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Psychosis Associated with Anti-N-methyl-d-aspartate Receptor Antibodies

Published online by Cambridge University Press:  07 November 2014

Kevin M. Nasky ,
Douglas R. Knittel  and
Gail H. Manos
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Abstract

We describe the eighth case study of a female diagnosed with anti-N-methyl-d-aspartate receptor encephalitis without an identified tumor who presented with floridly psychotic symptoms following a 2-week prodromal phase with new-onset headaches and presyncopal episodes. While hospitalized, the patient had seizures, autonomic dysfunction, involuntary movements, and a decline in mental status. A subsequent assay was positive for anti-N-methyl-d-aspartate receptor antibodies. In contrast to most reported cases, an initial trial with corticosteroids was therapeutically unsuccessful. Subsequent treatment with intravenous immunoglobulins, however, resulted in a prompt, robust clinical response and enabled the patient to be rapidly discharged from the hospital, with minimal neuropsychiatrie sequelae.

Type
Case Report
Information
CNS Spectrums , Volume 13 , Issue 8 , August 2008 , pp. 699 - 703
Copyright
Copyright © Cambridge University Press 2008

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