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Executive functioning, cortisol reactivity, and symptoms of psychopathology in girls with premature adrenarche

Published online by Cambridge University Press:  31 January 2012

Lisa M. Sontag-Padilla ,
Lorah D. Dorn ,
Abbigail Tissot ,
Elizabeth J. Susman ,
Sue R. Beers  and
Susan R. Rose
Lisa M. Sontag-Padilla*
Affiliation:
RAND Corporation
Lorah D. Dorn
Affiliation:
Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine
Abbigail Tissot
Affiliation:
Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine
Elizabeth J. Susman
Affiliation:
Pennsylvania State University
Sue R. Beers
Affiliation:
University of Pittsburgh School of Medicine
Susan R. Rose
Affiliation:
Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine
*
Address correspondence and reprint requests to: Lisa M. Sontag-Padilla, Rand Corporation, 4570 Fifth Avenue, Suite 600, Pittsburgh, PA 15213-2665; E-mail: [email protected].
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Abstract

The study examined the interaction between early maturational timing (measured by premature adrenarche [PA]) and executive functioning and cortisol reactivity on symptoms of psychopathology. The study included 76 girls aged 6 through 8 years (mean = 7.50, SD = 0.85) with PA (n = 40) and on-time adrenarche (n = 36). Girls completed a battery of psychological and neuropsychological tests and blood sampling for cortisol. Parents completed the Child Behavior Checklist. The results demonstrated that girls with PA with lower levels of executive functioning had higher externalizing and anxious symptoms compared to other girls. In addition, girls with PA who demonstrated increases in serum cortisol had higher externalizing symptoms than those with stable patterns. Finally, girls with PA who demonstrated decreases in cortisol reported higher depressive symptoms. The findings from this study provide important information concerning the impact of cognitive functioning and stress reactivity on adjustment to early maturation in girls with PA. The results of this research may inform screening and intervention efforts for girls who may be at greatest risk for emotional and behavioral problems as a result of early maturation.

Type
Regular Articles
Information
Development and Psychopathology , Volume 24 , Issue 1 , February 2012 , pp. 211 - 223
Copyright
Copyright © Cambridge University Press 2012

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References

Achenbach, T. M. (1991). Manual for the Youth Self-Report and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry.Google Scholar
Barkley, R. A. (2002). ADHD: Long-term course, adult outcome, and comorbid disorders. In Jensen, P. S. & Cooper, J. R. (Eds.), Attention-deficit/hyperactivity disorder: State of the science and best practices (pp. 4-1–4-12). Kingston, NJ: Civic Research Institute.Google Scholar
Bender, R., & Lange, S. (1999). Multiple test procedures other than Bonferroni's deserve wider use. British Medical Journal, 318, 600.CrossRefGoogle ScholarPubMed
Blair, C., & Diamond, A. (2008). Biological processes in prevention and intervention: The promotion of self-regulation as a means of preventing school failure. Development and Psychopathology, 20, 899–911.CrossRefGoogle ScholarPubMed
Blakemore, S. J., & Choudhury, S. (2006). Development of the adolescent brain: Implications for executive function and social cognition. Journal of Child Psychology and Psychiatry, 47, 296–312.Google Scholar
Brooks-Gunn, J., Petersen, A. C., & Eichorn, D. (1985). The study of maturational timing effects in adolescence. Journal of Youth and Adolescence, 14, 149–161.Google Scholar
Campbell, L. K., Scaduto, M., Van Slyke, D., Niarhos, F., Whitlock, J. A., & Compas, B. E. (2009). Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. Journal of Pediatric Psychology, 34, 317–327.CrossRefGoogle ScholarPubMed
Caspi, A., Lynam, D., Moffitt, T. E., & Silva, P. A. (1993). Unraveling girls' delinquency: Biological, dispositional, and contextual contributions to adolescent misbehavior. Developmental Psychology, 29, 19–30.Google Scholar
Cicchetti, D., & Walker, E. F. (2001). Stress and development: Biological and psychological consequences. Development and Psychopathology, 13, 413–418.CrossRefGoogle Scholar
Cole, D. A., Hoffman, K., Tram, J. M., & Maxwell, S. E. (2000). Structural differences in parent and child reports of children's symptoms of depression and anxiety. Psychological Assessment, 12, 174–185.CrossRefGoogle ScholarPubMed
Dahl, R. E. (2004). Adolescent brain development: A period of vulnerabilities and opportunities. Annals of the New York Academy of Sciences, 1021, 1–22.CrossRefGoogle ScholarPubMed
de Zegher, F., & Ibáñez, L. (2009). Early origins of polycystic ovary syndrome: Hypotheses may change without notice. Journal of Clinical Endocrinology and Metabolism, 94, 3682–3685.CrossRefGoogle ScholarPubMed
Derogatis, L. R. (1993). BSI Brief Symptom Inventory. Administration, scoring, and procedures manual (4th ed.). Minneapolis, MN: National Computer Systems.Google Scholar
Diamantopoulou, S., Rydell, A. M., Thorell, L. B., & Bohlin, G. (2007). Impact of executive functioning and symptoms of attention deficit hyperactivity disorder on children's peer relations and school performance. Developmental Neuropsychology, 32, 521–542.Google Scholar
Dickerson, S. S., & Kemeny, M. E. (2004). Acute stressors and cortisol responses: A theoretical integration and synthesis of laboratory research. Psychological Bulletin, 130, 355–391.CrossRefGoogle ScholarPubMed
Dorn, L. D. (2007). Psychological and social problems in children with premature adrenarche and precocious puberty. In Pescovitz, O. H. & Walvoord, E. C. (Eds.), When puberty is precocious: Scientific and clinical aspects (pp. 309–327). Totowa, NJ: Humana Press.CrossRefGoogle Scholar
Dorn, L. D., Hitt, S. F., & Rotenstein, D. (1999). Biopsychological and cognitive differences in children with premature vs. on-time adrenarche. Archives of Pediatric & Adolescent Medicine, 153, 137–146.CrossRefGoogle ScholarPubMed
Dorn, L. D., Rose, S. R., Rotenstein, D., Susman, E. J., Huang, B., Loucks, T. L., et al. (2008). Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. Journal of Pediatric Endocrinology and Metabolism, 21, 439–448.CrossRefGoogle ScholarPubMed
Dorn, L. D., & Rotenstein, D. (2004). Early puberty in girls: The case of premature adrenarche. Women's Health Issues, 14, 177–183.CrossRefGoogle ScholarPubMed
Ehrhardt, A. A., & Meyer-Bahlburg, H. F. L. (1986). Idiopathic precocious puberty in girls: Long-term effects on adolescent behavior. Acta Endocrinologica, 112, 247–253.Google Scholar
Ge, X., Brody, G. H., Conger, R. D., Simons, R. L., & Murry, V. M. (2002). Contextual amplification of pubertal transition effects on deviant peer affiliation and externalizing behavior among African American children. Developmental Psychology, 38, 42–54.Google Scholar
Ge, X., & Natsuaki, M. N. (2009). In search of explanations for early pubertal timing effects on developmental psychopathology. Current Directions in Psychological Science, 18, 327–331.CrossRefGoogle Scholar
Giedd, J. N., Clasen, L. S., Lenroot, R., Greenstein, D., Wallace, G. L., Ordaz, S., et al. (2006). Puberty-related influences on brain development. Molecular and Cellular Endocrinology, 254–255, 154–162.Google Scholar
Graber, J. A., Seeley, J. R., Brooks-Gunn, J., & Lewinsohn, P. M. (2004). Is pubertal timing associated with psychopathology in young adulthood? Journal of the American Academy of Child & Adolescent Psychiatry, 43, 718–726.CrossRefGoogle ScholarPubMed
Granger, D. A., Weisz, J. R., & Kauneckis, D. (1994). Neuroendocrine reactivity, internalizing behavior problems, and control-related cognitions in clinic-referred children and adolescents. Journal of Abnormal Psychology, 103, 267–276.CrossRefGoogle ScholarPubMed
Greve, K. W., Ingram, F., & Bianchini, K. J. (1998). Latent structure of the Wisconsin Card Sorting Test in a clinical sample. Archives of Clinical Neuropsychology, 13, 597–609.Google Scholar
Gunnar, M. R., Wewerka, S., Frenn, K., Long, J. D., & Griggs, C. (2009). Developmental changes in HPA activity over the transition to adolescence: Normative changes and associations with puberty. Development and Psychopathology, 21, 69–85.Google Scholar
Hankin, B. L., Badanes, L. S., Abuela, J., & Watamura, S. E. (2010). Hypothalamic pituitary adrenal axis dysregulation in dysphoric children and adolescents: Cortisol reactivity to psychosocial stress from preschool through middle adolescence. Biological Psychiatry, 68, 484–490.CrossRefGoogle ScholarPubMed
Heaton, R. K., Chelune, G. J., Talley, J. L., Kay, G. G., & Curtiss, G. (1993). Wisconsin Card Sorting Test manual: Revised and expanded. Odessa, FL: Psychological Assessment Resources.Google Scholar
Hollingshead, A. B. (1975). Four Factor Index of Social Status. New Haven, CT: Yale University Press.Google Scholar
Ibáñez, L., Díaz, R., López-Bermejo, A., & Marcos, M. V. (2009). Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism. Reviews in Endocrine & Metabolic Disorders, 10, 63–76.CrossRefGoogle ScholarPubMed
Ibáñez, L., Dimartino-Nardi, J., Potau, N., & Saenger, P. (2000). Premature adrenarche—Normal variant or forerunner of adult disease? Endocrine Reviews, 21, 671–696.Google ScholarPubMed
Kao, M., Voina, S., Nichols, A., & Horton, R. (1975). Parallel radioimmunoassay for plasma cortisol and 11-deoxycortisol. Clinical Chemistry, 21, 1644–1647.CrossRefGoogle ScholarPubMed
Klimes-Dougan, B., Hastings, P. D., Granger, D. A., Usher, B. A., & Zahn-Waxler, C. (2001). Adrenocortical activity in at-risk and normally developing adolescents: Individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Development and Psychopathology, 13, 695–719.Google Scholar
Kolb, B., & Fantie, B. D. (2009). Development of the child's brain and behavior. In Reynolds, C. R. & Fletcher-Janzen, E. (Eds.), Handbook of clinical child neuropsychology (3rd ed., pp. 19–46). New York: Springer.Google Scholar
Kovacs, M. (1992). Children's depression inventory manual. North Tonawanda, NY: Multi-Health Systems, Inc.Google Scholar
Kudielka, B. M., Hellhammer, D. H., & Kirschbaum, C. (2007). Ten years of research with the Trier Social Stress Test—revisited. In Harmon-Jones, E. & Winkleman, P. (Eds.), Social neuroscience: Integrating biological and psychological explanations (pp. 56–83). New York: Guilford Press.Google Scholar
Lopez-Duran, N. L., Olson, S. L., Hajal, N. J., Felt, B. T., & Vazquez, D. M. (2009). Hypothalamic pituitary adrenal axis functioning in reactive and proactive aggression in children. Journal of Abnormal Child Psychology, 37, 169–182.CrossRefGoogle ScholarPubMed
Luby, J. L., Belden, A., Sullivan, J., & Spitznagel, E. (2007). Preschoolers' contribution to their diagnosis of depression and anxiety: Uses and limitations of young child self-report of symptoms. Child Psychiatry & Human Development, 38, 321–338.Google Scholar
Luby, J. L., Heffelfinger, A. K., Mrakotsky, C., Brown, K. M., Hessler, M. J., & Spitznagel, E. (2003). Alterations in stress cortisol reactivity in depressed preschoolers relative to psychiatric and no-disorder comparison groups Archives of General Psychiatry, 60, 1248–1255.Google Scholar
Marshall, W. A., & Tanner, J. M. (1969). Variations in pattern of pubertal changes in girls. Archives of Disease in Childhood, 44, 291–303.CrossRefGoogle ScholarPubMed
McCarthy, A. M., Hanrahan, K., Kleiber, C., Zimmerman, M. B., Lutgendorf, S., & Tsalikian, E. (2009). Normative salivary cortisol values and responsivity in children. Applied Nursing Research, 22, 54–62.CrossRefGoogle ScholarPubMed
Mendle, J., Turkheimer, E., & Emery, R. E. (2007). Detrimental psychological outcomes associated with early pubertal timing in adolescent girls. Developmental Review, 27, 151–171.Google Scholar
Mericq, V. (2006). Low birth weight and endocrine dysfunction in postnatal life. Pediatric Endocrinology Reviews, 4, 3–14.Google Scholar
Miller, M., & Hinshaw, S. P. (2010). Does childhood executive function predict adolescent functional outcomes in girls with ADHD? Journal of Abnormal Child Psychology, 38, 315–326.Google Scholar
Moreno, J., Silverman, W. K., Saavedra, L. M., & Phares, V. (2008). Fathers' ratings in the assessment of their child's anxiety symptoms: A comparison to mothers' ratings and their associations with paternal symptomatology. Journal of Family Psychology, 22, 915–919.CrossRefGoogle ScholarPubMed
Nelson, E. E., Leibenluft, E., McClure, E. B., & Pine, D. S. (2005). The social re-orientation of adolescence: A neuroscience perspective on the process and its relation to psychopathology. Psychological Medicine, 35, I163–I174.Google Scholar
Ouimet, L. A., Stewart, A., Collins, B., Schindler, D., & Bielajew, C. (2009). Measuring neuropsychological change following breast cancer treatment: An analysis of statistical models. Journal of Clinical and Experimental Neuropsychology, 31, 73–89.CrossRefGoogle ScholarPubMed
Paus, T. (2005). Mapping brain maturation and cognitive development during adolescence. Trends in Cognitive Science, 9, 60–68.CrossRefGoogle ScholarPubMed
Pepera, J.S., Brouwer, R. M., Schnack, H. G., van Baal, G.C., van Leeuwen, M., van den Berg, S. M., et al. (2009). Sex steroids and brain structure in pubertal boys and girls. Psychoneuroendocrinology, 34, 332–342.CrossRefGoogle Scholar
Perneger, T.V. (1998). What's wrong with Bonferroni adjustments. British Medical Journal, 316, 1236–1238.CrossRefGoogle ScholarPubMed
Perrin, J. S., Hervé, P., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., et al. (2008). Growth of white matter in the adolescent brain: Role of testosterone and androgen receptor. Journal of Neuroscience, 28, 9519–9524.Google Scholar
Petersen, A. C., & Taylor, B. (1980). The biological approach to adolescence: Biological and psychosocial adaptation. In Adelson, J. (Ed.), Handbook of the psychology of adolescence (pp. 115–155). New York: Wiley.Google Scholar
Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916–931.CrossRefGoogle ScholarPubMed
Reiter, E. O., & Kulin, H. (1972). Sexual maturation in the female: Normal development and precocious puberty. Pediatric Clinics of North America, 19, 581–603.Google Scholar
Reiter, E. O., & Saenger, P. (1997). Premature adrenarche. The Endocrinologist, 7, 85–88.Google Scholar
Rothen, S., Vandeleur, C. L., Lustenberger, Y., Jeanpretre, N., Ayer, E., Gamma, F., et al. (2009). Parent–child agreement and prevalence estimates of diagnoses in childhood: Direct interview versus family history method. International Journal of Methods in Psychiatric Research, 18, 96–109.CrossRefGoogle ScholarPubMed
Sisk, C. L., & Zehr, J. L. (2005). Pubertal hormones organize the adolescent brain and behavior. Frontiers in Neuroendocrinology, 26, 163–174.CrossRefGoogle ScholarPubMed
Shirtcliff, E. A., & Essex, M. J. (2008). Concurrent and longitudinal associations of basal and diurnal cortisol with mental health symptoms in early adolescence. Developmental Psychobiology, 50, 690–703.Google Scholar
Shirtcliff, E. A., Vitacco, M.J., Graf, A., Gostisha, A., Merz, J.L., & Zahn-Waxler, C. (2009). Neurobiology of empathy and callousness: Implications for the development of antisocial behavior. Behavioral Sciences and the Law, 27, 1–35.CrossRefGoogle ScholarPubMed
Sklar, C. A., Kaplan, S. L., & Grumbach, M. M. (1980). Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and development. Journal of Clinical Endocrinology and Metabolism, 51, 548–556.Google Scholar
Spielberger, C. D. (1973). State-Trait Anxiety Inventory for Children manual. Palo Alto, CA: Consulting Psychologists Press.Google Scholar
Sontag, L. M., Graber, J. A., Brooks-Gunn, J., & Warren, M. P. (2008). Coping with social stress: Implications for psychopathology in young adolescent girls. Journal of Abnormal Child Psychology, 36, 1159–1174.CrossRefGoogle ScholarPubMed
Steinberg, L. (2008). A social neuroscience perspective on adolescent risk-taking. Developmental Review, 28, 78–106.Google Scholar
Stroud, L., Foster, E., Handwerger, K., Papandonatos, G. D., Granger, D., Kivlinghan, K. T., et al. (2009). Stress response and the adolescent transition: Performance versus peer rejection stress. Development and Psychopathology, 21, 47–68.CrossRefGoogle ScholarPubMed
Su, C. Y., Chen, H. M., Kwan, A. L., Lin, Y. H., & Guod, N. W. (2007). Neuropsychological impairment after hemorrhagic stroke in basal ganglia. Archives of Clinical Neuropsychology, 22, 465–474.Google Scholar
Susman, E. J. (2006). Psychobiology of persistent antisocial behavior: Stress, early vulnerabilities and the attenuation hypothesis. Neuroscience and Biobehavioral Reviews, 30, 376–389.Google Scholar
Susman, E. J., Dockray, S., Granger, D. A., Blades, K. T., Randazzo, W., Heaton, J. A., et al. (2010). Cortisol and alpha amylase reactivity and timing of puberty: Vulnerabilities for antisocial behaviour in young adolescents. Psychoneuroendocrinology, 35, 557–569Google Scholar
Susman, E. J., & Dorn, L. D. (2009). Puberty: Its role in development. In Lerner, R. M. & Steinberg, L. (Eds.), Handbook of adolescent psychology (3rd ed., Vol. 1, pp. 116–151). Hoboken, NJ: Wiley.Google Scholar
Susman, E. J., Dorn, L. D., Inoff-Germain, G., Nottelmann, E. D., & Chrousos, G. P. (1997). Cortisol reactivity, distress behavior, behavior problems, and emotionality in young adolescents: A longitudinal perspective. Journal of Research on Adolescence, 7, 81–105.Google Scholar
Tabachnick, B. G., & Fidell, L. S. (2007). Using multivariate statistics (5th ed.).Boston:Allyn & Bacon.Google Scholar
Tissot, A., Dorn, L. D., Rotenstein, D., Rose, S. R., Sontag, L. M., Jillard, C. L., et al. (2010). Neuropsychological functioning in girls with premature adrenarche: An investigation of hormonal influences. Unpublished manuscript.Google Scholar
van Goozen, S., Fairchild, G., Snoek, H., & Harold, G. T. (2007). The evidence for a neurobiological model of childhood antisocial behavior. Psychological Bulletin, 133, 149–182.CrossRefGoogle ScholarPubMed
van West, D., Claes, S., Sulon, J., & Deboutte, D. (2008). Hypothalamic–pituitary–adrenal reactivity in prepubertal children with social phobia. Journal of Affective Disorders, 111, 281–290.Google Scholar
Vostanis, P., Graves, A., Meltzer, H., Goodman, R., Jenkins, R., & Brugha, T. (2006). Relationship between parental psychopathology, parenting strategies and child mental health. Social Psychiatry and Psychiatric Epidemiology, 41, 509–514.Google Scholar
Walker, E. F., Sabuwalla, Z., & Huout, R. (2004). Pubertal neuromaturation, stress sensitivity, and psychopathology. Development and Psychopathology, 16, 807–824.Google Scholar
Weschler, D. (1991). Weschler Intelligence Scale for Children (3rd ed.). San Antonio, TX: Psychological Corp.Google Scholar
Wahlstedt, C., Thorell, L. B, & Bohlin, G. (2008). ADHD symptoms and executive function impairment: Early predictors of later behavioral problems. Developmental Neuropsychology, 33, 160–178.CrossRefGoogle ScholarPubMed
Whittaker, D. (2003). The use of z scores in assessing neuropsychological change after cardiac operations. Annals of Thoracic Surgery, 75, 1066.Google Scholar