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From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth

Published online by Cambridge University Press:  22 November 2017

Elizabeth D. Handley ,
Fred A. Rogosch  and
Dante Cicchetti
Elizabeth D. Handley*
Affiliation:
University of Rochester Mt. Hope Family Center
Fred A. Rogosch
Affiliation:
University of Rochester Mt. Hope Family Center
Dante Cicchetti
Affiliation:
University of Rochester Mt. Hope Family Center University of Minnesota Institute of Child Development
*
Address correspondence and reprint requests to: Elizabeth Handley, Mt. Hope Family Center, University of Rochester, 187 Edinburgh Street, Rochester, NY 14608; E-mail: [email protected].
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Abstract

The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of two prospective sequential mediators of an internalizing pathway to problematic drinking, namely, childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies; and identify a subgroup of maltreated children most susceptible to progressing along this less common pathway of risk.

Type
Special Issue Articles
Information
Development and Psychopathology , Volume 29 , Special Issue 5: Biological and Behavioral Effects of Early Adversity on Multiple Levels of Development , December 2017 , pp. 1807 - 1821
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

We are grateful to the Jacobs Foundation (to D.C.) and the National Institute on Drug Abuse (R01-DA01774 to F.A.R. and D.C.) for their support of this work.

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