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A Mathematical Model for the Instigation and Transmission of Biological and Neural Signals in Response to Acupuncture

Part of: Physiological, cellular and medical topics Mathematical biology in general

Published online by Cambridge University Press:  15 October 2015

Wei Yao ,
Na Yin ,
Hongwei Yang  and
Guanghong Ding
Wei Yao
Affiliation:
Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Mechanics and Engineering Science, Fudan University, 220 Handan Road, Shanghai, 200433, P.R.China
Na Yin
Affiliation:
Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Mechanics and Engineering Science, Fudan University, 220 Handan Road, Shanghai, 200433, P.R.China
Hongwei Yang
Affiliation:
Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Mechanics and Engineering Science, Fudan University, 220 Handan Road, Shanghai, 200433, P.R.China
Guanghong Ding*
Affiliation:
Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Department of Mechanics and Engineering Science, Fudan University, 220 Handan Road, Shanghai, 200433, P.R.China Shanghai Research Center for Acupuncture and Meridian, 199 Guoshoujing Road, Pudong, Shanghai, 201203, P.R.China
*
*Corresponding author. Email addresses: [email protected] (W. Yao), [email protected] (N. Yin), [email protected] (H. W. Yang), [email protected] (G. H. Ding)
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Abstract

Acupuncture has been in clinical practice in China for thousands of years and its analgesia effect is worldwide accepted. However, the mechanism of acupuncture effect is not well understood. The study focus on signaling pathways induced by acupuncture, analyzes the cooperative action of the acupoints’ structure and the associated chemical mediators during acupuncture, establishes a mathematical model clarifying the roadmap of electroneurographic signal startup and transmission mechanism induced by acupuncture, quantitatively analyzing the response in acupoints to acupuncture. These work contribute to reveal the activation and transmission mechanism of neural signals induced by acupuncture from systems biology perspective, lay the foundation for the integration of acupuncture theory and modern science and further guide the clinical treatment and experimental research of acupuncture.

Keywords

Mast cellnerve cellCa2+ signalingbiological mediators releaseacupuncture

MSC classification

Secondary: 92C10: Biomechanics 92C05: Biophysics 92C42: Systems biology, networks 92B05: General biology and biomathematics
Type
Research Article
Information
Communications in Computational Physics , Volume 18 , Issue 4 , October 2015 , pp. 868 - 880
Copyright
Copyright © Global-Science Press 2015 

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