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Genetic and neurocognitive contributions to the development of psychopathy

Published online by Cambridge University Press:  11 July 2012

Essi Viding  and
Eamon J. McCrory
Essi Viding*
Affiliation:
University College London
Eamon J. McCrory
Affiliation:
University College London
*
Address correspondence and reprint requests to: Essi Viding, Division of Psychology and Language Sciences, University College London, Gower Street, London WC1 6BT, United Kingdom; E-mail: [email protected].
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Abstract

An overview is provided of recent twin, molecular genetic, and magnetic resonance imaging studies that are helping to inform a model of developmental vulnerability to adult psychopathy. Although the current evidence base suggests that children with high levels of callous–unemotional traits are genetically and neurocognitively vulnerable to developing psychopathic and antisocial behaviors, existing research also clearly indicates that environmental influences play an important role. One potential implication is that interventions for children with antisocial behavior and callous–unemotional traits may need to be tailored to take into account their distinct pattern of neurocognitive vulnerability, as revealed by developmental neuroimaging studies. Specifically, interventions that pursue punishment-oriented or explicit empathy induction strategies may be less effective with this group of antisocial children. By contrast, preliminary evidence suggests that enhancing positive parenting and parental involvement, as well as applying consistent rewards may represent more promising intervention approaches.

Type
Articles
Information
Development and Psychopathology , Volume 24 , Issue 3: Multilevel Approaches Toward Understanding Antisocial Behavior: Current Research and Future Directions , August 2012 , pp. 969 - 983
Copyright
Copyright © Cambridge University Press 2012

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References

Barker, E. D., Oliver, B. R., Viding, E., Salekin, R. T., & Maughan, B. (2011). The impact of prenatal maternal risk, fearless temperament and early parenting on adolescent callous–unemotional traits: A 14-year longitudinal investigation. Journal of Child Psychology and Psychiatry, 52, 878–888.CrossRefGoogle ScholarPubMed
Bezdjian, S., Raine, A., Baker, L. A., & Lynam, D. R. (2011). Psychopathic personality in children: Genetic and environmental contributions. Psychological Medicine, 41, 589–600.CrossRefGoogle ScholarPubMed
Birbaumer, N., Veit, R., Lotze, M., Erb, M., Hermann, C., Grodd, W., et al. (2005). Deficient fear conditioning in psychopathy: A functional magnetic resonance imaging study. Archives of General Psychiatry, 62, 799–805.CrossRefGoogle ScholarPubMed
Blair, R. J. R., & Viding, E. (2008). Psychopathy. In Rutter, A., Bishop, M., Pine, D., Scott, D., Stevenson, S., Taylor, J., et al. (Eds.), Rutter's child and adolescent psychiatry (5th ed., pp. 852–863). Hoboken, NJ: Wiley.CrossRefGoogle Scholar
Blair, R. J. R. (2010). Neuroimaging of psychopathy and antisocial behavior: A targeted review. Current Psychiatry Reports, 12, 76–82.CrossRefGoogle ScholarPubMed
Blonigen, D. M., Carlson, S. R., Krueger, R. F., & Patrick, C. J. (2003). A twin study of self-reported personality traits. Personality and Individual Differences, 35, 179–197.CrossRefGoogle Scholar
Blonigen, D. M., Hicks, B. M., Krueger, R. F., Patrick, C. J., & Iacono, W. G. (2005). Psychopathic personality traits: Heritability and genetic overlap with internalizing and externalizing psychopathology. Psychological Medicine, 35, 637–648.CrossRefGoogle ScholarPubMed
Blonigen, D. M., Hicks, B. M., Krueger, R. F., Patrick, C. J., & Iacono, W. G. (2006). Continuity and change in psychopathic traits as measured via normal-range personality: A longitudinal-biometric study. Journal of Abnormal Psychology, 115, 85–95.CrossRefGoogle ScholarPubMed
Bouchard, T. J., & Loehlin, J. C. (2001). Genes, personality and evolution. Behavioural Genetics, 31, 243–273.CrossRefGoogle Scholar
Buckholtz, J. W., & Meyer-Lindenberg, A. (2008). MAOA and the neurogenetic architecture of human aggression. Trends in Neurosciences, 31, 120–129.CrossRefGoogle ScholarPubMed
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Benning, S. D., Li, R., et al. (2010). Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature Neuroscience, 13, 419–421.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597–600.CrossRefGoogle Scholar
Crapanzano, A. M., Frick, P. J., Childs, K., & Terranova, A. M. (2011). Gender differences in the assessment, stability, and correlates to bullying roles in middle school children. Differences, 694, 677–694.Google Scholar
Dadds, M. R., Jambrak, J., Pasalich, D., Hawes, D. J., & Brennan, J. (2011). Impaired attention to the eyes of attachment figures and the developmental origins of psychopathy. Journal of Child Psychology and Psychiatry, 52, 238–245.CrossRefGoogle Scholar
Dadds, M. R., Perry, Y., Hawes, D. J., Merz, S., Riddell, A. C., Haines, D. J., et al. (2006). Attention to the eyes reverses fear-recognition deficits in child psychopathy. British Journal of Psychiatry, 189, 280–281.CrossRefGoogle Scholar
Dadds, M. R., & Rhodes, T. (2008). Aggression in young children with concurrent callous–unemotional traits: Can the neurosciences inform progress and innovation in treatment approaches? Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 2567–2576.CrossRefGoogle ScholarPubMed
Dandreaux, D., & Frick, P. (2009). Developmental pathways to conduct problems: A further test of the childhood and adolescent-onset distinction. Journal of Abnormal Child Psychology, 37, 375–385.CrossRefGoogle ScholarPubMed
De Brito, S. A, Mechelli, A., Wilke, M., Laurens, K. R., Jones, A. P., Barker, G. J., et al. (2009). Size matters: Increased grey matter in boys with conduct problems and callous–unemotional traits. Brain, 132, 843–852.CrossRefGoogle ScholarPubMed
De Brito, S. A., McCrory, E. J., Mechelli, A., Wilke, M., Jones, A. P., Hodgins, S., et al. (2011). Small, but not perfectly formed: Decreased white matter concentration in boys with psychopathic tendencies. Molecular Psychiatry, 16, 476–477.CrossRefGoogle Scholar
De Wied, M., van Boxtel, A., Matthys, W., & Meeus, W. (2011). Verbal, facial and autonomic responses to empathy-eliciting film clips by disruptive male adolescents with high versus low callous–unemotional traits. Journal of Abnormal Child Psychology, 40, 211–223.CrossRefGoogle Scholar
Fairchild, G., Passamonti, L., Hurford, G., Hagan, C. C., von dem Hagen, E. A. H., van Goozen, S. H. M., et al. (2011). Brain structure abnormalities in early-onset and adolescent-onset conduct disorder. American Journal of Psychiatry, 6, 1–10.Google Scholar
Finger, E., Marsh, A., & Mitchell, D. (2008). Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning. Archives of General Psychiatry, 65, 586–594.CrossRefGoogle ScholarPubMed
Finger, E. C., Marsh, A. A., Blair, K. S., Reid, M. E., Sims, C., Ng, P., et al. (2011). Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. American Journal of Psychiatry, 168, 152–162.CrossRefGoogle ScholarPubMed
Fontaine, N. M. G., McCrory, E. J. P., Boivin, M., Moffitt, T. E., & Viding, E. (2011). Predictors and outcomes of joint trajectories of callous–unemotional traits and conduct problems in childhood. Journal of Abnormal Psychology, 120, 730–742.CrossRefGoogle ScholarPubMed
Fontaine, N. M. G., Rijsdijk, F. V., McCrory, E. J. P., & Viding, E. (2010). Etiology of different developmental trajectories of callous–unemotional traits. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 656–664.Google ScholarPubMed
Forsman, M., Larsson, H., Andershed, H., & Lichtenstein, P. (2007). Persistent disruptive childhood behavior and psychopathic personality in adolescence: A twin study. British Journal of Developmental Psychology, 25, 383–398.CrossRefGoogle Scholar
Forsman, M., Lichtenstein, P., Andershed, H., & Larsson, H. (2008). Genetic effects explain the stability of psychopathic personality from mid- to late adolescence. Journal of Abnormal Psychology, 117, 606–617.CrossRefGoogle ScholarPubMed
Forsman, M., Lichtenstein, P., Andershed, H., & Larsson, H. (2010). A longitudinal twin study of the direction of effects between psychopathic personality and antisocial behaviour. Journal of Child Psychology and Psychiatry, 51, 39–47.CrossRefGoogle ScholarPubMed
Fowler, T., Langley, K., Rice, F., van den Bree, M. B. M., Ross, K., Wilkinson, L. S., et al. (2009). Psychopathy trait scores in adolescents with childhood ADHD: The contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics, 19, 312–319.CrossRefGoogle ScholarPubMed
Frick, P. J., Cornell, A. H., Barry, C. T., Bodin, S. D., & Dane, H. E. (2003). Callous–unemotional traits and conduct problems in the prediction of conduct problem severity, aggression, and self-report of delinquency. Journal of Abnormal Child Psychology, 31, 457–470.CrossRefGoogle ScholarPubMed
Frick, P. J., Lilienfeld, S. O., Ellis, M., Loney, B., & Silverthorn, P. (1999). The association between anxiety and psychopathy dimensions in children. Journal of Abnormal Child Psychology, 27, 383–392.CrossRefGoogle ScholarPubMed
Frick, P. J., & Moffitt, T. E. (2010). A proposal to the DSM-V Childhood Disorders and the ADHD and Disruptive Behavior Disorders Work Groups to include a specifier to the diagnosis of conduct disorder based on the presence of callous–unemotional traits. Unpublished manuscript.Google Scholar
Frick, P. J., & Viding, E. (2009). Antisocial behavior from a developmental psychopathology perspective. Development and Psychopathology, 21, 1111–1131.CrossRefGoogle ScholarPubMed
Gao, Y., Glenn, A. L., Schug, R. A., Yang, Y., & Raine, A. (2009). The neurobiology of psychopathy: A neurodevelopmental perspective. Canadian Journal of Psychiatry, 54, 813–823.CrossRefGoogle ScholarPubMed
Glenn, A. L. (2011). The other allele: Exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: A review of the parallels in findings. Neuroscience and Biobehavioral Reviews, 35, 612–620.CrossRefGoogle Scholar
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituziz, A. C., et al. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Science, 101, 8174–8179.CrossRefGoogle ScholarPubMed
Hare, R. D., & Neumann, C. N. (2006). The PCL-R assessment of psychopathy: Development, structural properties, and new directions. In Patrick, C. J. (Ed.), Handbook of psychopathy (pp. 58–88). New York: Guilford Press.Google Scholar
Hawes, D. J., & Dadds, M. R. (2005). The treatment of conduct problems in children with callous–unemotional traits. Journal of Consulting and Clinical Psychology, 73, 737–741.CrossRefGoogle ScholarPubMed
Hawes, D. J., & Dadds, M. R. (2007). Stability and malleability of callous–unemotional traits during treatment for childhood conduct problems. Journal of Clinical Child and Adolescent Psychology, 35, 347–355.CrossRefGoogle Scholar
Hawes, D. J., Dadds, M. R., Frost, A. D. J., & Hasking, P. A. (2011). Do childhood callous–unemotional traits drive change in parenting practices? Journal of Clinical Child and Adolescent Psychology, 40, 507–518.CrossRefGoogle ScholarPubMed
Hicks, B., & Patrick, C. (2006). Psychopathy and negative emotionality: Analyses of suppressor effects reveal distinct relations with emotional distress, fearfulness, and anger-hostility. Journal of Abnormal Psychology, 11, 276–287.CrossRefGoogle Scholar
Jones, A. P., Laurens, K. R., Herba, C. M., Barker, G. J., & Viding, E. (2009). Amygdala hypoactivity to fearful faces in boys with conduct problems and callous–unemotional traits. American Journal of Psychiatry, 166, 95–102.CrossRefGoogle ScholarPubMed
Jones, A. P., Happé, F. G., Gilbert, F., Burnett, S., & Viding, E. (2010). Feeling, caring, knowing: Different types of empathy deficit in boys with psychopathic tendencies and autism spectrum disorder. Journal of Child Psychology and Psychiatry, 51, 1188–1197.CrossRefGoogle ScholarPubMed
Kiehl, K. A., Smith, A. M., Hare, R. D., Mendrek, A., Forster, B. B., Brink, J., et al. (2001). Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biological Psychiatry, 50, 677–684.CrossRefGoogle ScholarPubMed
Kumsta, R., Sonuga-Barke, E., & Rutter, M. (in press). Adolescent callous–unemotional traits and conduct disorder in adoptees exposed to severe early deprivation. British Journal of Psychiatry.Google Scholar
Larsson, H., Tuvblad, C., Rijsdijk, F., Andershed, H., Grann, M., & Lichtenstein, P. (2007). A common genetic factor explains the association between psychopathic personality and antisocial behaviour. Psychological Medicine, 37, 15–26.CrossRefGoogle Scholar
Larsson, H., Andershed, H., & Lichtenstein, P. (2006). A genetic factor explains most of the variation in the psychopathic personality. Journal of Abnormal Psychology, 115, 221–230.CrossRefGoogle ScholarPubMed
Larsson, H., Viding, E., & Plomin, R. (2008). Callous–unemotional traits and antisocial behavior. Criminal Justice and Behavior, 35, 197–211.CrossRefGoogle Scholar
Lynam, D. R., Derefinko, K. J., Caspi, A., Loeber, R., & Stouthamer-Loeber, M. (2007). The content validity of juvenile psychopathy: An empirical examination. Psychological Assessment, 19, 363–367.CrossRefGoogle ScholarPubMed
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000). A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Research, 95, 9–23.CrossRefGoogle ScholarPubMed
Marsh, A. A., & Blair, R. J. (2008). Deficits in facial affect recognition among antisocial populations: A meta-analysis. Neuroscience and Biobehavioral Reviews, 32, 454–465.CrossRefGoogle ScholarPubMed
Marsh, A. A., Finger, E. C., Mitchell, D. G., Reid, M. E., Sims, C., Kosson, D. S., et al. (2008). Reduced amygdala response to fearful expressions in children and adolescents with callous–unemotional traits and disruptive behavior disorders. American Journal of Psychiatry, 165, 712–720.CrossRefGoogle ScholarPubMed
Marsh, A. A., Kozak, M. N., Wegner, D. M., Reid, M. E., Yu, H. H., & Blair, R. J. R. (2010). The neural substrates of action identification. Social Cognitive and Affective Neuroscience, 5, 392–403.CrossRefGoogle ScholarPubMed
Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B. R, Hariri, A., Pezawas, L., Blasi, G., et al. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences of the United States of America, 103, 6269–6274.CrossRefGoogle ScholarPubMed
Mitchell, D. G. (2011). The nexus between decision making and emotion regulation: A review of convergent neurocognitive substrates. Behavioural Brain Research, 217, 215–231.CrossRefGoogle ScholarPubMed
Munafo, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype andamygdala activation: A meta-analysis. Biological Psychiatry, 63, 852–857.CrossRefGoogle ScholarPubMed
Muñoz, L. C. (2009). Callous–unemotional traits are related to combined deficits in recognizing afraid faces and body poses. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 554–562.CrossRefGoogle ScholarPubMed
Muñoz, L. C., Qualter, P., & Padgett, G. (2011). Empathy and bullying: Exploring the influence of callous–unemotional traits. Child Psychiatry and Human Development, 42, 183–196.CrossRefGoogle ScholarPubMed
Pardini, D. A., & Fite, P. J. (2010). Symptoms of conduct disorder, oppositional defiant disorder, attention-deficit/hyperactivity disorder, and callous–unemotional traits as unique predictors of psychosocial maladjustment in boys: Advancing an evidence base for DSM-V. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 1134–1144.Google ScholarPubMed
Pardini, D. A., Lochman, J. E., & Powell, N. (2007). The development of callous–unemotional traits and antisocial behavior in children: Are there shared and/or unique predictors? Journal of Clinical Child and Adolescent Psychology, 36, 319–333.CrossRefGoogle ScholarPubMed
Passamonti, L., Fairchild, G., Goodyer, I. M., Hurford, G., Hagan, C. C., Rowe, J. B., et al. (2010). Neural abnormalities in early-onset and adolescence-onset conduct disorder. Archives of General Psychiatry, 67, 729–738.CrossRefGoogle ScholarPubMed
Rijsdijk, F. V., Viding, E., DeBrito, S., Forgiarini, M., Mechelli, A., Jones, A. P., et al. (2010). Heritable variations in gray matter concentration as a potential endophenotype for psychopathic traits. Archives of General Psychiatry, 67, 406–413.CrossRefGoogle ScholarPubMed
Rowe, R., Costello, E. J., Angold, A., Copeland, W. E., & Maughan, B. (2010). Developmental pathways in oppositional defiant disorder and conduct disorder. Journal of Abnormal Psychology, 119, 726–738.CrossRefGoogle ScholarPubMed
Rubia, K., Smith, A. B., Halari, R., Matsukura, F., Mohammad, M., Taylor, E., et al. (2009). Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. American Journal of Psychiatry, 166, 83–94.CrossRefGoogle ScholarPubMed
Sadeh, N., Javdani, S., Jackson, J. J., Reynolds, E. K., Potenza, M. N., Gelernter, J., et al. (2010). Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources. Journal of Abnormal Psychology, 119, 604–609.CrossRefGoogle ScholarPubMed
Scheepers, F. E., Buitelaar, J. K., & Matthys, W. (2011). Conduct disorder and the specifier callous and unemotional traits in the DSM-V. European Child and Adolescent Psychiatry, 20, 89–93.CrossRefGoogle Scholar
Sebastian, C. L., McCrory, E. J. P., Cecil, A. M., Lockwood, P. L., De Brito, S. A., Fontaine, N. M. G., et al. (in press). Neural responses to affective and cognitive theory of mind in children with conduct problems and varying levels of callous–unemotional traits. Archives of General Psychiatry.Google Scholar
Sherer, C., & Nickerson, A. (2010) Anti-bullying practices in American schools: Perspectives of school psychologists. Psychological Schools, 47, 217–229.CrossRefGoogle Scholar
Shaw, P., Gogtay, N., & Rapoport, J. (2010). Childhood psychiatric disorders as anomalies in neurodevelopmental trajectories. Human Brain Mapping, 31, 917–925.CrossRefGoogle ScholarPubMed
Silverthorn, P., Frick, P. J., & Reynolds, R. (2001). Timing of onset and correlates of severe conduct problems in adjudicated girls and boys. Journal of Psychopathology and Behavioral Assessment, 23, 171–181.CrossRefGoogle Scholar
Smith, P. K., Pepler, D. J., & Rigby, K. (2004). Bullying in schools: How successful can interventions be? New York: Cambridge University Press.CrossRefGoogle Scholar
Sterzer, P., & Stadler, C. (2009). Neuroimaging of aggressive and violent behaviour in children and adolescents. Frontiers in Behavioral Neuroscience, 3, 35.CrossRefGoogle ScholarPubMed
Sylvers, P. D., Brennan, P. A., & Lilienfeld, S. O. (2011). Psychopathic traits and preattentive threat processing in children. Psychological Science. Advance online publication. doi:10.1177/0956797611420730.CrossRefGoogle ScholarPubMed
Taylor, J., Loney, B. R., Bobadilla, L., lacono, W. G., & McGue, M. (2003). Genetic and environmental influences on psychopathy trait dimensions in a community sample of male twins. Journal of Abnormal Child Psychology, 31, 633–645.CrossRefGoogle Scholar
Viding, E., Blair, R. J. R., Moffitt, T. E., & Plomin, R. (2005). Evidence for substantial genetic risk for psychopathy in 7-years-olds. Journal of Child Psychology and Psychiatry, 46, 592–597.CrossRefGoogle Scholar
Viding, E., Fontaine, N. M. G., Oliver, B. R., & Plomin, R. (2009). Negative parental discipline, conduct problems and callous–unemotional traits: Monozygotic twin differences study. British Journal of Psychiatry, 195, 414–419.CrossRefGoogle ScholarPubMed
Viding, E., Frick, P. J., & Plomin, R. (2007). Aetiology of the relationship between callous–unemotional traits and conduct problems in childhood. British Journal of Psychiatry, 49, 33–38.CrossRefGoogle ScholarPubMed
Viding, E., Hanscombe, K. B., Curtis, C. J. C., Davis, O. S. P., Meaburn, E. L., & Plomin, R. (2010). In search of genes associated with risk for psychopathic tendencies in children: A two-stage genome-wide association study of pooled DNA. Journal of Child Psychology and Psychiatry, 7, 780–788.CrossRefGoogle Scholar
Viding, E., & Jones, A. P. (2008). Cognition to genes via the brain in the study of conduct disorder. Quarterly Journal of Experimental Psychology, 61, 171–181.CrossRefGoogle Scholar
Viding, E., Jones, A. P., Frick, P. J., Moffitt, T. E., & Plomin, R. (2008). Heritability of antisocial behaviour at 9: Do callous–unemotional traits matter? Developmental Science, 11, 17–22.CrossRefGoogle ScholarPubMed
Viding, E., McCrory, E. J., Blakemore, S.-J., & Frederickson, N. (2011). Behavioural problems and bullying at school: Can cognitive neuroscience shed new light on an old problem? Trends in Cognitive Sciences, 15, 289–291.Google Scholar
Vizard, E., Hickey, N., & McCrory, E. (2007). Developmental trajectories associated with juvenile sexually abusive behaviour and emerging severe personality disorder in childhood: 3-Year study. British Journal of Psychiatry, 190, S27–S32.CrossRefGoogle Scholar
Yang, Y., & Raine, A. (2009). Prefrontal structural and functional brain imaging findings in antisocial, violent and psychopathic individuals: A meta-analysis. Psychiatry Research, 174, 81–88.CrossRefGoogle ScholarPubMed