Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-25T07:03:19.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Stimulants for impulsive violence in schizophrenia spectrum disordered women: a case series and brief review

Published online by Cambridge University Press:  16 May 2016

Philip Skoretz  and
Chin Tang
Philip Skoretz*
Affiliation:
Department of Psychiatry, Department of State Hospitals–Patton, Patton, California, USA
Chin Tang
Affiliation:
Department of Psychiatry and Human Behavior, University of California–Irvine, Orange, California, USA
*
*Address for correspondence: Philip Skoretz, MD, Department of Psychiatry, Department of State Hospitals–Patton, 3102 East Highland Avenue, Patton, CA 92369, USA. (Email: [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

High violence prevalence is a common concern for forensic psychiatric settings. Categorizing underlying drivers of violence has helped to direct treatment and management efforts toward psychotic, predatory, and impulsively violent psychopathology. This article describes a series of cases in which clozapine provided adequate control of psychosis in women suffering schizophrenia-spectrum disorders. Nevertheless, impulsive violence remained problematic. Add-on methylphenidate was found to be safe and effective in curbing impulsive violent behavior in this select group of patients.

Keywords

Impulsivityschizophreniastimulantsviolencewomen
Type
Case-Based Review Article
Information
CNS Spectrums , Volume 21 , Issue 6 , December 2016 , pp. 445 - 449
Copyright
© Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

†

The authors wish to thank Michael Cummings, MD, Jonathan Meyer, MD, and George Proctor, MD for their assistance.

References

1. Quanbeck, CD, McDermott, BE, Lam, J, Eisenstark, H, Sokolov, G, Scott, CL. Categorization of aggressive acts committed by chronically assaultive state hospital patients. Psychiatr Serv. 2007; 58(4): 521–528.CrossRefGoogle ScholarPubMed
2. Warburton, K. The new mission of forensic mental health systems: managing violence as a medical syndrome in an environment that balances treatment and safety. CNS Spectr. 2014; 19(5): 368–373.CrossRefGoogle Scholar
3. McDonagh, M, Peterson, K, Carson, S, Fu, R, Thakurta, S. Drug class reviews. In Drug Class Review: Atypical Antipsychotic Drugs: Final Update 3 Report. Portland, OR: Oregon Health & Science University; 2010.Google Scholar
4. Sheard, MH, Marini, JL, Bridges, CI, Wagner, E. The effect of lithium on impulsive aggressive behavior in man. Am J Psychiatry. 1976; 133(12): 1409–1413.Google ScholarPubMed
5. Kane, JM, Leucht, S, Carpenter, D, Docherty, JP, Expert Consensus Panel for Optimizing Pharmacologic Treatment of Psychotic D. The expert consensus guideline series: optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary. J Clin Psychiatry. 2003; 64(Suppl 12): 5–19.Google ScholarPubMed
6. Citrome, L. The psychopharmacology of violence with emphasis on schizophrenia, Part 1: acute treatment. J Clin Psychiatry. 2007; 68(1): 163–164.CrossRefGoogle ScholarPubMed
7. Humble, F, Berk, M. Pharmacological management of aggression and violence. Hum Psychopharmacol. 2003; 18(6): 423–436.CrossRefGoogle ScholarPubMed
8. Volavka, J. Violence in schizophrenia and bipolar disorder. Psychiatr Danub. 2013; 25(1): 24–33.Google ScholarPubMed
9. Frogley, C, Taylor, D, Dickens, G, Picchioni, M. A systematic review of the evidence of clozapine’s anti-aggressive effects. Int J Neuropsychopharmacol. 2012; 15(9): 1351–1371.CrossRefGoogle ScholarPubMed
10. Spivak, B, Mester, R, Wittenberg, N, Maman, Z, Weizman, A. Reduction of aggressiveness and impulsiveness during clozapine treatment in chronic neuroleptic-resistant schizophrenic patients. Clin Neuropharmacol. 1997; 20(5): 442–446.CrossRefGoogle ScholarPubMed
11. Englisch, S, Zink, M. Treatment-resistant schizophrenia: evidence-based strategies. Mens Sana Monogr. 2012; 10(1): 20–32.Google ScholarPubMed
12. Dalsgaard, S, Thomsen, PH. Evidence-based treatment of ADHD/DAMP in children and adolescents with central stimulants. Ugeskr Laeger. 2001; 163(8): 1116–1121.Google ScholarPubMed
13. Thomaes, K, Dorrepaal, E, Drajijer, N, et al. Reduced anterior cingulate and orbitofrontal volumes in child-abuse-related complex PTSD. J Clin Psychiatry. 2010; 71(12): 1636–1644.CrossRefGoogle ScholarPubMed
14. Stahl, SM. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Application, 4th ed. Cambridge, UK: Cambridge University Press; 2013.Google Scholar
15. Biederman, J, Mick, E, Surman, C, et al. A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2006; 59(9): 829–835.CrossRefGoogle ScholarPubMed
16. Lieberman, JA, Alvir, J, Geisler, S, et al. Methylphenidate response, psychopathology and tardive dyskinesia as predictors of relapse in schizophrenia. Neuropsychopharmacology. 1994; 11(2): 107–118.CrossRefGoogle ScholarPubMed
17. Koreen, AR, Lieberman, JA, Alvir, J, Chakos, M. The behavioral effect of m-chlorophenylpiperazine (mCPP) and methylphenidate in first-episode schizophrenia and normal controls. Neuropsychopharmacology. 1997; 16(1): 61–68.CrossRefGoogle ScholarPubMed
18. Jody, D, Lieberman, JA, Geisler, S, Szymanski, S, Alvir, JM. Behavioral response to methylphenidate and treatment outcome in first episode schizophrenia. Psychopharmacol Bull. 1990; 26(2): 224–230.Google ScholarPubMed
19. Lieberman, JA, Kane, JM, Gadaleta, D, Brenner, R, Lesser, MS, Kinon, B. Methylphenidate challenge as a predictor of relapse in schizophrenia. Am J Psychiatry. 1984; 141(5): 633–638.Google ScholarPubMed
20. Hammerness, PG, Karampahtsis, C, Babalola, R, Alexander, ME. Attention-deficit/hyperactivity disorder treatment: what are the long-term cardiovascular risks? Expert Opin Drug Saf. 2015; 4(4): 543–551.CrossRefGoogle Scholar
21. Giotakos, O. Aggressive behavior: theoretical and biological aspects. Psychiatriki. 2013; 24(2): 117–131.Google ScholarPubMed
22. Curran, C, Byrappa, N, Mcbride, N. Stimulant psychosis: systematic review. Br J Psychiatry. 2004; 185(3): 196–204.CrossRefGoogle ScholarPubMed
23. Weisler, RH, Childress, AC. Treating attention-deficit/hyperactivity disorder in adults: focus on once-daily medications. Prim Care Companion CNS Disord. 2011; 13(6): PCC 11r01168.Google ScholarPubMed