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Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study

Published online by Cambridge University Press:  22 November 2017

Robert Keers  and
Michael Pluess
Robert Keers
Affiliation:
Queen Mary University of London
Michael Pluess*
Affiliation:
Queen Mary University of London
*
Address correspondence and reprint requests to: Michael Pluess, Department of Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK; E-mail: [email protected].
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Abstract

While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses.

Type
Special Issue Articles
Information
Development and Psychopathology , Volume 29 , Special Issue 5: Biological and Behavioral Effects of Early Adversity on Multiple Levels of Development , December 2017 , pp. 1921 - 1933
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

This work made use of data and samples generated by the 1958 Birth Cohort (National Child Development Study), which is managed by the Centre for Longitudinal Studies at the University College London Institute of Education, funded by Economic and Social Research Council Grant ES/M001660/1. Access to these resources was enabled via the 58READIE Project funded by Wellcome Trust and Medical Research Council Grant WT095219MA and G1001799. A full list of the financial, institutional, and personal contributions to the development of the 1958 Birth Cohort Biomedical resource is available at http://www2.le.ac.uk/projects/birthcohort/1958bc/about/contributors-funders. Genotyping was undertaken as part of the Wellcome Trust Case-Control Consortium under Wellcome Trust Award 076113, and a full list of the investigators who contributed to the generation of the data is available at http://www.wtccc.org.uk. Dr. Keers was supported by MRC Population Health Scientist Award MR/K021281/1. We are grateful to the Centre for Longitudinal Studies, Institute of Education, for the use of these data and to the UK Data Service for making them available. However, neither Centre for Longitudinal Studies nor the UK Data Service bears any responsibility for the analysis or interpretation of these data.

References

Amato, P. R. (2010). Research on divorce: Continuing trends and new developments. Journal of Marriage and Family, 72, 650–666. doi:10.1111/j.1741-3737.2010.00723.x CrossRefGoogle Scholar
Amone-P'Olak, K., Burger, H., Ormel, J., Huisman, M., Verhulst, F. C., & Oldehinkel, A. J. (2009). Socioeconomic position and mental health problems in pre- and early-adolescents: The TRAILS study. Social Psychiatry and Psychiatric Epidemiology, 44, 231–238. doi:10.1007/s00127-008-0424-z CrossRefGoogle ScholarPubMed
Amstadter, A. B., Myers, J. M., & Kendler, K. S. (2014). Psychiatric resilience: Longitudinal twin study. British Journal of Psychiatry, 205, 275–280. doi:10.1192/bjp.bp.113.130906 Google Scholar
Aron, E. N., & Aron, A. (1997). Sensory-processing sensitivity and its relation to introversion and emotionality. Journal of Personality and Social Psychology, 73, 345–368.Google Scholar
Aron, E. N., Aron, A., & Jagiellowicz, J. (2012). Sensory processing sensitivity: A review in the light of the evolution of biological responsivity. Personality and Social Psychology Review, 16, 262–282. doi:10.1177/1088868311434213 Google Scholar
Assary, E., Zavos, H. M., Krapohl, E., Keers, R., & Pluess, M. (2017). Sensitivity to the environment is a heritable personality trait. Manuscript submitted for publication.Google Scholar
Belsky, J. (1997). Variation in susceptibility to rearing influences: An evolutionary argument. Psychological Inquiry, 8, 182–186.CrossRefGoogle Scholar
Belsky, J. (2005). Differential susceptibility to rearing influences: An evolutionary hypothesis and some evidence. In Ellis, B. & Bjorklund, D. (Eds.), Origins of the social mind: Evolutionary psychology and child development (pp. 139–163). New York: Guilford Press.Google Scholar
Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300–304. doi.10.1111/j.1467-8721.2007.00525.x Google Scholar
Belsky, J., & Beaver, K. M. (2011). Cumulative-genetic plasticity, parenting and adolescent self-regulation. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 52, 619–626. doi:10.1111/j.1469-7610.2010.02327.x Google Scholar
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885–908. doi:10.1037/a0017376 CrossRefGoogle ScholarPubMed
Belsky, J., & Pluess, M. (2013). Beyond risk, resilience, and dysregulation: Phenotypic plasticity and human development. Development and Psychopathology, 25, 1243–1261. doi:10.1017/S095457941300059X CrossRefGoogle ScholarPubMed
Binder, E. B., Bradley, R. G., Liu, W., Epstein, M. P., Deveau, T. C., Mercer, K. B., … Ressler, K. J. (2008). Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. Journal of the American Medical Association, 299, 1291–1305. doi:10.1001/jama.299.11.1291 Google Scholar
Bogdan, R., Williamson, D. E., & Hariri, A. R. (2012). Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity. American Journal of Psychiatry, 169, 515–522. doi:10.1176/appi.ajp.2011.11060855 CrossRefGoogle ScholarPubMed
Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271–301.CrossRefGoogle ScholarPubMed
Brett, Z. H., Humphreys, K. L., Smyke, A. T., Gleason, M. M., Nelson, C. A., Zeanah, C. H., … Drury, S. S. (2015). Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior. Development and Psychopathology, 27, 7–18. doi:10.1017/S0954579414001266 CrossRefGoogle ScholarPubMed
Brown, G. W., Craig, T. K., & Harris, T. O. (2008). Parental maltreatment and proximal risk factors using the Childhood Experience of Care & Abuse (CECA) instrument: A life-course study of adult chronic depression—5. Journal of Affective Disorders, 110, 222–233. doi:10.1016/j.jad.2008.01.016 Google Scholar
Brown, G. W., & Harris, T. O. (1978). Social origins of depression: A study of psychiatric disorder in women. New York: Free Press.Google Scholar
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389. doi:10.1126/science.1083968 CrossRefGoogle ScholarPubMed
Cicchetti, D. (2013). Annual research review: Resilient functioning in maltreated children—Past, present, and future perspectives. Journal of Child Psychology and Psychiatry, 54, 402–422. doi:10.1111/j.1469-7610.2012.02608.x Google Scholar
Cicchetti, D., & Rogosch, F. A. (2012). Gene × Environment interaction and resilience: Effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genes. Development and Psychopathology, 24, 411–427. doi:10.1017/S0954579412000077 Google Scholar
Cicchetti, D., Rogosch, F. A., & Oshri, A. (2011). Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Development and Psychopathology, 23, 1125–1138. doi:10.1017/s0954579411000599 Google Scholar
Covault, J., Tennen, H., Armeli, S., Conner, T. S., Herman, A. I., Cillesson, A. H., & Kranzler, H. R. (2007). Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biological Psychiatry, 61, 609–616. doi:10.1016/j.biopsych.2006.05.018 Google Scholar
Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R. (2013). The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology, 38, 1858–1873. doi:10.1016/j.psyneuen.2013.06.008 CrossRefGoogle ScholarPubMed
DeYoung, C. G., Cicchetti, D., & Rogosch, F. A. (2011). Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 52, 898–906. doi:10.1111/j.1469-7610.2011.02404.x CrossRefGoogle ScholarPubMed
Dougherty, L. R., Klein, D. N., & Davila, J. (2004). A growth curve analysis of the course of dysthymic disorder: The effects of chronic stress and moderation by adverse parent-child relationships and family history. Journal of Consulting and Clinical Psychology, 72, 1012–1021. doi:10.1037/0022-006X.72.6.1012 CrossRefGoogle ScholarPubMed
Drury, S. S., Gleason, M. M., Theall, K. P., Smyke, A. T., Nelson, C. A., Fox, N. A., & Zeanah, C. H. (2012). Genetic sensitivity to the caregiving context: The influence of 5HTTLPR and BDNF val66met on indiscriminate social behavior. Physiology & Behavior, 106, 728–735. doi:10.1016/j.physbeh.2011.11.014 Google Scholar
Drury, S. S., Theall, K. P., Smyke, A. T., Keats, B. J., Egger, H. L., Nelson, C. A., … Zeanah, C. H. (2010). Modification of depression by COMT val 158 met polymorphism in children exposed to early severe psychosocial deprivation. Child Abuse and Neglect, 34, 387–395. doi:10.1016/j.chiabu.2009.09.021 CrossRefGoogle ScholarPubMed
Eley, T. C., Hudson, J. L., Creswell, C., Tropeano, M., Lester, K. J., Cooper, P., … Collier, D. A. (2012). Therapygenetics: The 5HTTLPR and response to psychological therapy. Molecular Psychiatry, 17, 236–241. doi:10.1038/mp.2011.132 Google Scholar
Ellis, B. J., & Boyce, W. T. (2008). Biological sensitivity to context. Current Directions in Psychological Science, 17, 183–187.Google Scholar
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory. Development and Psychopathology, 23, 7–28. doi:10.1017/S0954579410000611 Google Scholar
Elovainio, M., Jokela, M., Kivimaki, M., Pulkki-Raback, L., Lehtimaki, T., Airla, N., & Keltikangas-Jarvinen, L. (2007). Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: Cardiovascular risk in young Finns study. Psychosomatic Medicine, 69, 391–395. doi:10.1097/psy.0b013e31806bf365 CrossRefGoogle ScholarPubMed
Fergusson, D. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. British Journal of Psychiatry, 198, 129–135. doi:10.1192/bjp.bp.110.085993 CrossRefGoogle ScholarPubMed
Forssman, L., Peltola, M. J., Yrttiaho, S., Puura, K., Mononen, N., Lehtimaki, T., & Leppanen, J. M. (2014). Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 55, 793–801. doi:10.1111/jcpp.12181 Google Scholar
Frodl, T., Reinhold, E., Koutsouleris, N., Donohoe, G., Bondy, B., Reiser, M., … Meisenzahl, E. M. (2010). Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology, 35, 1383–1390. doi:10.1038/npp.2010.8 CrossRefGoogle ScholarPubMed
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., … Williams, L. M. (2009). Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry, 14, 681–695. doi:10.1038/mp.2008.143 Google Scholar
Grabe, H. J., Schwahn, C., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., … Freyberger, H. J. (2012). Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sample. American Journal of Medical Genetics, 159 B, 298–309. doi:10.1002/ajmg.b.32027 Google Scholar
Hammen, C. (2005). Stress and depression. Annual Review of Clinical Psychology, 1, 293–319. doi:10.1146/annurev.clinpsy.1.102803.143938 Google Scholar
Hammen, C., Henry, R., & Daley, S. E. (2000). Depression and sensitization to stressors among young women as a function of childhood adversity. Journal of Consulting and Clinical Psychology, 68, 782–787.Google Scholar
Hankin, B. L., Nederhof, E., Oppenheimer, C. W., Jenness, J., Young, J. F., Abela, J. R. Z., … Oldehinkel, A. J. (2011). Differential susceptibility in youth: Evidence that 5-HTTLPR × Positive Parenting is associated with positive affect “for better and worse.” Translational Psychiatry, 1, e44. doi:10.1038/tp.2011.44 Google Scholar
Harkness, K. L., Bruce, A. E., & Lumley, M. N. (2006). The role of childhood abuse and neglect in the sensitization to stressful life events in adolescent depression. Journal of Abnormal Psychology, 115, 730–741. doi:10.1037/0021-843X.115.4.730 Google Scholar
Heim, C., Bradley, B., Mletzko, T. C., Deveau, T. C., Musselman, D. L., Nemeroff, C. B., … Binder, E. B. (2009). Effect of childhood trauma on adult depression and neuroendocrine function: Sex-specific moderation by CRH receptor 1 gene. Frontiers in Behavioral Neuroscience, 3, 41. doi:10.3389/neuro.08.041.2009 Google Scholar
Hosang, G. M., Uher, R., Keers, R., Cohen-Woods, S., Craig, I., Korszun, A., … Farmer, A. E. (2010). Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder. Journal of Affective Disorders, 125, 345–349. doi:10.1016/j.jad.2010.01.071 CrossRefGoogle ScholarPubMed
Johansson, A., Bergman, H., Corander, J., Waldman, I. D., Karrani, N., Salo, B., … Westberg, L. (2012). Alcohol and aggressive behavior in men—Moderating effects of oxytocin receptor gene (OXTR) polymorphisms. Genes, Brain and Behavior, 11, 214–221. doi:10.1111/j.1601-183X.2011.00744.x Google Scholar
Jokela, M., Keltikangas-Jarvinen, L., Kivimaki, M., Puttonen, S., Elovainio, M., Rontu, R., & Lehtimaki, T. (2007). Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms. Archives of General Psychiatry, 64, 356–360. doi:10.1001/archpsyc.64.3.356 Google Scholar
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444–454. doi:10.1001/archgenpsychiatry.2010.189 Google Scholar
Keers, R., Coleman, J. R. I., Lester, K. J., Roberts, S., Breen, G., Thastum, M., … Eley, T. C. (2016). A genome-wide test of the differential susceptibility hypothesis reveals a genetic predictor of differential response to psychological treatments for child anxiety disorders. Psychotherapy and Psychosomatics. Advance online publication. doi:10.1159/000444023 CrossRefGoogle Scholar
Keltikangas-Jarvinen, L., Puttonen, S., Kivimaki, M., Elovainio, M., Rontu, R., & Lehtimaki, T. (2007). Tryptophan hydroxylase 1 gene haplotypes modify the effect of a hostile childhood environment on adulthood harm avoidance. Genes, Brain and Behavior, 6, 305–313. doi:10.1111/j.1601-183X.2006.00255.x Google Scholar
Kendler, K. S., Hettema, J. M., Butera, F., Gardner, C. O., & Prescott, C. A. (2003). Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Archives of General Psychiatry, 60, 789–796. doi:10.1001/archpsyc.60.8.789 Google Scholar
Kendler, K. S., Kuhn, J. W., & Prescott, C. A. (2004). Childhood sexual abuse, stressful life events and risk for major depression in women. Psychological Medicine, 34, 1475–1482.CrossRefGoogle ScholarPubMed
Kohen, R., Cain, K. C., Buzaitis, A., Johnson, V., Becker, K. J., Teri, L., … Mitchell, P. H. (2011). Response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms. Stroke, 42, 2068–2070.Google Scholar
Kumsta, R., Stevens, S., Brookes, K., Schlotz, W., Castle, J., Beckett, C., … Sonuga-Barke, E. (2010). 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: Evidence from the English and Romanian Adoptee (ERA) study. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 51, 755–762. doi:10.1111/j.1469-7610.2010.02249.x Google Scholar
Lester, K., Hudson, J. L., Tropeano, M., Creswell, C., Collier, D., Farmer, A., … Eley, T. (2012). Neurotrophic gene polymorphisms and response to psychological therapy. Translational Psychiatry, 2, e108. doi:10.1038/tp.2012.33 Google Scholar
McCrory, E., De Brito, S. A., & Viding, E. (2010). Research review: The neurobiology and genetics of maltreatment and adversity. Journal of Child Psychology and Psychiatry, 51, 1079–1095. doi:10.1111/j.1469-7610.2010.02271.x Google Scholar
McLaughlin, K. A., Conron, K. J., Koenen, K. C., & Gilman, S. E. (2010). Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: A test of the stress sensitization hypothesis in a population-based sample of adults. Psychological Medicine, 40, 1647–1658. doi:10.1017/S0033291709992121 Google Scholar
Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406.CrossRefGoogle ScholarPubMed
Munafo, M. R., Durrant, C., Lewis, G., & Flint, J. (2009). Gene × Environment interactions at the serotonin transporter locus. Biological Psychiatry, 65, 211–219. doi:10.1016/j.biopsych.2008.06.009 CrossRefGoogle ScholarPubMed
Pluess, M. (2015). Individual differences in environmental sensitivity. Child Development Perspectives, 9, 138–143. doi:10.1111/cdep.12120 Google Scholar
Pluess, M., & Belsky, J. (2011). Prenatal programming of postnatal plasticity? Development and Psychopathology, 23, 29–38. doi:10.1017/S0954579410000623 Google Scholar
Pluess, M., & Belsky, J. (2013). Vantage sensitivity: Individual differences in response to positive experiences. Psychological Bulletin, 139, 901–916. doi:10.1037/a0030196 Google Scholar
Pluess, M., Belsky, J., Way, B. M., & Taylor, S. E. (2010). 5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 1070–1704. doi:10.1016/j.pnpbp.2010.05.028 CrossRefGoogle ScholarPubMed
Pluess, M., Stevens, S., & Belsky, J. (2013). Differential susceptibility: Developmental and evolutionary mechanisms of gene-environment interactions. In Legerstee, M., Haley, D. W., & Bornstein, M. H. (Eds.), The infant mind: Origins of the social brain (pp. 77–96). New York: Guilford Press.Google Scholar
Power, C., & Elliott, J. (2006). Cohort profile: 1958 British birth cohort (National Child Development Study). International Journal of Epidemiology, 35, 34–41. doi:10.1093/ije/dyi183 CrossRefGoogle ScholarPubMed
Power, R. A., Lecky-Thompson, L., Fisher, H. L., Cohen-Woods, S., Hosang, G. M., Uher, R., … McGuffin, P. (2013). The interaction between child maltreatment, adult stressful life events and the 5-HTTLPR in major depression. Journal of Psychiatric Research, 47, 1032–1035. doi:10.1016/j.jpsychires.2013.03.017 Google Scholar
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., … Merikangas, K. R. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462–2471.Google Scholar
Rutter, M., Tizard, J., & Whitmore, K. (1970). Malaise Inventory. In Rutter, M., Tizard, J., & Whitmore, K. (Eds.), Education, health and behaviour (pp. 339–340). London: Longman.Google Scholar
Shapero, B. G., Black, S. K., Liu, R. T., Klugman, J., Bender, R. E., Abramson, L. Y., & Alloy, L. B. (2014). Stressful life events and depression symptoms: The effect of childhood emotional abuse on stress reactivity. Journal of Clinical Psychology, 70, 209–223. doi:10.1002/jclp.22011 CrossRefGoogle ScholarPubMed
Shepherd, P. (2012). 1958 National Child Development Study ethical review and consent. London: Institute of Education.Google Scholar
Slavich, G. M., Thornton, T., Torres, L. D., Monroe, S. M., & Gotlib, I. H. (2009). Targeted rejection predicts hastened onset of major depression. Journal of Social and Clinical Psychology, 28, 223–243. doi:10.1521/jscp.2009.28.2.223 Google Scholar
Starr, L. R., Hammen, C., Conway, C. C., Raposa, E., & Brennan, P. A. (2014). Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. Development and Psychopathology, 26, 1241–1254. doi:10.1017/S0954579414000996 Google Scholar
StataCorp. (2011). Stata statistical software: Release 12. College Station, TX: Author.Google Scholar
Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry, 60, 671–676. doi:10.1016/j.biopsych.2006.04.019 Google Scholar
Troisi, A., Frazzetto, G., Carola, V., Di Lorenzo, G., Coviello, M., Siracusano, A., & Gross, C. (2012). Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment. Social Cognitive and Affective Neuroscience, 7, 542–547. doi:10.1093/scan/nsr037 CrossRefGoogle ScholarPubMed
Tyrka, A. R., Price, L. H., Gelernter, J., Schepker, C., Anderson, G. M., & Carpenter, L. L. (2009). Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: Effects on hypothalamic-pituitary-adrenal axis reactivity. Biological Psychiatry, 66, 681–685. doi:10.1016/j.biopsych.2009.05.012 Google Scholar
Uher, R. (2008). The implications of gene-environment interactions in depression: Will cause inform cure? Molecular Psychiatry, 13, 1070–1078. doi:10.1038/mp.2008.92 Google Scholar
Uher, R. (2014). Gene–environment interactions in common mental disorders: An update and strategy for a genome-wide search. Social Psychiatry and Psychiatric Epidemiology, 49, 3–14. doi:10.1007/s00127-013-0801-0 Google Scholar
Uher, R., & McGuffin, P. (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry, 15, 18–22. doi:10.1038/mp.2009.123 Google Scholar
van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2015). Genetic differential susceptibility on trial: Meta-analytic support from randomized controlled experiments. Development and Psychopathology, 27, 151–162. doi:10.1017/S0954579414001369 Google Scholar
Zannas, A. S., & Binder, E. B. (2014). Gene-environment interactions at the FKBP5 locus: Sensitive periods, mechanisms and pleiotropism. Genes, Brain and Behavior, 13, 25–37. doi:10.1111/gbb.12104 Google Scholar
Zuckerman, M. (1999). Diathesis-stress models. In Zuckerman, M. (Ed.), Vulnerability to psychopathology: A biosocial model. Washington, DC: American Psychological Association.Google Scholar