This special issue is devoted to papers from the meeting on Combinatorics and Probability, held at the Mathematisches Forschungsinstitut in Oberwolfach from 26 April to 2 May. This meeting focused on the common themes of Combinatorics, Discrete Probability and Theoretical Computer Science, and the lectures, many of which were given by young participants, stimulated fruitful discussions. The open problems session held during the meeting, and the fact that the participants work in different and related topics, encouraged interesting discussions and collaborations.