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Adolescent females exposed to child maltreatment exhibit atypical EEG coherence and psychiatric impairment: Linking early adversity, the brain, and psychopathology

Published online by Cambridge University Press:  28 April 2010

Vladimir Miskovic ,
Louis A. Schmidt ,
Katholiki Georgiades ,
Michael Boyle  and
Harriet L. Macmillan
Vladimir Miskovic
Affiliation:
McMaster University
Louis A. Schmidt*
Affiliation:
McMaster University McMaster Children's Hospital
Katholiki Georgiades
Affiliation:
McMaster University McMaster Children's Hospital
Michael Boyle
Affiliation:
McMaster University McMaster Children's Hospital
Harriet L. Macmillan
Affiliation:
McMaster University McMaster Children's Hospital
*
Address correspondence and reprint requests to: Louis A. Schmidt, Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ONT L8S 4K1, Canada; E-mail: [email protected].
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Abstract

Although the relation between child maltreatment and psychiatric impairment is well documented and preliminary evidence has linked child maltreatment with aberrant cortical connectivity of the left hemisphere, no investigations have attempted to examine these relations in the same study. Here, we examined the links among early adversity, brain connectivity, and functional outcomes. We collected resting regional EEG intra- and interhemispheric α-band (7.5–12.5 Hz) coherence and measures of general psychiatric impairment from a cohort of 38 adolescent females exposed to child maltreatment (M age = 14.47) and 24 adolescent females not exposed to child maltreatment (M age = 14.00). Maltreated youths exhibited more left hemisphere EEG coherence than the control youths, suggesting a suboptimal organization of cortical networks. Maltreated participants also showed reduced frontal (anterior) interhemispheric coherence. These differences in brain circuitry remained statistically significant even after controlling for group differences in pubertal status and socioeconomic status. Measures of functional brain connectivity were associated with several subtypes of abuse and neglect. It was important that atypical left hemisphere EEG coherence mediated the effects of child maltreatment on levels of psychiatric impairment. The findings are discussed in the context of models linking early adversity to brain function and psychopathology.

Type
Regular Articles
Information
Development and Psychopathology , Volume 22 , Issue 2 , May 2010 , pp. 419 - 432
Copyright
Copyright © Cambridge University Press 2010

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