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Neuroimaging and the Neuroanatomy of Posttraumatic Stress Disorder

Published online by Cambridge University Press:  07 November 2014

Scott L. Rauch ,
Lisa M. Shin ,
Paul J. Whalen  and
Roger K. Pitman
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Abstract

Contemporary neuroimaging methods have been used to gather initial data regarding the neural substrates of posttraumatic stress disorder (PTSD). Morphometric magnetic resonance imaging (MRI) studies have reliably shown reduced hippocampal volume in subjects with PTSD vs control cohorts. Functional imaging studies have implicated a network of brain regions in PTSD, comprising the amygdala, hippocampus, and anterior paralimbic territories (including anterior cingulate cortex), as well as Broca's area and visual cortex. Extant relevant neuroimaging data are reviewed, and a tentative heuristic neuroanatomical model of PTSD is provided. In conclusion, emerging strategies for advancement in this field are outlined.

Type
Supplement Monograph
Information
CNS Spectrums , Volume 3 , Issue S2: Posttraumatic Stress Disorder: The Hidden Epidemic of Modern Times , August 1998 , pp. 30 - 41
Copyright
Copyright © Cambridge University Press 1998

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References

REFERENCES

1.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
2.Bremner, JD, Randall, P, Scott, TM, et al.MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry. 1995;152:973–981.Google Scholar
3.Aggleton, JP, ed. The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction. New York: Wiley-Liss; 1992.Google Scholar
4.Squire, LR. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev. 1992;99:195–231.Google Scholar
5.Kim, JJ, Fanselow, MS. Modality specific retrograde amnesia of fear. Science. 1992;256:675–677.Google Scholar
6.Phillips, RG, LeDoux, JE. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci. 1992;106:274–285.Google Scholar
7.McNish, KA, Gewirtz, JC, Davis, M. Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-potentiated startle. J Neurosci. 1997;17:9353–9360.Google Scholar
8.Mesulam, M-M. Patterns in behavioral neuroanatomy: association areas, the limbic system, and hemispheric specialization. In: Mesulam, M-M, ed. Principles of Behavioral Neurology. Philadelphia, PA: F.A. Davis Co; 1985:1–70.Google Scholar
9.Devinsky, O. Contributions of anterior cingulate cortex to behavior. Brain. 1995;118:279–306.Google Scholar
10.Vogt, BA, Finch, DM, Olson, CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex. 1992;2:435–443.Google Scholar
11.Myslobodsky, MS, Glicksohn, J, Singer, J, et al.Changes of brain anatomy in patients with posttraumatic stress disorder: a pilot magnetic resonance imaging study. Psychiatry Res. 1995;58:259–264.Google Scholar
12.Canive, J, Lewine, JD, Orrison, WW, et al.MRI reveals gross structural abnormalities in PTSD. In: Yehuda, R, McFarlane, AC, eds. Psychobiology of Posttraumatic Stress Disorder. New York: New York Academy of Sciences; 1997:512–515.Google Scholar
13.Gurvits, TV, Shenton, ME, Hokama, H, et al.Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry. 1996;40:1091–1099.Google Scholar
14.Bremner, JD, Randall, P, Vermetten, E, et al.Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: a preliminary report. Biol Psychiatry. 1997;41:23–32.Google Scholar
15.Stein, MB, Koverola, C, Hanna, C, et al.Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med. 1997;27:951–960.Google Scholar
16.Dager, SR, Steen, RG. Applications of magnetic resonance spectroscopy to the investigation of neuropsychiatric disorders. Neuropsychopharmacology. 1992;6:249–266.Google Scholar
17.Schuff, N, Marmar, CR, Weiss, DS, et al.Reduced hippocampal volume and N-acetyl aspartate in posttraumatic stress disorder. In: Yehuda, R, McFarlane, AC, eds. Psychobwlogy of Posttraumatic Stress Disorder. New York: New York Academy of Sciences; 1997:516–520.Google Scholar
18.Magarinos, AM, McEwen, BS, Flugge, G, et al.Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci. 1996;16:3534–3540.Google Scholar
19.Sapolsky, RM, Uno, H, Rebert, CS, et al.Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci. 1990;10:2897–2902.Google Scholar
20.Yehuda, R. Neuroendocrinology of trauma and posttraumatic stress disorder. In: Yehuda, R, ed. Psychological Trauma. Washington, DC: American Psychiatric Press; 1998:97–132.Google Scholar
21.Rauch, SL, van der Kolk, BA, Fisler, RE, et al.A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry. 1996;53:380–387.Google Scholar
22.Rauch, SL, Jenike, MA, Alpert, NM, et al.Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry. 1994;51:62–70.Google Scholar
23.Rauch, SL, Savage, CR, Alpert, NM, et al.A positron emission tomographic study of simple phobic symptom provocation. Arch Gen Psychiatry. 1995;52:20–28.Google Scholar
24.Reiman, EM, Raichle, ME, Robins, E, et al.Neuroanatomical correlates of a lactate-induced anxiety attack. Arch Gen Psychiatry. 1989;46:493–500.Google Scholar
25.Fredrikson, M, Wik, G, Annas, P, et al.Functional neuroanatomy of visually elicited simple phobic fear: additional data and theoretical analysis. Psychophyswlogy. 1995;32:43–48.Google Scholar
26.Fredrikson, M, Wik, G, Greitz, T, et al.Regional cerebral blood flow during experimental fear. Psychophysiology. 1993;30:126–130.Google Scholar
27.Fischer, H, Wik, G, Fredrikson, M. Functional neuroanatomy of robbery re-experience: affective memories studied with PET. NeuroReport. 1996;7:2081–2086.Google Scholar
28.Shin, LM, McNally, RJ, Kosslyn, SM, et al.A positron emission tomographic study of symptom provocation in PTSD. In: Yehuda, R, McFarlane, AC, eds. Psychobiology of Posttraumatic Stress Disorder. New York: New York Academy of Sciences; 1997:521–523.Google Scholar
29.Semple, WE, Goyer, P, McCormick, R, et al.Preliminary report: brain blood flow using PET in patients with posttraumatic stress disorder and substance-abuse histories. Biol Psychiatry. 1993;34:115–118.Google Scholar
30.Semple, WE, Goyer, P, McCormick, R, et al.Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories. Psychiatry Res Neuroimaging. 1996;67:17–28.Google Scholar
31.Nordahl, TE, Semple, WE, Gross, M, et al.Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology. 1990;3:261–272.Google Scholar
32.Reiman, EM, Raichle, ME, Robins, E, et al.The application of positron emission tomography to the study of panic disorder. Am J Psychiatry. 1986;143:469–477.Google Scholar
33.Shin, LM, Kosslyn, SM, McNally, RJ, et al.Visual imagery and perception in posttraumatic stress disorder: a positron emission tomographic investigation. Arch Gen Psychiatry. 1997;54:233–241.Google Scholar
34.Southwick, SM, Krystal, JH, Morgan, A, et al.Abnormal noradrenergic function in posttraumatic stress disorder. Arch Gen Psychiatry. 1993;50:266–274.Google Scholar
35.Bremner, JD, Innis, RB, Ng, CK, et al.Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry. 1997;54:246–254.Google Scholar
36.Woods, SW, Koster, K, Krystal, JK, et al.Yohimbine alters regional cerebral blood flow in panic disorder. Lancet. 1988;2:678.Google Scholar
37.Benkelfat, C, Bradwejn, J, Meyer, E, et al.Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Am J Psychiatry. 1995;152:1180–1184.Google Scholar
38.Ketter, TA, Andreason, PJ, George, MS, et al.Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry. 1996;53:59–69.Google Scholar
39.Breiter, HC, Etcoff, NL, Whalen, PJ, et al.Response and habituation of the human amygdala during visual processing of facial expression. Neuron. 1996;17:875–887.Google Scholar
40.Cahill, L, Haier, RJ, Fallon, J, et al.Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proc Natl Acad Sci USA. 1996;93:8016–8021.Google Scholar
41.Irwin, W, Davidson, RJ, Lowe, MJ, et al.Human amyg-dala activation detected with echo-planar functional magnetic resonance imaging. NeuroReport. 1996;7:1765–1769.Google Scholar
42.Morris, JS, Frith, CD, Perrett, DI, et al.A differential response in the human amygdala to fearful and happy facial expressions. Nature. 1996;383:812–815.Google Scholar
43.Morris, JS, Friston, KJ, Dolan, RJ. Neural responses to salient visual stimuli. Proc R Soc Lond B Biol Sci. 1997;264:769–775.Google Scholar
44.Whalen, PJ, Rauch, SL, Etcoff, NL, et al.Masked presentations of emotional facial expressions modulate amyg-dala activity without explicit knowledge. J Neurosci. 1998;18:411–418.Google Scholar
45.Whalen, PJ, Bush, G, McNally, R, et al.The digital emotional stroop activates anterior cingulate cortex: an fMRI study. Neuroimage. 1997;5:S121. Abstract.Google Scholar
46.Schacter, DL, Alpert, NM, Savage, CR, et al.Conscious recollection and the human hippocampal formation: evidence from positron emission tomography. Proc Natl Acad Sci USA. 1996;93:321–325.Google Scholar
47.Stern, CE, Corkin, S, Gonzalez, RG, et al.The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci USA. 1996;93:8660–8665.Google Scholar