Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-17T13:16:05.770Z Has data issue: false hasContentIssue false

Personalized Medicine, Pharmacogenomics, and the Practice of Psychiatry: On the Threshold of Predictive Therapeutics in Psychopharmacology?

Published online by Cambridge University Press:  07 November 2014

Extract

Personalizing medicine by understanding the unique properties of each patient's genome has the potential of predicting what drug to prescribe for that individual. This approach has already proven useful for several drugs in medicine and promises to become a strategy for selection of therapeutics in psychiatry soon. Understanding some of the key concepts, strategies, and advances in the field of pharmacogenomics can set the stage for adapting emerging findings to the practice of psychopharmacology.

Type
Trends in Psychopharmacology
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Grossman, I. Routine pharmacogenetic testing in clinical practice: dream or reality? Pharmacogenomics. 2007;8:14491459.Google Scholar
2. Gordon, E. Integrating genomics and neuromarkers for the era of brain-related personalized medicine. Personalized Medicine. 2007;4:201215.Google Scholar
3. Stahl, SM. Stahl's Essential Psychopharmacology. 3rd ed. New York, NY: Cambridge University Press; 2008.Google Scholar
4. Pander, J, Gelderblom, H, Guchelaar, HJ. Insights into the role of heritable genetic variation in the pharmacokinetics and pharmacodynamics of anticancer drugs. Expert Opin Pharmacother. 2007;8:11971210.Google Scholar
5. Arranz, MJ. de Leon, J. Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research. Mol Psychiatry. 2007;12:707747.Google Scholar
6. Malhotra, AK, Murphy, GM, Kennedy, JL. Pharmacogenetics of psychotropic drug response. Am J Psychiatry. 2004;161:780796.Google Scholar
7. Hu, XZ, Rush, AJ, Charney, D, et al. Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Arch Gen Psychiatry. 2007;64:783792 Google Scholar
8. Licamele, L, Volpi, S, Heaton, C, et al. Pharmacogenomic study of iloperidone treatment in patients with schizophrenia identifies markers associated with efficacy. Poster presented at: the Annual Meeting of the American Society of Human Genetics. October 23-27, 2007; San Diego, Calif.Google Scholar