. J., Anda, R. F., & Croft, J. B. (2009). Cumulative childhood stress and autoimmune diseases in adults. Psychosomatic Medicine, 71, 243–250.CrossRefGoogle ScholarPubMed
Eberhart, N., & Hammen, C. (2006). Interpersonal predictors of onset of depression during the transition to adulthood. Personal Relationships, 13, 195–206.CrossRefGoogle Scholar
Ehrlich, K. B., Miller, G. E., Rohleder, N., & Adam, E. K. (2015). Trajectories of relationship stress and inflammatory processes in adolescence. Development and Psychopathology, 28, 127–138. doi:10.1017/S0954579415000334 Google Scholar
Elenkov, I. J., & Chrousos, G. P. (2002). Stress hormones, proinflammatory and anti-inflammatory cytokines, and autoimmunity. Annals of the New York Academy of Sciences, 966, 290–303.CrossRefGoogle Scholar
Espejo, E., Hammen, C., Connolly, N., Brennan, P., Najman, J., & Bor, W. (2007). Stress sensitization and adolescent depressive severity as a function of childhood adversity: A link to anxiety disorders. Journal of Abnormal Child Psychology, 35, 287–299.Google Scholar
Flinn, M. V., & England, B. G. (1995). Childhood stress and family environment. Current Anthropology, 36, 854–866. doi:10.1086/204444 Google Scholar
Furstenberg, F. F. (2008). The intersections of social class and the transition to adulthood. New Directions for Child and Adolescent Development, 2008, 1–10.Google Scholar
Geronimus, A. T., Hicken, M., Keene, D., & Bound, J. (2006). “Weathering” and age patterns of allostatic load scores among Blacks and Whites in the United States. American Journal of Public Health, 96, 826–833. doi:10.2105/ajph.2004.060749 CrossRefGoogle ScholarPubMed
Geronimus, A. T., Hicken, M. T., Pearson, J. A., Seashols, S. J., Brown, K. L., & Cruz, T. D. (2010). Do US Black women experience stress-related accelerated biological aging? A novel theory and first population-based test of Black-White differences in telomere length. Human Nature, 21, 19–38. doi:10.1007/s12110-010-9078-0 Google Scholar
Gibbons, F. X., Gerrard, M., Cleveland, M. J., Wills, T. A., & Brody, G. (2004). Perceived discrimination and substance use in African American parents and their children: A panel study. Journal of Personality and Social Psychology, 86, 517–529. doi:10.1037/0022-3514.86.4.517 Google Scholar
Gibbons, F. X., Kingsbury, J. H., Weng, C., Gerrard, M., Cutrona, C., Willa, T. A., & Stock, M. (2014). Effects of perceived racial discrimination on health status and health behavior: A differential mediation hypothesis. Health Psychology, 33, 11–19. doi:10.1037/a0033857 Google Scholar
Glassman, A. H., & Miller, G. E. (2007). Where there is depression, there is inflammation. Sometimes! Biological Psychiatry, 62, 280–281.Google Scholar
Gluckman, P. D., Hanson, M. A., & Spencer, H. G. (2005). Predictive adaptive responses and human evolution. Trends in Ecology and Evolution, 20, 537–533.Google Scholar
Hammen, C. (2006). Stress generation in depression: Reflections on origins, research, and future directions. Journal of Clinical Psychology, 62, 1065–1082. doi:10.1002/JCLP.20293 CrossRefGoogle ScholarPubMed
Hepgul, N., Cattaneo, A., Agarwal, K., Baraldi, S., Borsini, A., Bufalino, C., … Pariante, C. M. (2016). Transcriptomics in interferon-α-treated patients identifies inflammation-, neuroplasticity- and oxidative stress-related signatures as predictors and correlates of depression. Neuropsychopharmacology, 41, 2502–2511. doi:10.1038/npp.2016.50 Google Scholar
Hertzman, C. (2012). Putting the concept of biological embedding in historical perspective. Proceedings of the National Academy of Sciences, 109(Suppl. 2), 17160–17167. doi:10.1073/pnas.1202203109 Google Scholar
Irwin, M. R., & Cole, S. W. (2011). Reciprocal regulation of the neural and innate immune systems. Nature Reviews Immunology, 11, 625–632.Google Scholar
Kessler, R. C., & Mroczek, D. (1994). Scoring of the UM CIDI short forms. Ann Arbor, MI: University of Michigan, Institute for Social Research.Google Scholar
Kiecolt-Glaser, J. K., Gouin, J., & Hantsoo, L. (2010). Close relationships, inflammation, and health. Neuroscience & Biobehavioral Reviews, 35, 33–38. doi:10.1016/j.neubiorev.2009.09.003 Google Scholar
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Leme-show, S., Dickinson, S. L., & Glaser, R. (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62, 1377–1384. doi:10.1001/archpsyc.62.12.1377 Google Scholar
Kohen, D. E., Brooks-Gunn, J., Leventhal, T., & Hertzman, C. (2002). Neighborhood income and physical and social disorder in Canada: Associations with young children's competencies. Child Development, 73, 1844–1860.Google Scholar
Landrine, H., & Klonoff, E. A. (1996). The Schedule of Racist Events: A measure of racial discrimination and a study of its negative physical and mental health consequences. Journal of Black Psychology, 22, 144–168. doi:10.1177/00957984960222002 Google Scholar
Luthar, S. S. (2006). Resilience in development: A synthesis of research across five decades. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology: Risk, disorder, and adaptation (pp. 740–795). Hoboken, NJ: Wiley.Google Scholar
Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009). Glucocorticoid dysregulations and their clinical correlates: From receptors to therapeutics. Annals of the New York Academy of Sciences, 1179, 1–18. doi:10.1111/j.1749-6632.2009.04987.x Google Scholar
McEwen, B. S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338, 171–179.Google Scholar
McLoyd, V. C. (1990). The impact of economic hardship on Black families and children: Psychological distress, parenting, and socioemotional development. Child Development, 61, 311–346. doi:10.1111/j.1467-8624.1990.tb02781.x CrossRefGoogle ScholarPubMed
Miller, A. H., Maletic, V., & Raison, C. L. (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65, 732–741. doi:10.1016/j.biopsych.2008.11.029 Google Scholar
Miller, G. E., & Chen, E. (2010). Harsh family climate in early life presages the emergence of pro-inflammatory phenotype in adolescence. Psychological Science, 21, 848–856.Google Scholar
Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959–997.Google Scholar
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., … Cole, S. W. (2008). A genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-kB signaling. Biological Psychiatry, 64, 266–272 doi:10.1016/j.biopsych.2008.03.017 CrossRefGoogle Scholar
Miller, G. E., & Cole, S. W. (2012). Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biological Psychiatry, 72, 34–40. doi:10.1016/j.biopsych.2012.02.034 Google Scholar
Miller, G. E., Lachman, M. E., Chen, E., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2011). Pathways to resilience: Maternal nurturance as a buffer against the effects of childhood poverty on metabolic syndrome at midlife. Psychological Science, 22, 1591–1599.Google Scholar
Mirowsky, J. (1999). Analyzing associations between mental health and social circumstances. In Aneshensel, C. S. & Phelan, J. C. (Eds.), Handbook of the sociology of mental health (pp. 105–123). New York: Plenum Press.Google Scholar
Moffitt, T. E., & Klaus-Grawe 2012 Think Tank (2013). Childhood exposure to violence and lifelong health: Clinical intervention science and stress biology research join forces. Development and Psychopathology, 25, 1619–1634. doi:10.1017/S0954579413000801 Google Scholar
Muthen, L. K., & Muthen, B. O. (2015). Mplus version 7/04: Base program and combination add-on. Los Angeles: Authors.Google Scholar
Nunnally, J. C. (1978). Psychometric theory. New York: McGraw-Hill.Google Scholar
Osgood, D. W., Foster, E. M., Flanagan, C., & Ruth, G. R. (Eds.). (2005). On your own without a net: The transition to adulthood for vulnerable populations. Chicago: University of Chicago Press.Google Scholar
Overbeek, G., Vollebergh, W., de Graaf, R., Scholte, R., de Kemp, R., & Engels, R. (2006). Longitudinal associations of marital quality and marital dissolution with the incidence of DSM-III-R disorders. Journal of Family Psychology, 20, 284–291. doi:10.1037/0893-3200.20.2.284 Google Scholar
Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., & Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine, 11, 200. doi:10.1186/1741-7015-11-200 Google Scholar
Pendry, P., & Adam, E. K. (2007). Associations between parents’ marital functioning, maternal parenting quality, maternal emotion and child cortisol levels. International Journal of Behavioral Development, 31, 218–231.Google Scholar
Phelan, J. C., & Link, B. G. (2015). Is racism a fundamental cause of inequalities in health? Annual Review of Sociology, 41, 311–330. doi:10.1146/annurev-soc-073014-112305 Google Scholar
Raison, C. L., Capuron, L., & Miller, A. H. (2006). Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends in Immunology, 27, 24–31.Google Scholar
Raison, C. L., & Miller, A. H. (2003). When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. American Journal of Psychiatry, 160, 1554–1565. doi:10.1176/appi.ajp.160.9.1554 Google Scholar
Rickard, I. J., & Lummaa, V. (2007). The predictive adaptive response and metabolic syndrome: Challenges for the hypothesis. Trends in Endocrinology and Metabolism, 18, 94–99. doi:10.1016/j.tem.2007.02.004 Google Scholar
Rohleder, N., Marin, T. J., Ma, R., & Miller, G. E. (2009). Biologic cost of caring for a cancer patient: Dysregulation of pro- and anti-inflammatory signaling pathways. Journal of Clinical Oncology, 27, 2909–2915. doi:10.1200/JCO.2008.18.7435 Google Scholar
Schofield, T. J., Conger, R. D., Gonzales, J. E., & Merrick, M. T. (2016). Harsh parenting, physical health, and the protective role of positive parent-adolescent relationships. Social Science & Medicine, 157, 18–26. doi:10.1016/j.socscimed.2016.03.027 CrossRefGoogle ScholarPubMed
Simons, L. G., Simons, R. L., Landor, A. M., Bryant, C. M., & Beach, S. R. H. (2014). Factors linking childhood experiences to adult romantic relationships among African Americans. Journal of Family Psychology, 28, 368–379. doi:10.1037/a0036393 Google Scholar
Simons, R. L., Lei, M. K., Beach, S. R. H., Barr, A. B., Simons, L. G., Gibbons, F. X., Philibert, R. A. (2016). Discrimination, segregation, and chronic inflammation: Testing the weathering explanation for the poor health of Black Americans. Unpublished manuscript, University of Georgia.Google Scholar
Simons, R. L., Lei, M. K., Beach, S. R. H., Philibert, R. A., Cutrona, C. E., Gibbons, F. X., & Barr, A. (2016). Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women. Social Science and Medicine, 150, 192–200.CrossRefGoogle Scholar
Simons, R. L., Simons, L. G., & Wallace, L. E. (2004). Families, delinquency and crime: Linking society's most basic institution to antisocial behavior. New York: Oxford University Press.Google Scholar
Slopen, N., Lewis, T. T., Gruenewald, T. L., Mujahid, M. S., Ryff, C. D., Albert, M. A., & Williams, D. R. (2010). Early life adversity and inflammation in African Americans and Whites in the midlife in the United States survey. Psychosomatic Medicine, 72, 694–701. doi:10.1097/PSY.0b013e3181e9c16f CrossRefGoogle ScholarPubMed
Steinberg, S. J., & Davila, J. (2008). Adolescent romantic functioning and depression: The moderating role of parental emotional availability. Journal of Clinical Child and Adolescent Psychology, 37, 350–362.Google Scholar
Stock, M. L., Gibbons, F. X., Peterson, L. M., & Gerrard, M. (2013). The effects of racial discrimination on the HIV-risk cognitions and behaviors of Black adolescents and young adults. Health Psychology, 32, 543.Google Scholar
Surjadi, F. F., Lorenz, F. O., Wickrama, K. A. S., & Conger, R. D. (2011). Parental support, partner support, and the trajectories of mastery from adolescence to early adulthood. Journal of Adolescence, 34, 619–628.Google Scholar
Taylor, B. D., Holzman, C. B., Fichorova, R. N., Tian, Y., Jones, N. M., Fu, W., & Senagore, P. K. (2013). Inflammation biomarkers in vaginal fluid and preterm delivery. Human Reproduction, 28, 942–952.CrossRefGoogle ScholarPubMed
van Kammen, D. P., McAllister-Sistilli, C. G., Kelley, M. E., Gurklis, J. A., & Yao, J. K. (1999). Elevated interleukin-6 in schizophrenia. Psychiatry Research, 87, 129–136.Google Scholar
Waldinger, R. J., & Schulz, M. S. (2016). The long reach of nurturing family environments: Links with midlife emotion-regulatory styles and late-life security in intimate relationships. Psychological Science, 27, 1443–1450. doi:10.1177/0956797616661556 CrossRefGoogle Scholar
Whisman, M. A., & Bruce, M. L. (1999). Marital distress and incidence of major depressive episode in a community sample. Journal of Abnormal Psychology, 108, 674–678. doi:10.1037/021-843X.108.4.674 Google Scholar
Young, J. R. (2012). Underemployment in urban and rural America, 2005–2012. Durham, NH: University of New Hampshire, Carsey Institute.Google Scholar
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