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The Therapeutic Potential of 5-HT1B Autoreceptors and Heteroreceptors and 5-HT-Moduline in CNS Disorders

Published online by Cambridge University Press:  07 November 2014

Hala Sarhan  and
Gilles Fillion
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Abstract

The endogenous peptide 5-HT–moduline has been characterized as a novel neuropeptide that binds to 5-HT1B receptors in the brain areas in which it is released. By inducing structural changes in these receptors, this peptide prevents 5-HT binding, thereby desensitizing the receptors and inhibiting serotonergic function. This novel mechanism may help to explain differential effects of the serotonergic system in varying areas of the brain that are innervated by the same or few neurons. In addition, dysfunction or disruption of the 5-HT–moduline system may contribute to psychiatric disorders such as depression and anxiety, and may have important implications for the development of new therapeutic agents for these disorders.

Type
Feature Article
Information
CNS Spectrums , Volume 3 , Issue 8: Serotonin Subsystems , September 1998 , pp. 50 - 58
Copyright
Copyright © Cambridge University Press 1998

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